2 Results for "

TGFβ-IN-5

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "TGFβ-IN-5" in MCE Product Catalog:

1
TGFβ-IN-5
TGFβ-IN-5
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1 Cited Publications
Cat. No.: HY-128437
CAS No.: 259870-32-1
Purity:  98.03%
Target:  

TGF-β Receptor

Research Areas:  

Inflammation/Immunology

TGFβ-IN-5 is a type I transforming growth factor-β receptor (TGF-β R1) kinase inhibitor with an IC50 value of 0.0485 μM. TGFβ-IN-5 reverses the effect of TGF-β-mediated cell activation on the expression of fibrosis-related genes. TGFβ-IN-5 can be used in the research of fibroproliferative diseases .
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Kaempferol 3-O-gentiobioside
Kaempferol 3-O-gentiobioside
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Cat. No.: HY-N1510
CAS No.: 22149-35-5
Category:  

Flavonols Flavonoids Sauropus spatulifolius Beille Metabolic Disease Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields

Target:  

Glycosidase Notch Toll-like Receptor (TLR) NF-κB Mucin Reactive Oxygen Species (ROS) Bacterial TGF-beta/Smad Anaplastic lymphoma kinase (ALK)

Kaempferol 3-O-gentiobioside is an orally active flavonoid, with a Ka value of 57 µM against human NOTCH1 and an IC50 value of 50 μM against α-glucosidase. Kaempferol 3-O-gentiobioside inhibits the NOTCH signaling pathway. It downregulates the expression of TLR4 and NLRP3, and suppresses the activation and nuclear translocation of NF-κB. Kaempferol 3-O-gentiobioside inhibits the expression of MUC5AC, reduces nitrite and ROS levels, and attenuates excessive mucus secretion. It exhibits antibacterial activity, reducing the formation and growth of MRSA biofilms. Kaempferol 3-O-gentiobioside blocks the TGF-β/ALK5/Smad signaling pathway and inhibits epithelial-mesenchymal transition. It suppresses the proliferation, migration, invasion and metastatic growth of tumor cells. Kaempferol 3-O-gentiobioside alleviates airway inflammation and mucus hypersecretion in mice with allergic asthma . It reduces the volume of ovarian cancer xenografts in mice. Kaempferol 3-O-gentiobioside can be used in research related to allergic asthma, diabetes, MRSA infection, breast cancer, gastric cancer and ovarian cancer .
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