204992-09-6
Chemical Structure
Nemifitide diTFA
Synonym(s): INN 00835 diTFA
- CAS No.: 204992-09-6
- Formula:C37H45F7N10O10
- Molecular Weight:922.80
IUPAC Name: (2S,4R)-N-((S)-1-((2-(((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-2-oxoethyl)amino)-5-guanidino-1-oxopentan-2-yl)-1-((S)-2-amino-3-(4-fluorophenyl)propanoyl)-4-hydroxypyrrolidine-2-carboxamide bis(2,2,2-trifluoroacetate)
InChIKey: QXCFOJXOLMOPRK-QOXNQHIRSA-N
SMILES: FC(C=C1)=CC=C1C[C@H](N)C(N2[C@@H](C[C@@H](O)C2)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N)=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Biological Activity: Nemifitide diTFA (INN 00835 diTFA) is a 5-HT2A receptor ligand that crosses the blood-brain barrier. Nemifitide diTFA is used in research related to major depressive disorder[1][2][3].
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Nemifitide diTFA | 98.24% | Nemifitide diTFA (INN 00835 diTFA) is a 5-HT2A receptor ligand that crosses the blood-brain barrier. Nemifitide diTFA is used in research related to major depressive disorder. | ||||||||||||||||||||
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Nemifitide diTFA (Standard) | ≥98% | Nemifitide diTFA (Standard) (INN 00835 diTFA (Standard)) is the analytical standard of Nemifitide diTFA (HY-105077A). This product is intended for research and analytical applications. Nemifitide diTFA (INN 00835 diTFA) is a 5-HT2A receptor ligand that crosses the blood-brain barrier. Nemifitide diTFA is used in research related to major depressive disorder. | ||||||||||||||||||||
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References
- [1]. Montgomery SA, et al. Efficacy and safety of 30 mg/d and 45 mg/d nemifitide compared to placebo in major depressive disorder. The international journal of neuropsychopharmacology. 2006 Oct;9(5):517-28. [Content Brief]
- [2]. Overstreet DH, et al. Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression. Psychopharmacology. 2004 Sep;175(3):303-9. [Content Brief]
- [3]. Feighner JP, et al. Clinical pharmacokinetic studies with INN 00835 (nemifitide), a novel pentapeptide antidepressant. Biopharmaceutics & drug disposition. 2002 Jan;23(1):33-9.
