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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
PROTAC BLIMP-1 degrader-1
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "PROTAC BLIMP-1 degrader-1" in MCE Product Catalog:
Cat. No.: HY-180177
Target:
Research Areas:
PROTAC BLIMP-1 degrader-1 is an orally active BLIMP-1 PROTAC degrader with an EC50 of 13.1 nM. PROTAC BLIMP-1 degrader-1 recruits the neprilysin (CRBN) E3 ligase to mediate ubiquitination and subsequent degradation of BLIMP-1α via the 26S proteasome, without affecting the BLIMP-1β isoform. PROTAC BLIMP-1 degrader-1 inhibits cancer cell proliferation and tumor growth. It can be used in research related to multiple myeloma .
Cat. No.: HY-180178
Research Areas:
BLIMP-1 ligand-1 is a BLIMP-1 ligand. BLIMP-1 ligand-1 can be used for the synthesis of PROTAC BLIMP-1 degrader-1 (HY-180177) .
Cat. No.: HY-180179
Research Areas:
BLIMP-1 Ligand-Linker Conjugate 1 is a conjugate of BLIMP-1 Ligand-1 (HY-180178) and Linker (HY-180180). BLIMP-1 ligand-Linker Conjugate 1 can be coupled with CRBN ligand-881 (HY-W442918) to form PROTAC BLIMP-1 degrader-1 (HY-180177) .
Cat. No.: HY-180180
Target:
Research Areas:
trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid is a PROTAC linker. trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid can be used to synthesize PROTAC BLIMP-1 degrader-1 (HY-180177) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
