560130-42-9
Chemical Structure
Telavancin hydrochloride
Synonym(s): TD-6424 hydrochloride
- CAS No.: 560130-42-9
- Formula:C80H107Cl3N11O27P
- Molecular Weight:1792.10
InChIKey: GSSIWSIRBWAZHG-ACOPVEIWSA-N
SMILES: ClC1=CC([C@H]([C@H](C(N[C@H](C(N[C@@]2([H])C(N[C@]3([H])C4=CC=C(O)C(C5=C(O)C(CNCP(O)(O)=O)=C(O)C=C5[C@H](NC([C@](NC3=O)([H])[C@@H](C6=CC=C(O7)C(Cl)=C6)O)=O)C(O)=O)=C4)=O)=O)CC(N)=O)=O)NC([C@H](NC)CC(C)C)=O)O)=CC=C1OC8=C(C7=CC2=C8)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)O)O[C@H]%10C[C@@](C)([C@@H]([C@@H](O%10)C)O)NCCNCCCCCCCCCC.Cl
Biological Activity: Telavancin hydrochloride (TD-6424 hydrochloride) is a bactericidal agent that exhibits inhibitory activity against Staphylococcus aureus. Telavancin hydrochloride inhibits bacterial cell wall synthesis by binding to the lipid-linked N-acetylglucosamine-N-muramyl pentapeptide (with a D-Ala-D-Ala terminus), a peptidoglycan precursor, and blocks the transglycosylation and transpeptidation steps. Telavancin hydrochloride disrupts bacterial membrane barrier function, induces dissipation of bacterial membrane potential, and causes leakage of cytoplasmic ATP and potassium ions, with its activity restricted exclusively to bacterial membranes. Telavancin hydrochloride can be used in research on bacterial infections, central venous catheter-related bloodstream infections, and Gram-positive bacterial pneumonia[1][2][3].
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Telavancin hydrochloride | 99.88% | Telavancin hydrochloride (TD-6424 hydrochloride) is a bactericidal agent that exhibits inhibitory activity against Staphylococcus aureus. Telavancin hydrochloride inhibits bacterial cell wall synthesis by binding to the lipid-linked N-acetylglucosamine-N-muramyl pentapeptide (with a D-Ala-D-Ala terminus), a peptidoglycan precursor, and blocks the transglycosylation and transpeptidation steps. Telavancin hydrochloride disrupts bacterial membrane barrier function, induces dissipation of bacterial membrane potential, and causes leakage of cytoplasmic ATP and potassium ions, with its activity restricted exclusively to bacterial membranes. Telavancin hydrochloride can be used in research on bacterial infections, central venous catheter-related bloodstream infections, and Gram-positive bacterial pneumonia. | ||||||||||||||||||||
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References
- [1]. Lyseng-Williamson KA, et al. Telavancin. Drugs. 2009;69(18):2607-20. [Content Brief]
- [2]. Bookstaver PB, et al. Stability and compatibility of antimicrobial lock solutions. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2013 Dec 15;70(24):2185-98. [Content Brief]
- [3]. Saravolatz LD, et al. Telavancin: a novel lipoglycopeptide. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2009 Dec 15;49(12):1908-14. [Content Brief]
