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Results for "

Type I ROS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Reactive Oxygen Species (ROS) (10) Akt (1) Aldose Reductase (1) Apoptosis (3) Atg8/LC3 (1) Autophagy (2) Bcr-Abl (1) Beclin1 (1) c-Myc (1) Caspase (1) CDK (2) Collagen (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Ferroptosis (1) HIF/HIF Prolyl-Hydroxylase (1) IRE1 (1) JAK (1) JNK (2) MMP (1) mTOR (1) NF-κB (2) p38 MAPK (1) PDGFR (1) PERK (1) Photosensitizer (2) PROTACs (1) SOD (1) STAT (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (2)

By Targets:

Reactive Oxygen Species (ROS) (10)

Akt (1)

Aldose Reductase (1)

Apoptosis (3)

Atg8/LC3 (1)

Autophagy (2)

Bcr-Abl (1)

Beclin1 (1)

c-Myc (1)

Caspase (1)

CDK (2)

Collagen (1)

Endogenous Metabolite (1)

Epigenetic Reader Domain (1)

Ferroptosis (1)

HIF/HIF Prolyl-Hydroxylase (1)

IRE1 (1)

JAK (1)

JNK (2)

MMP (1)

mTOR (1)

NF-κB (2)

p38 MAPK (1)

PDGFR (1)

PERK (1)

Photosensitizer (2)

PROTACs (1)

SOD (1)

STAT (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (9)

Cardiovascular Disease (1)

Inflammation/Immunology (3)

Metabolic Disease (2)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: ROS Kinase Reactive Oxygen Species (ROS) C-type Lectin-like Receptors (CTLRs) PCSK9 Scavenger Receptor Class B type I (SR-BI）

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19696B

Tauroursodeoxycholate dihydrate 100+ Cited Publications Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt	Neurological Disease Metabolic Disease Inflammation/Immunology
Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits *ROS* generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .

HY-N2282

Zingiberen newsaponin Zingiberensis newsaponin	Aldose Reductase JAK STAT Autophagy Apoptosis NF-κB SOD Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Zingiberen Newsaponin (Zingiberensis newsaponin) is an orally active type of steroid saponin compound. Zingiberen Newsaponin exerts anti-hepatocellular carcinoma (HCC) effects by inhibiting autophagy and the AKR1C1/JAK2/STAT3 pathway. Zingiberen Newsaponin activates oxidative stress (upregulates *ROS* and MDA) and mitochondrial pathways, promoting cancer cell apoptosis. Zingiberen Newsaponin alleviates cerebral ischemia-reperfusion (I/R) injury by decreasing the concentration of pro-inflammatory cytokines and inhibits NF-κB. Zingiberen Newsaponin can enhance the activity of SOD, eliminate free radicals and protect nerve cells. Zingiberen Newsaponin induces platelet aggregation .

HY-123450

S116836	Bcr-Abl Apoptosis PDGFR	Cancer
S116836, a potent, orally active BCR-ABL tyrosine kinase inhibitor, blocks both wild-type as well as T315I Bcr-Abl. S116836 arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells. S116836 also inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β. Antitumor activies . S116836 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N12653

Exserohilone (-)-Exserohilone	Reactive Oxygen Species (ROS)	Metabolic Disease
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced *ROS* generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .

HY-168097

Ferroptosis inducer-6	Ferroptosis Reactive Oxygen Species (ROS)	Cancer
Ferroptosis inducer 6 (6d) is a ferroptosis inducer with high potency for type I/-II photodynamic therapy by inducing ROS generation, oxidative stress and mitochondrial damage. Ferroptosis inducer 6 has anti-tumor activity .

HY-168854

TBC-1	Photosensitizer Reactive Oxygen Species (ROS)	Cancer
TBC-1 is a chlorophyll-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT). TBC-1 efficiently generats Type-I *ROS* and endoplasmic reticulum targeting ability. TBC-1 shows biocompatibility and PDT efficiency in vitro under both normoxia and hypoxia .

HY-176724

ZnPc-O3-JQ1	Epigenetic Reader Domain Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase	Cancer
ZnPc-O3-JQ1 is a light-triggered BRD4 degrader. Under illumination, ZnPc-O3-JQ1 generates reactive oxygen species (ROS) that degrades BRD4. The degradation of BRD4 results in downregulation of HIF-1α, thereby counteracting the photodynamic therapy (PDT) resistance induced by tumor hypoxia. ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 consists of three parts: BRD4 ligand (HY-78695); Linker (HY-W040165); Photosensitizer (HY-176725) .

HY-183570

Antitumor photosensitizer-11	Photosensitizer Reactive Oxygen Species (ROS)	Cancer
Antitumor photosensitizer-11 is a type-I carbazole/benzindolium photosensitizer with antitumor activity. Antitumor photosensitizer-11 induces *ROS* generation via a type-I pathway, forming superoxide anions and hydroxyl radicals. Antitumor photosensitizer-11 triggers immunogenic cell death in cancer cells via enhanced oxidative stress. Antitumor photosensitizer-11 exhibits antiproliferative activity in normoxic and hypoxic environments, inhibits breast cancer tumor growth in vivo, and promotes dendritic cell maturation and T cell infiltration. Antitumor photosensitizer-11 can be used for the research of cancer, such as breast cancer .

HY-181906

ZnPc-PEG2-VH032	PROTACs Reactive Oxygen Species (ROS) CDK	Cancer
ZnPc-PEG2-VH032 is a VHL-pathway-dependent photodegradation targeting chimera (PDTAC) and cytotoxic agent. ZnPc-PEG2-VH032 (HY-120217) binds to the VHL ligand domain, and then specifically degrades VHL under light irradiation, a process independent of non-specific *ROS*-mediated protein damage. ZnPc-PEG2-VH032 uses Zinc phthalocyanine (HY-19204) as a photosensitizer, and generates *ROS* via type I and type II photodynamic pathways under 680 nm LED irradiation. On one hand, it targets and degrades the bound VHL protein through *ROS; on the other hand, it exerts direct photodynamic cytotoxicity. Meanwhile, the degradation of VHL downregulates the phosphorylation level of CDK2/4, induces cell cycle arrest in tumor cells, further enhances the sensitivity of tumor cells to oxidative damage caused by ROS, and achieves a synergistic anti-tumor effect. ZnPc-PEG2-VH032 exerts significant in vivo efficacy in an orthotopic mouse model of non-muscle invasive bladder cancer (NMIBC*) .

HY-P11656

α-Neoendorphin (porcine)	mTOR Beclin1 Autophagy Atg8/LC3 Reactive Oxygen Species (ROS) MMP p38 MAPK PERK JNK Collagen	Inflammation/Immunology
α-Neoendorphin porcine is a peptide. α-Neoendorphin porcine effectively alleviates UVB-induced skin photoaging via activating mTOR-Beclin-1-mediated autophagy, reducing UVB-triggered *ROS* production, inhibiting the MAPK pathway and MMP activity, and promoting type I procollagen synthesis. α-Neoendorphin porcine exerts anti-aging and anti-wrinkle effects on skin cells. α-Neoendorphin porcine can be used in studies related to skin photoaging .

HY-183797

Antitumor agent-218		Cancer
Antitumor agent-218 is an aggregation-induced emission (AIE)-based photosensitizer. Antitumor agent-218 selectively accumulates in the endoplasmic reticulum, and generates ROS within the endoplasmic reticulum upon irradiation to induce necroptosis of tumor cells. Antitumor agent-218 can be used in cancer-related research .

HY-180124

CDK8-IN-20	CDK Wnt β-catenin c-Myc Reactive Oxygen Species (ROS)	Cancer
CDK8-IN-20 (Compound 67j) is a selective, potent and orally active type I CDK8 inhibitor with an IC₅₀ of 70.5 nM. CDK8-IN-20 shows IC₅₀ values of 147.8, 726.9 and 217.4 nM for homologous kinase CDK19, CDK7 and CDK9. CDK8-IN-20 can inhibit the Wnt/β-catenin pathway and downregulate the expression of β-catenin, Cyclin D1, and c-Myc. CDK8-IN-20 can induce *ROS* production and cause G2/M and S phase arrest. CDK8-IN-20can be used for the research of cancer, such as colon cancer .

Cat. No.	Product Name	Target	Research Area

HY-P11656

α-Neoendorphin (porcine)	mTOR Beclin1 Autophagy Atg8/LC3 Reactive Oxygen Species (ROS) MMP p38 MAPK PERK JNK Collagen	Inflammation/Immunology
α-Neoendorphin porcine is a peptide. α-Neoendorphin porcine effectively alleviates UVB-induced skin photoaging via activating mTOR-Beclin-1-mediated autophagy, reducing UVB-triggered *ROS* production, inhibiting the MAPK pathway and MMP activity, and promoting type I procollagen synthesis. α-Neoendorphin porcine exerts anti-aging and anti-wrinkle effects on skin cells. α-Neoendorphin porcine can be used in studies related to skin photoaging .

Tauroursodeoxycholate dihydrate 100+ Cited Publications Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt
Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits *ROS* generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .

Zingiberen newsaponin Zingiberensis newsaponin	Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Dioscorea Zingiberensis C.H.Wright Plants Disease Research Fields Dioscoreaceae Source Classification	Aldose Reductase JAK STAT Autophagy Apoptosis NF-κB SOD Reactive Oxygen Species (ROS)
Zingiberen Newsaponin (Zingiberensis newsaponin) is an orally active type of steroid saponin compound. Zingiberen Newsaponin exerts anti-hepatocellular carcinoma (HCC) effects by inhibiting autophagy and the AKR1C1/JAK2/STAT3 pathway. Zingiberen Newsaponin activates oxidative stress (upregulates *ROS* and MDA) and mitochondrial pathways, promoting cancer cell apoptosis. Zingiberen Newsaponin alleviates cerebral ischemia-reperfusion (I/R) injury by decreasing the concentration of pro-inflammatory cytokines and inhibits NF-κB. Zingiberen Newsaponin can enhance the activity of SOD, eliminate free radicals and protect nerve cells. Zingiberen Newsaponin induces platelet aggregation .

Exserohilone (-)-Exserohilone	Microorganisms Antibiotics Other Antibiotics Source Classification	Reactive Oxygen Species (ROS)
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced *ROS* generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .

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