1795142-30-1
Chemical Structure
Methazolamide-d6
Synonym(s): L584601-d6
- CAS 番号: 1795142-30-1
- Formula:C5H2D6N4O3S2
- Molecular Weight:242.31
IUPAC Name: (Z)-N-(3-(methyl-d3)-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide-d3
InChIKey: FLOSMHQXBMRNHR-OXIQCEOHSA-N
SMILES: [2H]C([2H])([2H])C(/N=C1SC(S(N)(=O)=O)=NN\1C([2H])([2H])[2H])=O
Biological Activity: Methazolamide-d6 is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders[1][2].
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Methazolamide-d6 | Methazolamide-d6 is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders. | |||||||||||||||||||||
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Methazolamide (Standard) | ≥98% | Methazolamide (Standard) is the analytical standard of Methazolamide. This product is intended for research and analytical applications. Methazolamide (L584601) is a BBB-penetrable and orally active carbonic anhydrase inhibitor, with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide can reduce intraocular pressure and has a neuroprotective effect, being able to inhibit neuronal apoptosis. Methazolamide can be used in the research of ophthalmic diseases such as glaucoma and cerebrovascular diseases such as subarachnoid hemorrhage. | ||||||||||||||||||||
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Methazolamide | 99.41% | Methazolamide (L584601) is a BBB-penetrable and orally active carbonic anhydrase inhibitor, with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide can reduce intraocular pressure and has a neuroprotective effect, being able to inhibit neuronal apoptosis. Methazolamide can be used in the research of ophthalmic diseases such as glaucoma and cerebrovascular diseases such as subarachnoid hemorrhage. | ||||||||||||||||||||
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Similarity Score 0.75
HY-B0782RAcetazolamide (Standard) -
Similarity Score 0.72
HY-184759Methyl acetazolamide -
Similarity Score 0.69
HY-W074975AAcetazolamide impurity 4 -
Similarity Score 0.69
HY-W074975CL 5343 -
Similarity Score 0.68
HY-W460096Acetazolamide impurity 5 -
Similarity Score 0.68
HY-B0782SAcetazolamide-d3 -
Similarity Score 0.68
HY-B0782S2Acetazolamide-15N,d3 -
Similarity Score 0.61
HY-W566406Aminozolamide -
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Yang F, et al. HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese. Pharmacogenomics J. 2016;16(1):83-87. [Content Brief]
