3131860-12-0
Chemical Structure
SK5527
- CAS No.: 3131860-12-0
- Formula:C42H49ClF3N11O3
- Molecular Weight:848.36
InChIKey: HIODCMZUTOISEE-UHFFFAOYSA-N
SMILES: FC1=CC=C(N=C1CC2(CCN(CC2)CC3=C(C(Cl)=CC=C3)F)C(N4CCC(F)(CN5CCN(C6=CC=C(C=N6)N7C(NC(CC7)=O)=O)CC5)CC4)=O)NC8=NNC(C)=C8
Biological Activity: SK5527 is a selective AURKA PROTAC degrader degrading AURKA with DC50 = 2 nM. SK5527 bind to NanoLuc-AURKA with an IC50 of 20 nM. SK5527 effectively reduces MYCN levels in MYCN-amplified neuroblastoma cells and limited by MDR1-mediated efflux. SK5527 efficiently reduced AURKA levels in vivo. SK5527 can be used for neuroblasto2ma research[1].
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SK5527 | SK5527 is a selective AURKA PROTAC degrader degrading AURKA with DC50 = 2 nM. SK5527 bind to NanoLuc-AURKA with an IC50 of 20 nM. SK5527 effectively reduces MYCN levels in MYCN-amplified neuroblastoma cells and limited by MDR1-mediated efflux. SK5527 efficiently reduced AURKA levels in vivo. SK5527 can be used for neuroblasto2ma research. | |||||||||||||||||||||
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Keywords
