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Propargyl-PEG4-hydrazide

" in MedChemExpress (MCE) Product Catalog:

標的別:	ADC Linker (1) Biochemical Assay Reagents (2) Fluorescent Dye (1) GnRH Receptor (1) Integrin (2) Liposome (1) Radionuclide-Drug Conjugates (RDCs) (1) SARS-CoV (1) VEGFR (1)
研究分野別:	Cancer (5) Infection (1)
クリックケミストリー:	ADC Synthesis (1) Azide (1) Alkynes (1)

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製品番号	製品名	Target	研究分野	構造式

HY-P10303

*Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)]* Cyclo[RGDfK(Azide)]	Biochemical Assay Reagents	Others
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .

HY-133427

*Propargyl-PEG4-hydrazide*	ADC Linker	Cancer
Propargyl-PEG4-hydrazide is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-hydrazide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P11026

DOTA-TMVP1446 DOTA-PEG4-TMVP1446	VEGFR	Cancer
DOTA-TMVP1446 is a VEGFR-3 targeting peptide. DOTA-TMVP1446 labeled with ⁶⁸Ga accurately detectes the status of lymph node metastasis, even in micrometastatic tumors, in the B16-F10 tumor mice model. DOTA-TMVP1446 can be used as a radiotracer for cancer-metastatic sentinel lymph nodes (m-SLN) imaging .

HY-P10590

Talogreptide mesaroxetan	Fluorescent Dye	Cancer
Talogreptide mesaroxetan is a diagnostic imaging agent, with antineoplastic effect .

HY-P2115

Ramorelix	GnRH Receptor	Cancer
Ramorelix is a luteinizing-hormone-releasing hormone (LHRH) antagonist. Ramorelix can inhibit tumor progression in vivo. Ramorelix can be studied in anti-cancer research .

HY-P10906

Talovirtide	Biochemical Assay Reagents	Others
Talovirtide is a peptide containing L-valyl .

HY-P11455

Lipopeptide CPE4	Liposome	Others
Lipopeptide CPE4 is a PEG-modified peptide E4 [(EIAALEK) ⁴]. Lipopeptide CPE4 is capable of coiled-coil formation when attached to liposomes. Lipopeptide CPE4 triggers membrane fusion between liposomes and living cells with concomitant efficient cytosolic delivery of a variety of compounds such as fluorescent dyes Propidium Iodide (PI) (HY-D0815) and TO-PRO-3 iodide (HY-117070), and Doxorubicin (DOX) (HY-15142A). Lipopeptide CPE4 can be used for drug delivery research .

HY-P10872

P315V3	SARS-CoV	Infection
P315V3 is an pan inhibitor for coronavirus, that inhibits SARS-CoV-2 prototypePT, Delta, BA.1 and BA.4 strain with IC₅₀s of 10.9, 8.9, 8.6, and 2.7 nM. P315V3 exhibits cytotoxicity in Vero cell with CC₅₀ of 4.3 μM. P315V3 exhibits anti-infectious efficacy in mouse models .

HY-P11773

3P-RGD2	Radionuclide-Drug Conjugates (RDCs) Integrin	Others
3P-RGD2 is a dimeric cyclic RGD (Arg-Gly-Asp) peptide. When radiolabeled with ^99mTc, 3P-RGD2 serves as a selective radiotracer for integrin α_vβ₃. When radiolabeled with ^99mTc, 3P-RGD2 enables single-photon emission computed tomography imaging of integrin α_vβ₃ .

HY-P11774

HYNIC-3P-RGD2	Integrin	Cancer
HYNIC-3P-RGD2 is a dimeric cyclic RGD peptide with high binding affinity for integrin α_vβ₃ (IC₅₀ = 33 nM). HYNIC-3P-RGD2 acts as a precursor molecule for radiotracers and is used to detect tumor angiogenesis .

製品番号	製品名	Target	研究分野

HY-P10303

*Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)]* Cyclo[RGDfK(Azide)]	Biochemical Assay Reagents	Others
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .

HY-P11026

DOTA-TMVP1446 DOTA-PEG4-TMVP1446	VEGFR	Cancer
DOTA-TMVP1446 is a VEGFR-3 targeting peptide. DOTA-TMVP1446 labeled with ⁶⁸Ga accurately detectes the status of lymph node metastasis, even in micrometastatic tumors, in the B16-F10 tumor mice model. DOTA-TMVP1446 can be used as a radiotracer for cancer-metastatic sentinel lymph nodes (m-SLN) imaging .

HY-P10590

Talogreptide mesaroxetan	Fluorescent Dye	Cancer
Talogreptide mesaroxetan is a diagnostic imaging agent, with antineoplastic effect .

HY-P2115

Ramorelix	GnRH Receptor	Cancer
Ramorelix is a luteinizing-hormone-releasing hormone (LHRH) antagonist. Ramorelix can inhibit tumor progression in vivo. Ramorelix can be studied in anti-cancer research .

HY-P10906

Talovirtide	Biochemical Assay Reagents	Others
Talovirtide is a peptide containing L-valyl .

HY-P11455

Lipopeptide CPE4	Liposome	Others
Lipopeptide CPE4 is a PEG-modified peptide E4 [(EIAALEK) ⁴]. Lipopeptide CPE4 is capable of coiled-coil formation when attached to liposomes. Lipopeptide CPE4 triggers membrane fusion between liposomes and living cells with concomitant efficient cytosolic delivery of a variety of compounds such as fluorescent dyes Propidium Iodide (PI) (HY-D0815) and TO-PRO-3 iodide (HY-117070), and Doxorubicin (DOX) (HY-15142A). Lipopeptide CPE4 can be used for drug delivery research .

HY-P10872

P315V3	SARS-CoV	Infection
P315V3 is an pan inhibitor for coronavirus, that inhibits SARS-CoV-2 prototypePT, Delta, BA.1 and BA.4 strain with IC₅₀s of 10.9, 8.9, 8.6, and 2.7 nM. P315V3 exhibits cytotoxicity in Vero cell with CC₅₀ of 4.3 μM. P315V3 exhibits anti-infectious efficacy in mouse models .

HY-P11773

3P-RGD2	Radionuclide-Drug Conjugates (RDCs) Integrin	Others
3P-RGD2 is a dimeric cyclic RGD (Arg-Gly-Asp) peptide. When radiolabeled with ^99mTc, 3P-RGD2 serves as a selective radiotracer for integrin α_vβ₃. When radiolabeled with ^99mTc, 3P-RGD2 enables single-photon emission computed tomography imaging of integrin α_vβ₃ .

HY-P11774

HYNIC-3P-RGD2	Integrin	Cancer
HYNIC-3P-RGD2 is a dimeric cyclic RGD peptide with high binding affinity for integrin α_vβ₃ (IC₅₀ = 33 nM). HYNIC-3P-RGD2 acts as a precursor molecule for radiotracers and is used to detect tumor angiogenesis .

製品番号	製品名		Classification

HY-P10303

*Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)]* Cyclo[RGDfK(Azide)]		Azide
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .

HY-133427

*Propargyl-PEG4-hydrazide*		ADC Synthesis Alkynes
Propargyl-PEG4-hydrazide is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-hydrazide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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