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Pentapeptide

" in MedChemExpress (MCE) Product Catalog:

66

Inhibitors & Agonists

65

Peptides

13

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P0288
    [Leu5]-Enkephalin
    2 Publications Verification

    Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin

    		 Opioid Receptor Endogenous Metabolite Neurological Disease
    [Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.
    [Leu5]-Enkephalin
  • HY-P0045
    Palmitoyl pentapeptide 4

    Matrixyl; Palmitoyl Pentapeptide 3; Matrixyl (Palmitoyl Pentapeptide)

    		 Collagen Others
    Palmitoyl pentapeptide 4 (Matrixyl; Palmitoyl pentapeptide 3; Matrixyl (Palmitoyl Pentapeptide) is a bioactive peptide with anti-ageing effect and has been reported used as a cosmetic ingredient [1]
    Palmitoyl pentapeptide 4
  • HY-33046
    N-Boc-dolaproine

    (2R,3R)-BOC-dolaproine

    		 Microtubule/Tubulin Mitosis Cancer
    N-Boc-dolaproine ((2R,3R)-BOC-dolaproine) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    N-Boc-dolaproine
  • HY-19884B
    Relamorelin TFA
    1 Publications Verification

    RM-131 TFA; BIM-28131 TFA

    		 GHSR Metabolic Disease
    Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for GHS-1a receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .
    Relamorelin TFA
  • HY-138053
    Ristocetin A sulfate

    Ristomycin III

    		 Antibiotic Cardiovascular Disease Infection
    Ristocetin A sulfate (Ristomycin III) is a glycopeptide antibiotic that binds to von Willebrand factor (VWF) and bacterial cell wall components. Ristocetin A sulfate interferes with the biosynthesis of bacterial peptidoglycan by inhibiting transpeptidation. As an inducer of platelet adhesion and aggregation, Ristocetin A sulfate drives conformational changes by binding to the A1 domain of VWF, thereby activating downstream signaling pathways and promoting cytoskeletal rearrangement. Ristocetin A sulfate not only enhances platelet adhesion and spreading on immobilized VWF, but also induces the formation of asymmetric dimers with anticooperativity between platelets and plasma VWF. Ristocetin A sulfate is widely used in studies related to thromboembolic diseases and bacterial infections .
    Ristocetin A sulfate
  • HY-P0099
    Pentapeptide-3

    		nAChR Others
    Pentapeptide-3 is a pentapeptide fragment of neurotoxin waglerin-1, it can be extracted from the venom of Temple Viper. Pentapeptide-3 is a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), it can blocks nerves at the post-synaptic membrane. Pentapeptide-3 has anti-aging effects and it can be used together with other cosmetic peptides .
    Pentapeptide-3
  • HY-107024
    Osteogenic Growth Peptide (10-14)

    OGP(10-14); Historphin

    		 Src Others
    Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor .
    Osteogenic Growth Peptide (10-14)
  • HY-P0295
    Gly-Arg-Gly-Asp-Ser

    GRGDS

    		 Integrin Others
    Gly-Arg-Gly-Asp-Ser (GRGDS) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ～5 and ～6.5 μM
    Gly-Arg-Gly-Asp-Ser
  • HY-105077A
    Nemifitide diTFA

    INN 00835 diTFA

    		 5-HT Receptor Neurological Disease
    Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action . Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF) . Nemifitide diTFA can cross the blood-brain barrier .
    Nemifitide diTFA
  • HY-P0275
    Proctolin
    1 Publications Verification

    		 Endogenous Metabolite Neurological Disease
    Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator.
    Proctolin
  • HY-P5840
    Cyclo(RGDyC)

    		Biochemical Assay Reagents Cancer
    Cyclo(RGDyC) is a cyclic pentapeptide with anti-angiogenic abilities. Cyclo(RGDyC) can be combined with liposome delivery systems for research on ocular neovascular diseases and cancer .
    Cyclo(RGDyC)
  • HY-P4047
    Cyclo(RGDfK(Mal))

    		Drug Derivative Others
    Cyclo(RGDfK(Mal)) is a pentapeptide. Cyclo(RGDfK(Mal)) improves the attachment and infiltration of human pluripotent stem cells. Cyclo(RGDfK(Mal)) can be used for 3D stem cell culture and expansion .
    Cyclo(RGDfK(Mal))
  • HY-P0103A
    Myristoyl pentapeptide-17 acetate

    		LPL Receptor Metabolic Disease
    Myristoyl pentapeptide-17 acetate can stimulate eyelash growth by stimulating keratin production. Myristoyl pentapeptide-17 acetate promotes the delivery of key ingredients in the serum, such as the growth factors and lysophosphatidic acid .
    Myristoyl pentapeptide-17 acetate
  • HY-P0103
    Myristoyl pentapeptide-17

    		LPL Receptor Metabolic Disease
    Myristoyl pentapeptide-17 can stimulate eyelash growth by stimulating keratin production. Myristoyl pentapeptide-17 promotes the delivery of key ingredients in the serum, such as the growth factors and lysophosphatidic acid .
    Myristoyl pentapeptide-17
  • HY-P5239
    Myristoyl pentapeptide-4

    		Collagen Others
    Myristoyl pentapeptide-4 is a bioactive peptide with promotion of hair growth effect and has been reported used as a cosmetic ingredient .
    Myristoyl pentapeptide-4
  • HY-P10473A
    CPN-351 TFA

    		Neuromedin U Receptor (NMUR) Inflammation/Immunology
    CPN-351 TFA (compound 9a), a pentapeptide, is a selective antagonist of human NMUR1 with a pA2 of 7.35. The antagonistic effect of CPN-351 TFA on human NMUR1 is 10 times higher than that on NMUR2. CPN-351 TFA can be used in the study of inflammation . X
    CPN-351 TFA
  • HY-P5272
    Histatin-3 TFA

    		Bacterial Inflammation/Immunology
    Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM .
    Histatin-3 TFA
  • HY-166114
    Heptaprenyl-MPDA

    Heptaprenyl phosphate

    		 Biochemical Assay Reagents Infection
    Heptaprenyl-MPDA (Heptaprenyl phosphate) is a short-chain homolog of undecaprenyl phosphate, is an endogenous substrate of Phospho-MurNAc-pentapeptide translocase (MraY). Heptaprenyl-MPDA can be used for bacterial infections research .
    Heptaprenyl-MPDA
  • HY-148663
    Mitogenic Pentapeptide

    Tripalmitoyl Pentapeptide

    		 MAPKAPK2 (MK2) Inflammation/Immunology
    Mitogenic Pentapeptide (Tripalmitoyl pentapeptide) is an effective activator of B lymphocyte mitogen and polyclonal. Mitogen Pentapeptide is a synthetic N-terminal analog of E. coli outer membrane lipoproteins. Mitogenic Pentapeptide can be used for the study of immune adjuvants .
    Mitogenic Pentapeptide
  • HY-166114A
    (Z)-Heptaprenyl-MPDA diammonium

    (Z)-Heptaprenyl phosphate diammonium

    		 Bacterial Infection
    (Z)-Heptaprenyl-MPDA ((Z)-Heptaprenyl phosphate) diammonium is the (Z)-isomer of Heptaprenyl-MPDA (HY-166114). Heptaprenyl-MPDA (Heptaprenyl phosphate) is a short-chain homolog of undecaprenyl phosphate, is an endogenous substrate of Phospho-MurNAc-pentapeptide translocase (MraY). Heptaprenyl-MPDA can be used for bacterial infections research .
    (Z)-Heptaprenyl-MPDA diammonium
  • HY-P10053
    sPLA2-IIA Inhibitor

    		Phospholipase Metabolic Disease
    sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .
    sPLA2-IIA Inhibitor
  • HY-P2643
    Angiotensin I/II (4-8)

    		Endogenous Metabolite Cardiovascular Disease
    Angiotensin I/II (4-8), a major metabolite of Angiotensin II, is a C-terminal 4-8 pentapeptide .
    Angiotensin I/II (4-8)
  • HY-P3102
    GLP-1(32-36)amide

    		GCGR Metabolic Disease
    GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice .
    GLP-1(32-36)amide
  • HY-P1067
    Enterostatin(human,mouse,rat)

    		Endogenous Metabolite Metabolic Disease
    Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake.
    Enterostatin(human,mouse,rat)
  • HY-P11417
    Epidermal mitosis inhibiting pentapeptide

    		DNA/RNA Synthesis Cancer
    Epidermal mitosis inhibiting pentapeptide is a five-peptide that acts as a physiological inhibitor of epidermal cell proliferation. This pentapeptide can significantly reduce the DNA synthesis rate and mitotic rate of epidermal keratinocytes. Epidermal mitosis inhibiting pentapeptide moderately enhances the occurrence of skin tumors in skin cancer models, but also shows a higher tendency to promote the regression of already formed tumors. Epidermal mitosis inhibiting pentapeptide can be hydrolyzed by angiotensin-converting enzyme (ACE). Epidermal mitosis inhibiting pentapeptide can be used in cancer process research .
    Epidermal mitosis inhibiting pentapeptide
  • HY-P3773
    p60c-src substrate II

    		Src Cancer
    p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase pp60c-src .
    p60c-src substrate II
  • HY-42912A
    N-Boc-dolaproine-OH dicyclohexylamine

    		Microtubule/Tubulin Mitosis Cancer
    N-Boc-dolaproine-OH dicyclohexylamine is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    N-Boc-dolaproine-OH dicyclohexylamine
  • HY-33046A
    N-Boc-dolaproine dicyclohexylamine

    (2R,3R)-BOC-dolaproine dicyclohexylamine

    		 Microtubule/Tubulin Mitosis Cancer
    N-Boc-dolaproine dicyclohexylamine is an amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity. And contains dicyclohexylamine .
    N-Boc-dolaproine dicyclohexylamine
  • HY-N8395
    Tunicamycin V
    2 Publications Verification

    Tunicamycin A

    		 Bacterial Infection
    Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC50 of 0.35?μM. Tunicamycin V has antibacterial activties .
    Tunicamycin V
  • HY-78932C
    (2S,3R)-Dap-NE hydrochloride

    		Microtubule/Tubulin Mitosis Cancer
    (2S,3R)-Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    (2S,3R)-Dap-NE hydrochloride
  • HY-P10473
    CPN-351

    		Neuromedin U Receptor (NMUR) Inflammation/Immunology
    CPN-351 (compound 9a), a pentapeptide, is a selective antagonist of human NMUR1 with a pA2 of 7.35. The antagonistic effect of CPN-351 on human NMUR1 is 10 times higher than that on NMUR2. CPN-351 can be used in the study of inflammation .
    CPN-351
  • HY-19884
    Relamorelin

    RM-131; BIM-28131

    		 GHSR Metabolic Disease
    Relamorelin (RM-131), a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for GHS-1a receptor. Relamorelin is centrally penetrant. Relamorelin increases growth hormone levels and accelerates gastric emptying. Relamorelin has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .
    Relamorelin
  • HY-P2569
    Malformin A1

    		Apoptosis Cancer
    Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9 .
    Malformin A1
  • HY-113770
    Lysyl threonine

    Lys-Thr

    		 Drug Intermediate Cancer
    Lysyl threonine (Lys-Thr) is a dipeptide. Lysyl threonine can be used to synthesize the pentapeptide Gly-Thr-Gly-Lys-Thr. Gly-Thr-Gly-Lys-Thr confers cell sensitivity to anticancer agents by inhibiting the binding of CAGE to GSK3β and reducing the expression of CyclinD1 .
    Lysyl threonine
  • HY-19884A
    Relamorelin acetate

    RM-131 acetate; BIM-28131 acetate

    		 GHSR Metabolic Disease
    Relamorelin (RM-131) acetate, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for GHS-1a receptor. Relamorelin acetate is centrally penetrant. Relamorelin acetate increases growth hormone levels and accelerates gastric emptying. Relamorelin acetate has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .
    Relamorelin acetate
  • HY-P1060
    LPYFD-NH2

    		Amyloid-β Neurological Disease
    LPYFD-NH2, a pentapeptide, exerts some inhibitory effect on the aggregation of Aβ(1-42). LPYFD-NH2 can be used for the research of Alzheimer’s disease .
    LPYFD-NH2
  • HY-P1060A
    LPYFD-NH2 TFA

    		Amyloid-β Neurological Disease
    LPYFD-NH2 TFA, a pentapeptide, exerts some inhibitory effect on the aggregation of Aβ(1-42). LPYFD-NH2 TFA can be used for the research of Alzheimer’s disease .
    LPYFD-NH2 TFA
  • HY-120794
    SC-67655

    		TNF Receptor Inflammation/Immunology
    SC 67655 is a potent and stable pentapeptide MHC class II haplotype DR4 (DR4 Dw4 or DRB 1"0401) ligand with an IC50 of 50 nM. SC 67655 can be used for the study of autoimmune diseases .
    SC-67655
  • HY-P3771
    p60c-src substrate II, phosphorylated

    		Src Others
    p60c-src substrate II，phosphorylated is a pentapeptide. p60c-src substrate II，phosphorylated is a p60c-src substrate II phosphorylated polypeptide. Protein phosphorylation is an important post-translationmodification of protein that is indispensible in biological regulations .
    p60c-src substrate II, phosphorylated
  • HY-P3102A
    GLP-1(32-36)amide TFA

    		GCGR Metabolic Disease
    GLP-1(32-36)amide TFA, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide TFA could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice .
    GLP-1(32-36)amide TFA
  • HY-N14452
    Plactin A

    		Others Others
    Plactin A is a cyclic pentapeptide physiologically active substance and promotes the dissolution of fibrinolytic proteins .
    Plactin A
  • HY-N14455
    Plactin D

    		Others Others
    Plactin D is a cyclic pentapeptide physiologically active substance and promotes the dissolution of fibrinolytic proteins .
    Plactin D
  • HY-43304
    N-Boc-dolaproine-methyl

    		Microtubule/Tubulin Mitosis Cancer
    N-Boc-dolaproine-methyl is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    N-Boc-dolaproine-methyl
  • HY-P1067A
    Enterostatin(human,mouse,rat) TFA

    		Endogenous Metabolite Metabolic Disease
    Enterostatin (human,mouse,rat) TFA is a pentapeptide mainly formed in the intestine by the cleavage of secreted pancreatic procolipase. Enterostatin  selectively reduces fat intake, bodyweight, and body fat in vivo .
    Enterostatin(human,mouse,rat) TFA
  • HY-42912
    N-Boc-dolaproine-OH ((+)-phenylethylamine)

    		Microtubule/Tubulin Mitosis Cancer
    N-Boc-dolaproine-OH ((+)-phenylethylamine) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    N-Boc-dolaproine-OH ((+)-phenylethylamine)
  • HY-49053
    N-Boc-dolaproine-amide-Me-Phe

    		Microtubule/Tubulin Mitosis Cancer
    N-Boc-dolaproine-amide-Me-Phe is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    N-Boc-dolaproine-amide-Me-Phe
  • HY-P0288A
    [Leu5]-Enkephalin TFA

    		Opioid Receptor Endogenous Metabolite Neurological Disease
    [Leu5]-Enkephalin TFA is a pentapeptide with morphine like properties. [Leu5]-Enkephalin TFA is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.
    [Leu5]-Enkephalin TFA
  • HY-146426
    MraY-IN-2

    		Bacterial Infection
    MraY-IN-2 (compound 6) is a potent MurNAc-pentapeptide translocase (MraY) inhibitor with an IC50 value of 4.5 μM. MraY-IN-2 can be used for researching anti-bacteria .
    MraY-IN-2
  • HY-78932D
    (2R,3R)-Dap-NE hydrochloride

    		Drug Derivative Mitosis Cancer
    (2R,3R)-Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    (2R,3R)-Dap-NE hydrochloride
  • HY-W104862
    4-Amino-D-phenylalanine

    4-NH2-d-Phe

    		 CXCR Inflammation/Immunology
    4-Amino-D-phenylalanine ([D-Phe(4-NH2)), a cyclic pentapeptide, inhibits CXCL12 binding to CXCR4 in FC131, with an IC50 of 0.1 μM .
    4-Amino-D-phenylalanine

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