Acetoacetic acid lithium
Based on 5 publication(s) in Google Scholar
Acetoacetic acid lithium is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid lithium induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid lithium can be used to study metabolic diseases.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 3483-11-2
- Formula: C4H5LiO3
- Molecular Weight:108.02
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Publications Citing Use of MedChemExpress (MCE) Acetoacetic acid lithium
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Biological Activity
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Human Endogenous Metabolite |
In the bovine hepatocyte experiment, acetoacetic acid lithium (0.6, 2.4, 4.8 mM; 24 h) dose-dependently reduces the mRNA expression and enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increases the malondialdehyde (MDA) content, induced oxidative stress, and downregulates the mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and low-density lipoprotein receptor (LDLR), inhibits the assembly of very low-density lipoprotein (VLDL), and leads to the accumulation of intracellular triglycerides (TG) and a decrease in the VLDL content in the culture medium[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Bovine hepatocytes
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Concentration:0 (control), 0.6 mM, 2.4 mM, 4.8 mM
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Incubation Time:24 h
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Result:Significantly downregulated the mRNA expression of antioxidant enzymes (SOD, CAT, GSH-Px) and VLDL-related proteins (ApoB100, ApoE, LDLR) in a dose-dependent manner compared to the control group.
Increased intracellular malondialdehyde (MDA) content, a marker of oxidative stress, while the activities of SOD, CAT, and GSH-Px were reduced.
Resulted intracellular triglyceride (TG) accumulation, and significantly decreased the secretion of VLDL into the culture medium in a dose-dependent manner.
Chemical Information
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CAS No. 3483-11-2
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Appearance Solid
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Molecular Weight 108.02
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Formula C4H5LiO3
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Color White to off-white
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SMILES
CC(CC(O[Li])=O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Metab
β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice. [Abstract]2025 Jul;7(7):1330-1343. PMID: 40410577 -
J Nanobiotechnology
The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation. [Abstract]2022 Mar 9;20(1):120. PMID: 35264201 -
Am J Physiol Cell Physiol
Acetoacetate and D- and L-β-hydroxybutyrate have distinct effects on basal and insulin-stimulated glucose uptake in L6 skeletal muscle cells. [Abstract]2024 Jun 1;326(6):C1710-C1720. PMID: 38708524
Acetoacetic acid lithium purchased from MedChemExpress. Usage Cited in: Am J Physiol Cell Physiol. 2024 Jun 1;326(6):C1710-C1720. [Abstract]
Acetoacetic acid sodium (1 mM; 3 h) showed no effect on theexpression of ACAT or SCOT in L6 rat myotubes.
Acetoacetic acid lithium purchased from MedChemExpress. Usage Cited in: Am J Physiol Cell Physiol. 2024 Jun 1;326(6):C1710-C1720. [Abstract]
Acetoacetic acid sodium (0.2, 1 mM; 3 h) showed significantly increased thebasal translocation of GLUT4 to the membrane relative toglucose in 0.2 mM, but no differences were found for the other condi-tions in L6 GLUT4 mycmyotubes.
Acetoacetic acid lithium purchased from MedChemExpress. Usage Cited in: Am J Physiol Cell Physiol. 2024 Jun 1;326(6):C1710-C1720. [Abstract]
Acetoacetic acid sodium (0.2, 1 mM; 3 h; at the end ofthe 3 h treatment, 10 or 100 nM insulin for 20 min) decreased thebasal translocation of GLUT4 to the membrane in 0.2 mM with 100 nM insulin in L6 GLUT4 mycmyotubes.
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J Leukoc Biol
2023 Jun 1;113(6):577-587. PMID: 36999365 -
Solvent & Solubility
H2O : 100 mg/mL (925.75 mM; Need ultrasonic)
DMSO : 1.54 mg/mL (14.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 9.2575 mL | 46.2877 mL | 92.5755 mL | 231.4386 mL |
| 5 mM | 1.8515 mL | 9.2575 mL | 18.5151 mL | 46.2877 mL | |
| 10 mM | 0.9258 mL | 4.6288 mL | 9.2575 mL | 23.1439 mL | |
| H2O | 15 mM | 0.6172 mL | 3.0858 mL | 6.1717 mL | 15.4292 mL |
| 20 mM | 0.4629 mL | 2.3144 mL | 4.6288 mL | 11.5719 mL | |
| 25 mM | 0.3703 mL | 1.8515 mL | 3.7030 mL | 9.2575 mL | |
| 30 mM | 0.3086 mL | 1.5429 mL | 3.0858 mL | 7.7146 mL | |
| 40 mM | 0.2314 mL | 1.1572 mL | 2.3144 mL | 5.7860 mL | |
| 50 mM | 0.1852 mL | 0.9258 mL | 1.8515 mL | 4.6288 mL | |
| 60 mM | 0.1543 mL | 0.7715 mL | 1.5429 mL | 3.8573 mL | |
| 80 mM | 0.1157 mL | 0.5786 mL | 1.1572 mL | 2.8930 mL | |
| 100 mM | 0.0926 mL | 0.4629 mL | 0.9258 mL | 2.3144 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Acetoacetic acid lithium Related Classifications
HY-112540A Related Classifications
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