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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
TIR signal
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "TIR signal" in MCE Product Catalog:
34
34 Publications Verification
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TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway . TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI) .
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16 Cited Publications
Cat. No.: HY-19744
CAS No.: 2437475-16-4
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T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively .
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10 Cited Publications
Cat. No.: HY-P2565
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7
7 Cited Publications
Synonyms: 2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid
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PEO-IAA is an indole-3-acetic acid (IAA) antagonist. PEO-IAA is an auxin antagonist that binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs).
Cat. No.: HY-P10719
CAS No.: 1421052-89-2
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Cat. No.: HY-113851
CAS No.: 1020201-82-4
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BH-IAA is a potent auxin antagonist that specifically blocks TIR1-mediated auxin signaling .
Cat. No.: HY-175022
CAS No.: 2432992-21-5
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PROTAC IRAK4 degrader-13 (Degrader 1) is a selective IRAK4 PROTAC degrader with DC50s of 0.86 and 1.1 nM for monocytes and lymphocytes in PBMCs, respectively. PROTAC IRAK4 degrader-13 significantly induces TIR signal activation, and inhibits the expression of circulating proinflammatory cytokines in Imiquimod (HY-B0180) induced psoriasis mice model. PROTAC IRAK4 degrader-13 can be used for TLR- and IL-1R-driven driven neutrophilic inflammation diseases like hidradenitis suppurativa (HS) and atopic dermatitis (AD) research . Pink: IRAK4 ligand; Blue: E3 ligase ligand; Black: linker
Cat. No.: HY-P10719A
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Cat. No.: HY-B0868
CAS No.: 25168-26-7
2,4-D isooctyl ester, a synthetic auxin herbicide, is a TIR1 protein transport inhibitor. 2,4-D isooctyl ester interacts with TIR1 to facilitate auxin signal transduction, activating auxin-mediated growth responses. 2,4-D isooctyl ester functions as a pro-herbicide bio-transformed into phytotoxic 2,4-D post-plant absorption, disrupting normal plant growth. 2,4-D isooctyl ester can be used to control broadleaf weeds .
Cat. No.: HY-P10229
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Cat. No.: HY-P10718
CAS No.: 1229954-79-3
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Cat. No.: HY-187762
CAS No.: 868215-90-1
Synonyms: F1800-0169
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AAL1 is a synthetic auxin analog with weak auxin activity, which acts through the auxin receptor TIR1. AAL1 inhibits root and hypocotyl growth of dark-grown Arabidopsis thaliana seedlings, with growth inhibition IC50 values of approximately 20 μM and 50 μM, respectively. AAL1 activates the auxin signaling pathway, promotes DII-VENUS degradation and auxin-responsive gene expression, and its biological effects depend on the auxin influx and efflux transport systems. AAL1 can be used to study weak genetic interactions in the auxin signaling pathway and the regulation of auxin function by amino acids .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
