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Saposhnikovia divaricata

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (1) Drug Derivative (1) Interleukin Related (1) TNF Receptor (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (2) Neurological Disease (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Hamaudol 2 Publications Verification	COX	Inflammation/Immunology
Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC₅₀ values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects .

visamminol-3'-O-glucoside	Others	Cancer
Visamminol-3'-O-glucoside (Compound 4) is a chromone glycoside, which is initially isolated from Saposhnikovia divaricata. Visamminol-3'-O-glucoside exhibits weak cytotoxicity against cancer cells PC-3, SK-OV-3 and H460, with IC₅₀s of 93.91, >100 and >100 μM, respectively .

6''-Apiosyl sec-O-glucosylhamaudol	Drug Derivative	Cancer
6''-Apiosyl sec-O-glucosylhamaudol (Compound 1) is a chromone glycoside found in the roots of Saposhnikovia divaricata. 6''-Apiosyl sec-O-glucosylhamaudol is promising for research of cancers .

Divaricatol	Interleukin Related TNF Receptor	Neurological Disease Inflammation/Immunology
Divaricatol is an orally ative chromone natural product and an active component in Saposhnikovia divaricata. Divaricatol reduces the release of pro-inflammatory cytokines and restores immune homeostasis by stably binding to 5KIR (a target of the TNF/IL-17 pathway). Divaricatol exerts analgesic effects in mouse models. Divaricatol can be used in the research of pain, diarrhea-predominant irritable bowel syndrome (IBS-D) and qi deficiency syndrome .

Hamaudol 2 Publications Verification	Monophenols Classification of Application Fields Ophryosporus axilliflorus Hieron. Ketones, Aldehydes, Acids Phenols Plants Umbelliferae Disease Research Fields Inflammation/Immunology Source Classification	COX
Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC₅₀ values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects .

visamminol-3'-O-glucoside	Ophryosporus axilliflorus Hieron. Umbelliferae Plants Saccharides Monosaccharides Source Classification	Others
Visamminol-3'-O-glucoside (Compound 4) is a chromone glycoside, which is initially isolated from Saposhnikovia divaricata. Visamminol-3'-O-glucoside exhibits weak cytotoxicity against cancer cells PC-3, SK-OV-3 and H460, with IC₅₀s of 93.91, >100 and >100 μM, respectively .

6''-Apiosyl sec-O-glucosylhamaudol	Structural Classification Flavonoids Ophryosporus axilliflorus Hieron. Umbelliferae Plants Other Flavonoids Source Classification	Drug Derivative
6''-Apiosyl sec-O-glucosylhamaudol (Compound 1) is a chromone glycoside found in the roots of Saposhnikovia divaricata. 6''-Apiosyl sec-O-glucosylhamaudol is promising for research of cancers .

Divaricatol	Structural Classification Monophenols Xeranthemum annuum L. Phenols Umbelliferae Plants Source Classification	Interleukin Related TNF Receptor
Divaricatol is an orally ative chromone natural product and an active component in Saposhnikovia divaricata. Divaricatol reduces the release of pro-inflammatory cytokines and restores immune homeostasis by stably binding to 5KIR (a target of the TNF/IL-17 pathway). Divaricatol exerts analgesic effects in mouse models. Divaricatol can be used in the research of pain, diarrhea-predominant irritable bowel syndrome (IBS-D) and qi deficiency syndrome .

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