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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
SETDB1 Tudor domain
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "SETDB1 Tudor domain" in MCE Product Catalog:
6
6 Cited Publications
Cat. No.: HY-141539A
Purity: 99.77%
Target:
Research Areas:
SETDB1-TTD-IN-1 TFA is a potent, selective and endogenous binder competitive ligand of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD) that binds to TTD, with a Kd of 88 nM. SETDB1-TTD-IN-1 TFA increases SETDB1 methyltransferase activity. SETDB1-TTD-IN-1 TFA can be used for the research of biological functions and disease associations of SETDB1-TTD .
Cat. No.: HY-173156
Target:
Research Areas:
UNC10013 is an inhibitor targeting the triple Tudor domain (3TD) of SETDB1. UNC10013 covalently binds to Cys385 of SETDB1 3TD, acts as a negative allosteric modulator of the methyltransferase domain of SETDB1, reduces the level of Akt methylation mediated by SETDB1, and blocks Tyr308 phosphorylation of Akt. UNC10013 is applicable to cancer-related research .
Cat. No.: HY-168992
Target:
Research Areas:
UNC6535 is a covalent ligand targeting the SETDB1 triple Tudor domain (3TD) with negative allosteric modulator properties, with an IC50 of 3.4 μM and a Kd of 4.2 μM. UNC6535 inhibits the methyltransferase activity of recombinant SETDB1 protein lacking the 3TD domain. UNC6535 reversibly binds to the aromatic cages of both TD2 and TD3 subdomains of SETDB1 3TD simultaneously, displacing the endogenous H3K9Me2K14Ac histone tail ligand. UNC6535 can be used in research on cancer and neurodegenerative diseases .
Cat. No.: HY-168992A
Target:
Research Areas:
UNC6535 TFA is a covalent ligand targeting the triple Tudor domain (3TD) of SETDB1. UNC6535 TFA reversibly binds to the aromatic cages of both TD2 and TD3 within SETDB1 3TD simultaneously, weakly inhibits the methyltransferase activity of SETDB1, and displaces the H3K9Me2K14Ac peptide from SETDB1 3TD .
Cat. No.: HY-P703071
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SETDB1; ERG-Associated Protein With SET domain; SET domain Bifurcated Histone Lysine Methyltransferase 1; Histone H3-K9 Methyltransferase 4; SET domain Bifurcated 1; Lysine N-Methyltransferase 1E; KMT1E; Tudor domain Containing 21; ESET; Histone-Lysine N-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703604
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SETDB1; ERG-Associated Protein With SET domain; SET domain Bifurcated Histone Lysine Methyltransferase 1; Histone H3-K9 Methyltransferase 4; SET domain Bifurcated 1; Lysine N-Methyltransferase 1E; KMT1E; Tudor domain Containing 21; ESET; Histone-Lysine N-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-181914
Target:
Research Areas:
UNC7242 is an antagonist that binds to the Tudor domains of PHF1 and PHF19, with a Kd of 1.13 μM for PHF1 and 0.64 μM for PHF19. UNC7242 fails to displace full-length PHF1 or PHF19 from H3K36me3 nucleosomes or chromatin. UNC7242 can be used in studies related to multiple myeloma, endometrial stromal sarcoma, and ossifying fibromyxoid tumor .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
