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SK-5527

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-179641

    PROTACs Aurora Kinase Cancer
    SK5527 is a selective AURKA PROTAC degrader degrading AURKA with DC50 = 2 nM. SK5527 bind to NanoLuc-AURKA with an IC50 of 20 nM. SK5527 effectively reduces MYCN levels in MYCN-amplified neuroblastoma cells and limited by MDR1-mediated efflux. SK5527 efficiently reduced AURKA levels in vivo. SK5527 can be used for neuroblasto2ma research .
    SK5527
  • HY-179644

    E3 Ligase Ligand-Linker Conjugates Cancer
    E3 Ligase Ligand-linker Conjugate 222 is a E3 ligase ligand-linker conjugate that incorporates a CRBN (Thalidomide) ligand and a linker. E3 Ligase Ligand-linker Conjugate 222 can be connected to the target protein ligand to form a SK5527 PROTAC (HY-179641) .
    E3 Ligase Ligand-linker Conjugate 222

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