Search Result

Results for "

Tg

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Acyltransferase (3) Akt (3) AMPK (1) Amyloid-β (5) Antibiotic (4) Apoptosis (14) Autophagy (3) Bacterial (7) Bcr-Abl (1) Beta-lactamase (2) Beta-secretase (2) Biochemical Assay Reagents (31) Btk (1) c-Fms (1) Cathepsin (2) CD19 (1) CD20 (2) CD47 (1) CDK (7) COX (1) CXCR (2) DNA Glycosylase (1) Drug Derivative (4) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (1) DYRK (1) Dystrophin (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (44) Ephrin Receptor (1) ERK (2) FAK (2) Fatty Acid Synthase (FASN) (2) Ferroptosis (4) FGFR (5) FLT3 (6) Fluorescent Dye (6) GABA Receptor (1) GCGR (1) GLP Receptor (1) Glutaminase (19) Glutathione Peroxidase (4) GPR109A (1) HDAC (1) iGluR (2) Integrin (2) Interleukin Related (1) Isotope-Labeled Compounds (23) JAK (12) LDLR (3) Lipase (2) Liposome (1) Lipoxygenase (1) LXR (2) Microtubule/Tubulin (1) MMP (1) Monoamine Oxidase (1) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (2) Parasite (1) PCSK9 (2) PD-1/PD-L1 (1) PDGFR (5) Phosphodiesterase (PDE) (2) PI3K (3) PKA (2) PPAR (4) Prostaglandin Receptor (7) PROTACs (3) Proteasome (1) Proton Pump (1) Reactive Oxygen Species (ROS) (6) Reference Standards (12) RET (2) SARS-CoV (3) Small Interfering RNA (siRNA) (4) Src (8) STAT (1) Tau Protein (2) Thyroid Hormone Receptor (1) TMV (1) Transglutaminase (3) Transmembrane Glycoprotein (2) TSH Receptor (1) VEGFR (6) Virus Protease (2) γ-secretase (1)
By Research Areas:	Cancer (51) Cardiovascular Disease (12) Endocrinology (5) Infection (12) Inflammation/Immunology (25) Metabolic Disease (72) Neurological Disease (14)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (1) siRNAs (4)

250

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10409

Fedratinib Maximum Cited Publications 51 Publications Verification Tg-101348; SAR 302503	JAK Apoptosis	Cancer
Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC₅₀s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces cancer cell apoptosis and has the potential for myeloproliferative disorders research .

HY-P2962

Transglutaminase, Streptoverticillium mobaraense Tg	Biochemical Assay Reagents	Infection Inflammation/Immunology
Transglutaminase, Streptoverticillium mobaraense (TG) is an enzyme that forms cross-links between protein molecules. Transglutaminase, Streptoverticillium mobaraense attaches proteins and peptides to small molecules, polymers, surfaces, DNA and other proteins. Transglutaminase, Streptoverticillium mobaraense is widely used in food applications in the meat, fish, dairy and baking industries .

HY-10410

TG101209 5 Publications Verification	FLT3 JAK RET Autophagy Apoptosis	Cancer
TG101209 is a selective JAK2 inhibitor with IC₅₀ of 6 nM, less potent to Flt3 and RET with IC₅₀ of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations.

HY-10409A

Fedratinib hydrochloride hydrate Maximum Cited Publications 51 Publications Verification Tg-101348 hydrochloride hydrate; SAR 302503 hydrochloride hydrate	JAK Apoptosis	Cancer
Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC₅₀s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib hydrochloride hydrate induces cancer cell apoptosis and has the potential for myeloproliferative disorders research .

HY-10111

TG100-115 2 Publications Verification	PI3K	Cardiovascular Disease Cancer
TG100-115 is a selective PI3Kγ/PI3Kδ inhibitor with IC₅₀s of 83 and 235 nM, respectively.

HY-16978

TG6-10-1 5+ Cited Publications	5-HT Receptor Prostaglandin Receptor	Neurological Disease Endocrinology
TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors .

HY-15338

TG003 5+ Cited Publications	CDK	Cancer
TG003 is a potent inhibitor of Clk1/Sty; inhibits Clk1 and Clk4 with IC₅₀ values of 20 and 15 nM, respectively .

HY-137438

Edralbrutinib Tg-1701	Btk	Cancer
Edralbrutinib (TG-1701) is a highly selective, orally available irreversible BTK inhibitor, with an EC₅₀ of 6.70 nM and a K_d of 3 nM against human BTK. Edralbrutinib inhibits downstream signaling of the B cell receptor, induces dephosphorylation of Ikaros Ser442/445, promotes nuclear exclusion of Ikaros, attenuates Ikaros gene signatures, and exerts anti-tumor activity. Edralbrutinib can be used in research related to B-cell non-Hodgkin lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma .

HY-18971

TG4-155 1 Publications Verification	Prostaglandin Receptor	Neurological Disease Inflammation/Immunology Endocrinology Cancer
TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a K_i of 9.9 nM . TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1 . TG4-155 has an EP2 Schild K_B of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor .

HY-111023

Nemonoxacin malate 1 Publications Verification Tg-873870 malate	Antibiotic Bacterial	Infection
Nemonoxacin (TG-873870) malate is a nonfluorinated quinolone antibiotic. Nemonoxacin malate has broad-spectrum activity against Gram-positive, Gram-negative and atypical pathogens. Nemonoxacin malate can inhibit drug-resistant Streptococcus pneumoniae and Methicillin-resistant Staphylococcus aureus. Nemonoxacin malate can be used for the research of community-acquired pneumonia .

HY-19867A

Burixafor hydrobromide Tg-0054 hydrobromide	CXCR	Cardiovascular Disease Cancer
Burixafor (TG-0054) hydrobromide is a potent CXCR4 antagonist with a pIC₅₀ of 7.4. Burixafor hydrobromide inhibits the binding of CXCL12 to CXCR4, antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2, and blocks the downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction. Burixafor hydrobromide mobilizes CD34 ⁺ hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood. Burixafor hydrobromide can be used for research on autologous hematopoietic stem cell transplantation (ASCT) .

HY-15163

Zotiraciclib 2 Publications Verification Tg02; SB1317	JAK CDK FLT3	Cancer
Zotiraciclib (TG02; SB1317) is an orally active JAK2/FLT3/CDK2 inhibitor with IC₅₀ values of 13 nM, 73 nM and 56 nM , respectively. Zotiraciclib inhibits cancer cell proliferation, tumor growth and the activity of CYP2D6. Zotiraciclib exhibits high plasma protein binding rate, Caco-2 permeability and tissue distribution capacity, as well as metabolic stability in human and canine liver microsomes. Zotiraciclib achieves tumor growth inhibition in nude mouse models of colon cancer and lymphoma xenografts. Zotiraciclib can be used for research related to colon cancer, B-cell lymphoma, advanced leukemia, acute leukemia and multiple myeloma .

HY-117678

TG-2-IN-1 2 Publications Verification	Glutaminase	Others
TG-2-IN-1 (Compound D003) is a transglutaminase-2 (TGM-2) inhibitor. TG-2-IN-1 can be used for the research of myopia .

HY-14956

Nemonoxacin 1 Publications Verification Tg-873870	Antibiotic Bacterial	Infection Inflammation/Immunology
Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .

HY-P99538

Ublituximab LFB-R603; Tg-1101; TgTX-1101	CD20	Cancer
Ublituximab (LFB-R603; TG-1101; TGTX-1101) is a next-generation, type 1 chimeric monoclonal antibody targeting a unique epitope on the CD20 antigen. Ublituximab has anticancer effects .

HY-10185

TG 100572 Hydrochloride 3 Publications Verification	Src VEGFR FGFR PDGFR	Inflammation/Immunology
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC₅₀s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.

HY-P99833

Cosibelimab CK-301; Tg-1501	PD-1/PD-L1	Cancer
Cosibelimab (CK-301) is a high-affinity, fully human PD-L1-blocking monoclonal antibody that binds PD-L1 and blocks its interaction with PD-1. Cosibelimab exhibits antitumor efficacy .

HY-10186

TG 100801 1 Publications Verification	VEGFR FGFR PDGFR Src	Cancer
TG 100801 is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC₅₀s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.

HY-13514

TG 100713 2 Publications Verification	PI3K	Cancer
TG 100713 is an inhibitor of PI3K, with IC₅₀s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively .

HY-W674124

Tripentadecanoin Tg(15:0/15:0/15:0); 1,2,3-Tripentadecanoyl glycerol	Endogenous Metabolite	Metabolic Disease
Tripentadecanoin (TG(15:0/15:0/15:0)) is a triacylglycerol that contains pentadecanoic acid (HY-W004283) at the sn-1, sn-2, and sn-3 positions.

HY-122631

TG693	CDK Dystrophin	Others
TG693 is an orally active inhibitor of CLK1. TG693 regulates the mutated exon 31 of the dystrophin gene in vivo. TG693 is used in Duchenne muscular dystrophy (DMD) research .

HY-164049

TG8-260	Prostaglandin Receptor	Inflammation/Immunology
TG8-260 is a second-generation EP2 antagonist developed to alleviate the pathology of central nervous system and peripheral diseases driven by inflammation. TG8-260 can reduce neuroinflammation and gliosis in the hippocampus of rats after pilocarpine-induced persistent epileptic status. Pharmacokinetic data of TG8-260 showed that its plasma half-life was 2.14 hours and its oral bioavailability was 77.3%. TG8-260 is also a potent inhibitor of CYP450 and shows antagonistic activity in inhibiting EP2 receptor-mediated inflammatory gene expression in BV2-hEP2 microglia, which is suitable for studying anti-inflammatory pathways in animal models of peripheral inflammatory diseases .

HY-122709

TG2 inhibitor VA4	Glutaminase	Cancer
TG2 inhibitor VA4 (compound VA4) is an irreversible Type 2 transglutaminase (TG2) inhibitor. TG2 inhibitor VA4 reacts exclusively at the TG2 transamidase site, inhibits both transamidase and GTP-binding activities .

HY-10184

TG 100572	Src VEGFR PDGFR FGFR	Cancer
TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC₅₀s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.

HY-P990694

Zeripatamig Tg-1801	CD19 CD47	Inflammation/Immunology
Zeripatamig is an anti-CD19/CD47 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-102073

TG53	Glutaminase Integrin FAK Src	Cancer
TG53 is a potent inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. TG53 inhibits formation of a complex with integrin β1 and activation of FAK and c-Src during SKOV3 cell attachment onto FN. TG53 can be used for ovarian cancer research .

HY-172089

TG101209 analog 1	Apoptosis	Cancer
TG101209 analog 1 (Compound 8h) is an inhibitor for BUB1B with an IC₅₀ of 10.36 μM. TG101209 analog 1 exhibits cytotoxicity (IC₅₀ for Caki-1 is 1.347 μM), induce necrosis and apoptosis .

HY-10187

TG 100801 Hydrochloride	VEGFR FGFR PDGFR Src	Cancer
TG 100801 Hydrochloride is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC₅₀s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.

HY-P11348

TG-MMP-Lys	MMP	Cancer
TG-MMP-Lys is an MMP-sensitive crosslinking peptide. TG-MMP-Lys is promising for research of fibrotic diseases (e.g., liver fibrosis) .

HY-158614

1-Palmitoyl-2-12-PAHSA-3-oleoyl-sn-glycerol 16:0-12-PAHSA-18:1-Tg; Tg(16:0/12-PAHSA/18:1)	Endogenous Metabolite	Others
1-Palmitoyl-2-12-PAHSA-3-oleoyl-sn-glycerol (16:0-12-PAHSA-18:1-TG) is a FAHFAs-containing triglyceride that can be synthesized from isotope-labeled FAHFAs, whose decomposition can regulate intracellular FAHFAs levels, and is the major reservoir of FAHFAs in cells and tissues, revealing the activity of a new branch of TG and FAHFAs metabolism.

HY-14956S

Nemonoxacin-d3 Tg-873870-d₃	Bacterial	Inflammation/Immunology
Nemonoxacin-d₃ is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .

HY-N11286

Tridocosahexaenoylglycerol Tg-DHA; Meganol D	Others	Neurological Disease Metabolic Disease Inflammation/Immunology
Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .

HY-10409R

Fedratinib (Standard) Tg-101348 (Standard); SAR 302503 (Standard)	Reference Standards JAK Apoptosis	Cancer
Fedratinib (Standard) is the analytical standard of Fedratinib. This product is intended for research and analytical applications. Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces cancer cell apoptosis and has the potential for myeloproliferative disorders research .

HY-E70436

Human keratinocyte transglutaminase Tg1; Tgase 1	Biochemical Assay Reagents	Others
Human keratinocyte transglutaminase (TG1) is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70439

Human epidermal transglutaminase Tg3; Tgase 3	Biochemical Assay Reagents	Others
Human epidermal transglutaminase (TG3) is a transferase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-W704600

1,3-Distearoyl-2-oleoyl glycerol Tg(18:0/18:1/18:0)	Biochemical Assay Reagents	Others
1,3-Distearoyl-2-oleoyl glycerol (TG(18:0/18:1/18:0)) is a triglyceride that can be isolated from native fats such as such as kokum, shea butter and mango kernel fat. 1,3-Distearoyl-2-oleoyl glycerol is widely used in the chocolate industry as a cocoa butter modifier and an anti-blooming agent .

HY-E70453

Human prostate transglutaminase Prostate Transglutaminase; Tg4; Tgase 4	Biochemical Assay Reagents	Metabolic Disease
Human prostate transglutaminase (TG4; TGase 4) is an enzyme that mediates the transfer of acyl groups from glutamine residues in proteins or peptides to primary amines and belongs to the prostate transglutaminase protein family. Human prostate transglutaminase forms an ε-(γ-glutamyl)lysine bond between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue .

HY-E70454

Human neuronal transglutaminase Neuronal Transglutaminase; Tgy; Tg6	Biochemical Assay Reagents	Others
Human epidermal transglutaminase (Neuronal Transglutaminase) is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70437

Guinea pig liver transglutaminase Tissue-type transglutaminase; Tg2; Tgase 2	Biochemical Assay Reagents	Others
Guinea pig liver transglutaminase (Tissue-type transglutaminase) is an exoenzyme. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-165041

1,3-Dioleoyl-2-stearoyl glycerol 1,3-Olein-2-stearin; Tg(18:1/18:0/18:1)	Others	Others
1,3-Dioleoyl-2-stearoyl glycerol (1,3-Olein-2-stearin) is a compound mentioned in the study of triglyceride composition in bovine milk fat. It has been identified and quantified by various methods, and its proportion and type in bovine milk fat have been determined.

HY-176751

TG-2-IN-5	Glutaminase	Cancer
TG-2-IN-5 (Compound CP4d) is a reversible *TG2* inhibitor with a K_i of 1.0 μM for human TG2. TG-2-IN-5 can be used to study diseases associated with upregulation of TG2-mediated acyl transfer, such as fibrosis and cancer .

HY-18970

TG6-129	Prostaglandin Receptor	Inflammation/Immunology
TG6-129 is a selective antagonist of the EP₂ receptor. TG6-129 reduces the expression of inflammatory factors induced by butaprost in P388D1 macrophages .

HY-158774

TG2-179-1	Apoptosis	Cancer
TG2-179-1 is a potent BAP1 inhibitor. TG2-179-1 inhibits the domain-containing deubiquitinase (DUB) activity of BAP1 by covalently binding to its active site. TG2-179-1 exerts cytotoxic activity, leading to defective replication and increased apoptosis. TG2-179-1 has the potential for colon cancer research .

HY-158763

MPI8 Tg0205221	SARS-CoV Cathepsin Virus Protease	Infection
MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). MPI8 can be used in clinical studies of COVID-19 .

HY-158763A

MPI8 TFA Tg0205221 TFA	SARS-CoV Cathepsin Virus Protease	Infection
MPI8 (TG0205221) TFA is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 TFA exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). MPI8 TFA can be used in clinical studies of COVID-19 .

HY-173547

1-Palmitoyl-2-9-pahsa-3-oleoyl-sn-glycerol Tg(16:0/9-Pahsa/18:1)	Endogenous Metabolite	Metabolic Disease
1-Palmitoyl-2-9-pahsa-3-oleoyl-sn-glycerol is a PAHSA-containing compound. 1-Palmitoyl-2-9-pahsa-3-oleoyl-sn-glycerol can be used in the research of adipose tissue .

HY-111298

TG 41	GABA Receptor	Neurological Disease
TG 41 is positive modulator of GABAA receptor. TG 41 enhances the binding both of GABA and of Flunitrazepam to rat cerebral cortical membranes .

HY-158659

TG11-77 hydrochloride	Prostaglandin Receptor	Neurological Disease Inflammation/Immunology
TG11-77 hydrochloride is a potent, selective, orally active and brain permeant EP2 antagonist, with a K_B of 9.7 nM. TG11-77 hydrochloride inhibits PGE2-induced human EP2 receptor activation. TG11-77 hydrochloride exhibits anti-inflammatory activity. TG11-77 hydrochloride reduces delayed mortality and memory deficit .

HY-171217

TG-100435	Src Bcr-Abl Ephrin Receptor	Cancer
TG-100435 is a multitargeted, orally active protein tyrosine kinase inhibitor, with K_i of 13 to 64 nM for Src, Lyn, Abl, Yes, Lck, and EphB4. TG-100435 plays an important role in cancer research .

HY-160132

TG-2-IN-4	Glutaminase	Inflammation/Immunology
TG-2-IN-4 (compound 8) is a transglutaminase 2 (TG2) inhibitor with an IC₅₀ <0.5 mM. TG-2-IN-4 can be used for the research of inflammatory disorder .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-112540B

Acetoacetic acid sodium	Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Acetoacetic acid sodium is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid sodium induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid sodium can be used to study metabolic diseases .

HY-B0747

Eicosapentaenoic acid ethyl ester EPA ethyl ester; Ethyl eicosapentaenoate; AMR101	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Eicosapentaenoic acid ethyl ester (EPA ethyl ester) is an orally active ω-3 fatty acid agent. Eicosapentaenoic acid ethyl ester could improve the activity of liver β-oxidase in vitro, reduce the level of liver total triglyceride, increase the content of liver triglyceride and phospholipid ω-3 fatty acid, and increase the total ω-3 fatty acid level in rats .

HY-N2118

Bilobetin 2 Publications Verification	Flavonoids Ginkgoaceae Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Biflavones Ginkgo biloba Disease Research Fields Source Classification	PPAR PKA Akt p38 MAPK ERK
Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-112540

Acetoacetic acid 4 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
Acetoacetic acid is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid can be used to study metabolic diseases .

HY-N2078

Yamogenin Neodiosgenin	other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Steroids Source Classification	LXR Reactive Oxygen Species (ROS) Apoptosis Fatty Acid Synthase (FASN)
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC₅₀ of 1421.92 μg/mL. Yamogenin can be studied in research on gastric cancer .

HY-112540A

Acetoacetic acid lithium 4 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Acetoacetic acid lithium is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid lithium induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid lithium can be used to study metabolic diseases .

HY-B1434

7-Aminocephalosporanic acid 2 Publications Verification 7-ACA	Infection Classification of Application Fields Disease Research Fields	Beta-lactamase Bacterial Antibiotic
7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor .

HY-N15875

18:1-18:1-C11 BODIPY 505/515 TG	Structural Classification Lipid	Fluorescent Dye
18:1-18:1-C11 BODIPY 505/515 TG is a fluorescently-labeled triglyceride that can be used as a fluorescent probe (Ex/Em = 495/503 nm).

HY-N0368R

Linalool (Standard) 4 Publications Verification	Cardiovascular Disease Classification of Application Fields Terpenoids Amberboa moschata (L.) DC. Umbelliferae Plants Endogenous metabolite Disease Research Fields Source Classification	Reference Standards iGluR Apoptosis Endogenous Metabolite
Linalool (Standard) is the analytical standard of Linalool. This product is intended for research and analytical applications. Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity .Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome .

HY-N11286

Tridocosahexaenoylglycerol Tg-DHA; Meganol D	Structural Classification Animals Lipid Source Classification	Others
Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .

HY-N15883

18:1-C11 BODIPY 505/515-C11 BODIPY 505/515 TG	Lipid	Fluorescent Dye
18:1-C11 BODIPY 505/515-C11 BODIPY 505/515 TG is a fluorescently-labeled triglyceride that can be used to measure triacylglycerol hydrolases (Ex/Em = 495/503 nm) .

HY-122989

Aristolactam BIII	Alkaloids Other Alkaloids Fissistigma glaucescens Plants Annonaceae Source Classification	DYRK
Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC₅₀= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models .

HY-N12249

7-Deoxy-trans-dihydronarciclasine	Hosta plantaginea (Lam.) Aschers. Alkaloids Quinoline Alkaloids Plants Source Classification Asparagaceae Juss.	Amyloid-β TMV
7-Deoxy-trans-dihydronarciclasine, an alkaloid, is a tobacco mosaic virus (TMV) inhibitor (IC₅₀: 1.80 μM). 7-Deoxy-trans-dihydronarciclasine is an anti-neuroinflammatory agent. 7-Deoxy-trans-dihydronarciclasine decreases the Aβ and APP levels in the cerebral cortex of Tg2576 mice .

HY-N8214

Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside	Cardiovascular Disease Flavonols Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Others
Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside is a bioactive constituent that can be found in the seeds of Lepidium apetalum Willd. Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside exhibits significant triglyceride (TG)-lowering effects in HepG2 cells .

HY-N15859

16:0-LR/18:1/18:1 TG - Lissamine rhodamine	Lipid	Fluorescent Dye
16:0-LR/18:1/18:1 TG-lissamine rhodamine is a fluorescent lipid.

HY-N7907

Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside	Leguminosae Phenols Polyphenols Sphaerophysa salsula (Pall.) DC. Plants	Others
Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside is a natural product that can be obtained from sphaerophysa salsula. Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside inhibits triglyceride (TG) accumulation in 3T3-L1 adipocytes .

HY-N15876

18:1-6:0 DNP-C11 BODIPY 505/515 TG	Lipid	Fluorescent Dye
18:1-6:0 DNP-C11 BODIPY 505/515 TG is a fluorescently-labeled triglyceride that can be used to study the effects of phosphoinositides (Ex/Em = 495/503 nm) .

HY-N2078R

Yamogenin (Standard) Neodiosgenin (Standard)	Structural Classification other families Plants Steroids Source Classification	Reference Standards LXR Apoptosis Fatty Acid Synthase (FASN) Reactive Oxygen Species (ROS)
Yamogenin (Standard) is the analytical standard of Yamogenin. This product is intended for research and analytical applications. Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC₅₀ of 1421.92 μg/mL. Yamogenin can be studied in research on gastric cancer .

HY-N11551

Salvifaricin	Artemisia frigida Willd. Terpenoids Labiatae Diterpenoids Plants Source Classification	Others
Salvifaricin is an orally active diterpenoid compound that can be isolated from Salvia leucantha Cav. and Salvia hispanica L.. Salvifaricin significantly reduces fasting blood glucose and serum triglyceride (TG) levels, and has anti-diabetic effect .

HY-N2118R

Bilobetin (Standard)	Structural Classification Flavonoids Ginkgoaceae Phenols Polyphenols Plants Biflavones Ginkgo biloba Source Classification	Reference Standards PPAR PKA Akt p38 MAPK ERK
Bilobetin (Standard) is the analytical standard of Bilobetin. This product is intended for research and analytical applications. Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-112540AR

Acetoacetic acid lithium (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Acetoacetic acid (lithium) (Standard) is the analytical standard of Acetoacetic acid (lithium). This product is intended for research and analytical applications. Acetoacetic acid lithium is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid lithium induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid lithium can be used to study metabolic diseases .

HY-N8353

Stachybotramide	Natural Products Microorganisms Source Classification	Others
Stachybotramide is a natural fungal metabolite with the property of modulating the activity of cholesteryl ester transfer protein (CETP). Stachybotramide stimulates the transfer of cholesteryl esters (CE) from high-density lipoprotein (HDL) to very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), increasing the transfer efficiency by 1.3- to 1.5-fold. Stachybotramide slightly reduced the transfer of cholesteryl esters from LDL and VLDL to HDL at 0.5 mM. The effect of Stachybotramide on the transfer of triglycerides (TG) from HDL was not significant. By these results, Stachybotramide was shown to preferentially stimulate the CETP-mediated transfer of cholesteryl esters from HDL to VLDL and LDL .

Cat. No.	Product Name	Chemical Structure

HY-N0368S

Linalool-d3 1 Publications Verification
Linalool-d₃ is the deuterium labeled Linalool . Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity .Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome .

HY-146799S

15:0-18:1-15:0 TG-d7
15:0-18:1-15:0 TG-d₇ is deuterium labeled 15:0-18:1-15:0 TG.

HY-146917S

20:0-20:1-20:0 TG-d5
20:0-20:1-20:0 TG-d₅ is deuterium labeled 20:0-20:1-20:0 TG.

HY-146914S

16:0-18:0-16:0 TG-d5
16:0-18:0-16:0 TG-d₅ is deuterium labeled 16:0-18:0-16:0 TG.

HY-146726S

Tripentadecanoin-d29
Tripentadecanoin-d₂₉ is the deuterium labeled Tripentadecanoin.

HY-W015600S

2-Acetamidophenol-d3

2-Acetamidophenol-d₃ (Orthocetamol-d₃) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .

HY-146913S

15:0-18:1-15:0 TG-d5
15:0-18:1-15:0 TG-d₅ is deuterium labeled 15:0-18:1-15:0 TG.

HY-163163S

18:1-21:2-18:1 TG-d5
18:1-21:2-18:1 TG-d5 is deuterium labeled 18:1-21:2-18:1 TG .

HY-14956S

Nemonoxacin-d3

Nemonoxacin-d₃ is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .

HY-163164S

18:1-17:1-18:1 TG-d5
18:1-17:1-18:1 TG-d5, 1,3-dioleoyl-2-heptadec-10Z-enoyl-glycerol-d5, is a deuterated substance .

HY-163165S

16:0-19:2-16:0 TG-d5
16:0-19:2-16:0 TG-d₅ is the deuterium labeled triacylglycerols.

HY-146915S

17:0-17:1-17:0 TG-d5
17:0-17:1-17:0 TG-d₅ is deuterium labeled 17:0-17:1-17:0 TG.

HY-146912S

14:0-16:1-14:0 TG-d5
14:0-16:1-14:0 TG-d₅ is deuterium labeled 14:0-16:1-14:0 TG.

HY-146916S

19:0-12:0-19:0 TG-d5
19:0-12:0-19:0 TG-d₅ is deuterium labeled 19:0-12:0-19:0 TG.

HY-163166S

18:1-19:2-18:1 TG-d5
18:1-19:2-18:1 TG-d₅ is a deuterium labeled 18:1-19:2-18:1 TG .

HY-14956S2

Nemonoxacin-d4

Nemonoxacin-d₄ is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .

HY-10409S

Fedratinib-d9

Fedratinib-d₉ (TG-101348-d₉) is deuterium labeled Fedratinib. Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC₅₀s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces cancer cell apoptosis and has the potential for myeloproliferative disorders research .

HY-14956S1

Nemonoxacin-d3-1

Nemonoxacin-d₃-1 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .

HY-115705

1,2,3-Tri-10(Z)-heptadecenoyl glycerol
1,2,3-Tri-10(Z)-heptadecenoyl glycerol (TG(17:1/17:1/17:1)) is a biochemical assay reagent, which can be used as an internal standard for the quantification of biological triglyceride .

HY-146737S

Tripentadecanoin-d5
Tripentadecanoin-d₅ is the deuterium labeled Tripentadecanoin.

HY-151997S

1,2-Dioleoyl-3-lauroyl-rac-glycerol-13C3
1,2-Dioleoyl-3-lauroyl-rac-glycerol- ¹³C₃ is the ¹³C-labeled 1,2-Dioleoyl-3-lauroyl-rac-glycerol (HY-165089), 1,2-Dioleoyl-3-lauroyl-rac-glycerol (1,2-Olein-3-laurin) is a triglyceride identified by specific analytical methods in human milk, infant formula, other mammalian milk, and vegetable oils, with specific structural and distribution characteristics.

HY-115705S

1,2,3-Tri-10(Z)-Heptadecenoyl Glycerol-d5
1,2,3-Tri-10(Z)-Heptadecenoyl Glycerol-d₅ is the deuterium labeled 1,2,3-Tri-10(Z)-Heptadecenoyl Glycerol .

HY-182556S

16:0-17:1-16:0 TG-d5
16:0-17:1-16:0 TG-d₅ is the deuterium labeled 16:0-17:1-16:0 TG.

HY-181634S

16:0-15:1-16:0 TG-d5
16:0-15:1-16:0 TG-d₅ is the deuterium labeled 16:0-15:1-16:0 TG.

HY-182554S

14:0-17:1-14:0 TG-d5
14:0-17:1-14:0 TG-d₅ is the deuterium labeled 14:0-17:1-14:0 TG.

HY-182544S

14:0-13:0-14:0 TG-d5
14:0-13:0-14:0 TG-d₅ is the deuterium labeled 14:0-13:0-14:0 TG.

HY-W710512

Propane-1,2,3-triyl tritricosanoate-d5

Propane-1,2,3-triyl tritricosanoate-d₅ (Glycerol Tritricosanoate-d₅) is deuterium labeled Propane-1,2,3-triyl tritricosanoate. 1,2,3-Tritricosanoyl glycerol is a triacylglycerol that contains tricosanoic acid (HY-W009081) at the sn-1, sn-2, and sn-3 positions. It has been used as an internal standard for the quantification of fatty acids in the triglyceride component of human aortic endothelial cells (HAECs) grown in media supplemented with stearic and/or oleic acid.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks