3 Results for "

Pomalidomide-piperazine

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Pomalidomide-piperazine" in MCE Product Catalog:

Cat. No.: HY-148834
CAS No.: 2154342-57-9
Target:  

Ligands for E3 Ligase

Research Areas:  

Others

Pomalidomide-piperazine is an active compound that can be used to synthesis the E3 ligand for PROTAC .
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Cat. No.: HY-148834B
CAS No.: 2230956-83-7
Research Areas:  

Cancer

Pomalidomide-piperazine hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
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Cat. No.: HY-169232
Target:  

PROTACs PD-1/PD-L1

Research Areas:  

Cancer

PCC16 chloride is a dual PROTAC degrader targeting DHHC3 and PD-L1, with a DC50 of 0.103 μM for PD-L1 degradation. PCC16 chloride induces DHHC3 degradation via the ubiquitin-proteasome pathway by recruiting the CRBN E3 ubiquitin ligase (E3 ubiquitin ligase). By targeting DHHC3-which is essential for PD-L1 palmitoylation and membrane stability-PCC16 chloride reduces PD-L1 levels, decreases PD-L1 membrane retention time, and impairs its immunosuppressive function. PCC16 chloride enhances anti-tumor immunity by disrupting PD-L1-mediated immunosuppression. PCC16 chloride can be used in the research of immune checkpoint blockade-resistant cancers .
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