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Nemifitide diTFA (Synonyms: INN 00835 diTFA)

Cat. No.: HY-105077A Purity: 99.13%
Handling Instructions

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF). Nemifitide diTFA can cross the blood-brain barrier.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Nemifitide diTFA Chemical Structure

Nemifitide diTFA Chemical Structure

CAS No. : 204992-09-6

Size Price Stock Quantity
10 mM * 1 mL in Water USD 457 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action[1]. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF)[2]. Nemifitide diTFA can cross the blood-brain barrier[3].

In Vitro

Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin[3].

In Vivo

Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect[2].
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses[2].

Animal Model: Male Flinders Sensitive Line (FSL) rat weighing 280-320 g[2]
Dosage: 0.3 mg/kg
Administration: IP; daily; for 14 days
Result: Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect.
Molecular Weight

922.80

Formula

C₃₇H₄₅F₇N₁₀O₁₀

CAS No.

204992-09-6

Sequence

{Fluoro-Phe}-{Hyp}-Arg-Gly-Trp-NH2

Sequence Shortening

{Fluoro-Phe}-{Hyp}-RGW-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (270.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0837 mL 5.4183 mL 10.8366 mL
5 mM 0.2167 mL 1.0837 mL 2.1673 mL
10 mM 0.1084 mL 0.5418 mL 1.0837 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Nemifitide diTFAINN 00835 diTFAOthersPentapeptideantidepressantrapidonsetpeptidemelanocyte-inhibitingfactorMIFblood-brainbarrierInhibitorinhibitorinhibit

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Nemifitide diTFA
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