Proctolin
Based on 1 publication(s) in Google Scholar
Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator.
For research use only. We do not sell to patients.
- Purity: 98.56%
- CAS No.: 57966-42-4
- Formula: C30H48N8O8
- Molecular Weight:648.75
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Proctolin
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
Proctolin can increase the frequency of action potentials, increase the amplitude of muscle contraction, and initiate activity in quiescent systems[1]. In the arthropods, Proctolin acts as a neuromodulator and possibly as a neurohormone. It does not appear to function as a conventional neurotransmitter[2]. Proctolin is a pentapeptide with the mature peptide of RYLPT, and it is the first insect neuropeptide to be sequenced and chemically characterized. The first identification of a Proctolin precursor gene is CG7105 in D. melanogaster. Although a previous study showed that Proctolin is absent in B. mori, this pentapeptide is recently identified in a proteomic analysis of B. mori wings. However, the Bombyx Proctolin gene does not produce a mature peptide because cleavage sites are not present at the N-terminal and C-terminal of the RYLPT sequence, and a similar gene is observed in C. suppressalis. Therefore, a true Proctolin has been considered to be not observed in B. mori and C. suppressalis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 57966-42-4
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Appearance Solid
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Molecular Weight 648.75
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Formula C30H48N8O8
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Color White to off-white
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Sequence
Arg-Tyr-Leu-Pro-Thr
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Sequence Shortening
RYLPT
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Structure Classification
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Initial Source
Periplaneta americana
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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iScience
2022 Jul 2;25(8):104697. PMID: 35880044
Solvent & Solubility
H2O : 100 mg/mL (154.14 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: ≥ 100 mg/mL (154.14 mM); Clear solution
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. McGrath LL, et al. De novo transcriptome assembly for the lobster Homarus americanus and characterization of differential gene expression across nervous system tissues. BMC Genomics. 2016 Jan 16;17:63. [Content Brief]
[2]. Orchard I, et al. Proctolin: a review with emphasis on insects. J Neurobiol. 1989 Jul;20(5):470-96. [Content Brief]
[3]. Xu G, et al. Identification and expression profiles of neuropeptides and their G protein-coupled receptors in the rice stem borer Chilo suppressalis. Sci Rep. 2016 Jun 29;6:28976. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.5414 mL | 7.7071 mL | 15.4143 mL | 38.5356 mL |
| 5 mM | 0.3083 mL | 1.5414 mL | 3.0829 mL | 7.7071 mL | |
| 10 mM | 0.1541 mL | 0.7707 mL | 1.5414 mL | 3.8536 mL | |
| 15 mM | 0.1028 mL | 0.5138 mL | 1.0276 mL | 2.5690 mL | |
| 20 mM | 0.0771 mL | 0.3854 mL | 0.7707 mL | 1.9268 mL | |
| 25 mM | 0.0617 mL | 0.3083 mL | 0.6166 mL | 1.5414 mL | |
| 30 mM | 0.0514 mL | 0.2569 mL | 0.5138 mL | 1.2845 mL | |
| 40 mM | 0.0385 mL | 0.1927 mL | 0.3854 mL | 0.9634 mL | |
| 50 mM | 0.0308 mL | 0.1541 mL | 0.3083 mL | 0.7707 mL | |
| 60 mM | 0.0257 mL | 0.1285 mL | 0.2569 mL | 0.6423 mL | |
| 80 mM | 0.0193 mL | 0.0963 mL | 0.1927 mL | 0.4817 mL | |
| 100 mM | 0.0154 mL | 0.0771 mL | 0.1541 mL | 0.3854 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Proctolin Related Classifications
HY-P0275 Related Classifications
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