2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Nemifitide diTFA

Nemifitide diTFA  (Synonyms: INN 00835 diTFA)

Cat. No.: HY-105077A Purity: 98.01%
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Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF). Nemifitide diTFA can cross the blood-brain barrier.

For research use only. We do not sell to patients.

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Nemifitide diTFA Chemical Structure

Nemifitide diTFA Chemical Structure

CAS No. : 204992-09-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 457 In-stock
Solution
10 mM * 1 mL in Water USD 457 In-stock
Solid
5 mg USD 250 In-stock
10 mg USD 450 In-stock
50 mg USD 1650 In-stock
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Based on 1 publication(s) in Google Scholar

Nemifitide diTFA Related Antibodies

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Description

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action[1]. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF)[2]. Nemifitide diTFA can cross the blood-brain barrier[3].

In Vitro

Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nemifitide diTFA Related Antibodies
In Vivo

Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect[2].
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Flinders Sensitive Line (FSL) rat weighing 280-320 g[2]
Dosage: 0.3 mg/kg
Administration: IP; daily; for 14 days
Result: Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect.
Molecular Weight

922.80

Formula

C37H45F7N10O10
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Fluoro-Phe}-{Hyp}-Arg-Gly-Trp-NH2
Sequence Shortening

{Fluoro-Phe}-{Hyp}-RGW-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (270.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0837 mL 5.4183 mL 10.8366 mL
5 mM 0.2167 mL 1.0837 mL 2.1673 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0837 mL 5.4183 mL 10.8366 mL 27.0915 mL
5 mM 0.2167 mL 1.0837 mL 2.1673 mL 5.4183 mL
10 mM 0.1084 mL 0.5418 mL 1.0837 mL 2.7091 mL
15 mM 0.0722 mL 0.3612 mL 0.7224 mL 1.8061 mL
20 mM 0.0542 mL 0.2709 mL 0.5418 mL 1.3546 mL
25 mM 0.0433 mL 0.2167 mL 0.4335 mL 1.0837 mL
30 mM 0.0361 mL 0.1806 mL 0.3612 mL 0.9030 mL
40 mM 0.0271 mL 0.1355 mL 0.2709 mL 0.6773 mL
50 mM 0.0217 mL 0.1084 mL 0.2167 mL 0.5418 mL
60 mM 0.0181 mL 0.0903 mL 0.1806 mL 0.4515 mL
80 mM 0.0135 mL 0.0677 mL 0.1355 mL 0.3386 mL
100 mM 0.0108 mL 0.0542 mL 0.1084 mL 0.2709 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nemifitide diTFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemifitide diTFA204992-09-6INN 00835 diTFA5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorPentapeptideantidepressantrapidonsetpeptidemelanocyte-inhibitingfactorMIFblood-brainbarrierInhibitorinhibitorinhibit

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