204992-09-6
Chemical Structure
Nemifitide diTFA
Synonym(s): INN 00835 diTFA
- CAS No.: 204992-09-6
- Formula:C37H45F7N10O10
- Molecular Weight:922.80
IUPAC Name: (2S,4R)-N-((S)-1-((2-(((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-2-oxoethyl)amino)-5-guanidino-1-oxopentan-2-yl)-1-((S)-2-amino-3-(4-fluorophenyl)propanoyl)-4-hydroxypyrrolidine-2-carboxamide bis(2,2,2-trifluoroacetate)
InChIKey: QXCFOJXOLMOPRK-QOXNQHIRSA-N
SMILES: FC(C=C1)=CC=C1C[C@H](N)C(N2[C@@H](C[C@@H](O)C2)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N)=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Biological Activity: Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action[1]. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF)[2]. Nemifitide diTFA can cross the blood-brain barrier[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nemifitide diTFA | 98.24% | Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF). Nemifitide diTFA can cross the blood-brain barrier. | ||||||||||||||||||||
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Nemifitide diTFA (Standard) | ≥98% | Nemifitide diTFA (Standard) is the analytical standard of Nemifitide diTFA (HY-105077A). This product is intended for research and analytical applications. Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF). Nemifitide diTFA can cross the blood-brain barrier. | ||||||||||||||||||||
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- [1]. Kelly JP, et al. The effect of treatment with a new antidepressant, INN 00835, on platelet serotonin uptake in depressed patients. J Affect Disord. 1999 Oct;55(2-3):231-5. [Content Brief]
- [2]. Overstreet DH, et al. Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression. Psychopharmacology (Berl). 2004 Sep;175(3):303-9. [Content Brief]
- [3]. Montgomery SA, et al. Efficacy and safety of 30 mg/d and 45 mg/d nemifitide compared to placebo in major depressivedisorder. Int J Neuropsychopharmacol. 2006 Oct;9(5):517-28. [Content Brief]
