2767993-86-0
![Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] Chemical Structure](http://file.medchemexpress.com/product_pic/hy-p10303.gif "Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] Chemical Structure")
Chemical Structure
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)]
Synonym(s): Cyclo[RGDfK(Azide)]
- CAS No.: 2767993-86-0
- Formula:C30H44N12O8
- Molecular Weight:700.75
InChIKey: PMCLQALAMBMZHA-KJJMTIBFSA-N
SMILES: O=C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CCCCNC(CCN=[N+]=[N-])=O)[C@H]1CC2=CC=CC=C2
Biological Activity: Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] (Cyclo[RGDfK(Azide)]) is a derivative of Cyclo (-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys (Azide)] is a click chemistry reagent containing an azide group. Cyclo[Arg-Gly-Asp-D-Phe-Lys (Azide)] enables functionalization of alginate via SPAAC bioconjugation. Alginate hydrogels functionalized with Cyclo[Arg-Gly-Asp-D-Phe-Lys (Azide)] significantly promote cell expansion while maintaining cell pluripotency[1][2].
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Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] | 99.93% | Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] (Cyclo[RGDfK(Azide)]) is a derivative of Cyclo (-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys (Azide)] is a click chemistry reagent containing an azide group. Cyclo[Arg-Gly-Asp-D-Phe-Lys (Azide)] enables functionalization of alginate via SPAAC bioconjugation. Alginate hydrogels functionalized with Cyclo[Arg-Gly-Asp-D-Phe-Lys (Azide)] significantly promote cell expansion while maintaining cell pluripotency. | ||||||||||||||||||||
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Similarity Score 0.90
HY-P11339c-RGD-SH -
Similarity Score 0.87
HY-P5287cRGDfK-thioacetyl ester -
Similarity Score 0.86
HY-P0023Cyclo(-RGDfK) -
Similarity Score 0.84
HY-P0023ACyclo(-RGDfK) TFA -
Similarity Score 0.83
HY-P5021Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) -
Similarity Score 0.83
HY-P6438Alkyne-cRGD -
Similarity Score 0.83
HY-P4047Cyclo(RGDfK(Mal)) -
Similarity Score 0.83
HY-P5025Cyclo(Arg-Gly-Asp-D-Tyr-ε-azido-Nle) -
Similarity Score 0.80
HY-P0031Cyclo(RADfK) -
Explore the MedChemAI to find more analogs
References
- [1]. Hashemi M, et al. Xeno-Free Peptide-Functionalized Hydrogels Support hiPSC Encapsulation and In Situ Differentiation into Structurally Mature Cardiomyocytes. bioRxiv [Preprint]. 2026 Jul 10:2026.07.08.737331.
- [2]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789. [Content Brief]
