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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
Sulfonamide derivative
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "Sulfonamide derivative" in MCE Product Catalog:
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E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) .
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Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 μM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water .
Cat. No.: HY-69077
CAS No.: 875781-17-2
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Anti-inflammatory agent 51 (compound 11d) is an amide/sulfonamide derivative with anti-inflammatory activities. Anti-inflammatory agent 51 inhibits NF-κB activation, has the potential for acute lung injury and ulcerative colitis research .
Cat. No.: HY-W004121
CAS No.: 1623-93-4
Cat. No.: HY-177331
CAS No.: 1259029-47-4
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BTT-3034, a sulfonamide derivative, is an α2β1 integrin inhibitor. BTT-3034 inhibits cell adhesion to rat tail collagen I with an EC50 of 160 nM and a corresponding Emaxof 86%. BTT-3034 inhibits collagen binding by an α2 variant carrying the conformationally activating E318W mutation .
Antimicrobial agent-14, a benzyl thiophene sulfonamide derivative is an antimicrobial agent, with a MIC of 200 μM against Campylobacter coli ATCC33559. Antimicrobial agent-14 can be used for the research of bacterial foodborne gastroenteritis .
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TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257 .
Cat. No.: HY-B0553S
CAS No.: 1795142-30-1
Synonyms: L584601-d6
Cat. No.: HY-B0661CS
CAS No.: 1189923-88-3
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hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea .
Cat. No.: HY-177324
CAS No.: 2163817-03-4
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Antibacterial agent 290 (Compound YY), a sulfonamide derivative, is an antibacterial agent. Antibacterial agent 290 has antiproliferative activity against a variety of tumor cells. Antibacterial agent 290 significantly activates the E3 Ligase Parkin auto-ubiquitinvlation with an EC50 of 0.4 μM. Antibacterial agent 290 can used for synthesis of building blocks for various supramolecular structures such as metal-organic skeletons and coordination polymers. Antibacterial agent 290 can be used for cancers, neurology disorders and infections research .
Cat. No.: HY-CE01569
Synonyms: Phenylalanine-N-Sulfonamide-coenzyme A
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Phenylalanine-N-sulfonamide-CoA (Phenylalanine-N-sulfonamide-coenzyme A) is a coenzyme A derivative .
Cat. No.: HY-W031230
CAS No.: 127-73-1
Synonyms: Acetylsulfamerazine; Sulfamelazine
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N4-Acetylsulfamerazine is a sulfonamides derivative .
Cat. No.: HY-123438
CAS No.: 206551-25-9
WAY-151693, sulfonamide derivative of a hydroxamic acid, acts as a potent inhibitor of MMP13 in virtual screening .
Cat. No.: HY-168179
CAS No.: 2301159-96-4
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RORγt inverse agonist 32 (compound b14) is orally active. RORγt inverse agonist 32 can be used in inflammation research .
Cat. No.: HY-163718
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Ferroptosis-IN-9 (compound 23b) is a ferroptosis inhibitor with an IC50 value of >30uM for hERG inhibition. Ferroptosis-IN-9 is a ROS scavenger. Ferroptosis-IN-9 can be used in neurodegenerative disease research .
Cat. No.: HY-W698694
CAS No.: 1189896-03-4
Synonyms: Acetylsulfamerazine-d4; Sulfamelazine-d4
Cat. No.: HY-163116
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Anti-inflammatory agent 67 (compound 7a) is a dual inhibitor of carbonic anhydrase and COX-2, a sulfonamide derivative of Polmacoxib (HY-16726), and has anti-inflammatory properties and analgesic activity. Anti-inflammatory agent 67 has IC50s of 10.4 μM and 50 nM for COX-1 and COX-2, respectively. The Ki of anti-inflammatory agent 67 binding to different isoforms of carbonic anhydrase are 48.3 nM (CA I), 42.2 nM (CA II), 52.3 nM (CA IX), and 13.3 nM (CA XII) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
