Nemifitide diTFA
Based on 1 Customer Validation
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF). Nemifitide diTFA can cross the blood-brain barrier.
For research use only. We do not sell to patients.
- Purity: 98.24%
- CAS No.: 204992-09-6
- Formula: C37H45F7N10O10
- Molecular Weight:922.80
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Flinders Sensitive Line (FSL) rat weighing 280-320 g[2]
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Dosage:0.3 mg/kg
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Administration:IP; daily; for 14 days
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Result:Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect.
Chemical Information
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CAS No. 204992-09-6
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Appearance Solid
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Molecular Weight 922.80
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Formula C37H45F7N10O10
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Color White to off-white
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Synonyms
INN 00835 diTFA
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Sequence
{Fluoro-Phe}-{Hyp}-Arg-Gly-Trp-NH2
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Sequence Shortening
{Fluoro-Phe}-{Hyp}-RGW-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 250 mg/mL (270.91 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Kelly JP, et al. The effect of treatment with a new antidepressant, INN 00835, on platelet serotonin uptake in depressed patients. J Affect Disord. 1999 Oct;55(2-3):231-5. [Content Brief]
[2]. Overstreet DH, et al. Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression. Psychopharmacology (Berl). 2004 Sep;175(3):303-9. [Content Brief]
[3]. Montgomery SA, et al. Efficacy and safety of 30 mg/d and 45 mg/d nemifitide compared to placebo in major depressivedisorder. Int J Neuropsychopharmacol. 2006 Oct;9(5):517-28. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0837 mL | 5.4183 mL | 10.8366 mL | 27.0915 mL |
| 5 mM | 0.2167 mL | 1.0837 mL | 2.1673 mL | 5.4183 mL | |
| 10 mM | 0.1084 mL | 0.5418 mL | 1.0837 mL | 2.7091 mL | |
| 15 mM | 0.0722 mL | 0.3612 mL | 0.7224 mL | 1.8061 mL | |
| 20 mM | 0.0542 mL | 0.2709 mL | 0.5418 mL | 1.3546 mL | |
| 25 mM | 0.0433 mL | 0.2167 mL | 0.4335 mL | 1.0837 mL | |
| 30 mM | 0.0361 mL | 0.1806 mL | 0.3612 mL | 0.9030 mL | |
| 40 mM | 0.0271 mL | 0.1355 mL | 0.2709 mL | 0.6773 mL | |
| 50 mM | 0.0217 mL | 0.1084 mL | 0.2167 mL | 0.5418 mL | |
| 60 mM | 0.0181 mL | 0.0903 mL | 0.1806 mL | 0.4515 mL | |
| 80 mM | 0.0135 mL | 0.0677 mL | 0.1355 mL | 0.3386 mL | |
| 100 mM | 0.0108 mL | 0.0542 mL | 0.1084 mL | 0.2709 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Nemifitide diTFA Related Classifications
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