2. PI3K/Akt/mTOR
  3. PI3K
  4. TG 100713

TG 100713 

Cat. No.: HY-13514 Purity: 99.49%
COA Handling Instructions

TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively.

For research use only. We do not sell to patients.

TG 100713 Chemical Structure

TG 100713 Chemical Structure

CAS No. : 925705-73-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 77 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 410 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All PI3K Isoform Specific Products:

View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • Biological Activity

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  • References

  • Customer Review

Description

TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively[1].

IC50 & Target[1]

PI3Kδ

24 nM (IC50)

PI3Kγ

50 nM (IC50)

PI3Kα

165 nM (IC50)

PI3Kβ

215 nM (IC50)

In Vitro

TG100713 (10 μM; 48 or 72 h) strongly inhibits endothelial cell (EC) proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

254.25

Appearance

Solid

Formula

C12H10N6O
CAS No.
SMILES

OC1=CC=CC(C2=NC3=C(N)N=C(N)N=C3N=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 6.41 mg/mL (25.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9331 mL 19.6657 mL 39.3314 mL
5 mM 0.7866 mL 3.9331 mL 7.8663 mL
10 mM 0.3933 mL 1.9666 mL 3.9331 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.49%

COA (246 KB) HNMR (266 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TG 100713925705-73-3TG100713TG-100713PI3KPhosphoinositide 3-kinasePI3KδPI3KγPI3KαPI3KβisoformInhibitorinhibitorinhibit

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