813416-46-5
Chemical Structure
PKCδ Peptide Substrate
- CAS No.: 813416-46-5
- Formula:C109H191N35O29S
- Molecular Weight:2487.96
IUPAC Name: 1-bromo-3,8-dichloronaphthalene
SMILES: O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](C(C)C)C(NCC(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N
Biological Activity: PKCδ Peptide Substrate is a highly selective peptide substrate targeting PKCδ. PKCδ Peptide Substrate can only be efficiently catalyzed for phosphorylation modification by PKCδ, and Thr431 is the sole phosphorylation site. PKCδ Peptide Substrate binds to the catalytic pocket of PKC in a competitive manner, but exhibits no PKC agonistic or inhibitory activity. PKCδ Peptide Substrate is a dedicated biochemical probe for the quantitative detection of PKCδ in vitro, and can be used for studies on PKCδ-related pathways[1][2][3].
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PKCδ Peptide Substrate | PKCδ Peptide Substrate is a highly selective peptide substrate targeting PKCδ. PKCδ Peptide Substrate can only be efficiently catalyzed for phosphorylation modification by PKCδ, and Thr431 is the sole phosphorylation site. PKCδ Peptide Substrate binds to the catalytic pocket of PKC in a competitive manner, but exhibits no PKC agonistic or inhibitory activity. PKCδ Peptide Substrate is a dedicated biochemical probe for the quantitative detection of PKCδ in vitro, and can be used for studies on PKCδ-related pathways. | |||||||||||||||||||||
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- [1]. Kang JH. Protein Kinase C (PKC) Isozymes and Cancer. New Journal of Science. 2014;2014(1):231418.
- [2]. Nishikawa K, Toker A, Johannes FJ, et al.. Determination of the specific substrate sequence motifs of protein kinase C isozymes. The Journal of biological chemistry. 1997 Jan 10;272(2):952-60. [Content Brief]
- [3]. Kielbassa K, et al. Protein Kinase Cδ-specific Phosphorylation of the Elongation Factor eEF-1α and an eEF-1α Peptide at Threonine 431. The Journal of Biological Chemistry. 1995;270(11):6156-6162.
Keywords
