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UBR E3 ligase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Polo-like Kinase (PLK) (1) PROTACs (3) α-synuclein (1)
By Research Areas:	Cancer (1) Neurological Disease (1)
Oligonucleotides:	Pegylated Lipids (1)

Inhibitors & Agonists

Peptides

Antibodies

Oligonucleotides

Targets Recommended: Ligands for E3 Ligase E3 Ligase Ligand-Linker Conjugates E1/E2/E3 Enzyme ByeTAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-180976

Arg-PEG1-Tαsyn	PROTACs α-synuclein	Neurological Disease
Arg-PEG1-Tαsyn is an α-syn PROTAC degrader with a DC₅₀ of 0.28 μM in U251 cells. Arg-PEG1-Tαsyn employs the amino acid arginine (Arg) as the E3 ligase UBR1 ligand and a benzothiazole-aniline variant as the warhead for α-syn. Arg-PEG1-Tαsyn significantly reduces α-syn aggregates and improves the dopaminergic neuronal impairment and the locomotion with safety profile in vivo.Arg-PEG1-Tαsyn shows the high degradation effect in mammalian cells for both wild-type α-syn and the α-syn (A53T) mutant. Arg-PEG1-Tαsyn can be used for Parkinson’s disease research .

HY-180958

Chlorohexane-PEG-clozapine	PROTACs	Others
Chlorohexane-PEG-clozapine is a HaloTag PROTAC degrader based on Clozapine (HY-14539). Chlorohexane-PEG-clozapine leads to a significant decrease in the luminescence intensity and protein level of Halo-Eluc .

HY-180989

PROTAC PLK1 Degrader-2	PROTACs Polo-like Kinase (PLK) Apoptosis	Cancer
PROTAC PLK1 Degrader-2 (Compound NC1) is a PLK1 PROTAC degrader with an K_d of 6.06 μM. PROTAC PLK1 Degrader-2 significantly inhibits the proliferation of HeLa cells, induces cell cycle arrest and apoptosis. PROTAC PLK1 Degrader-2 exhibits significant anti-tumor activity in a HeLa cell xenograft tumor mouse model. PROTAC PLK1 Degrader-2 can be used for the study of cervical cancer.

Cat. No.	Product Name	Target	Research Area

HY-180989

PROTAC PLK1 Degrader-2	PROTACs Polo-like Kinase (PLK) Apoptosis	Cancer
PROTAC PLK1 Degrader-2 (Compound NC1) is a PLK1 PROTAC degrader with an K_d of 6.06 μM. PROTAC PLK1 Degrader-2 significantly inhibits the proliferation of HeLa cells, induces cell cycle arrest and apoptosis. PROTAC PLK1 Degrader-2 exhibits significant anti-tumor activity in a HeLa cell xenograft tumor mouse model. PROTAC PLK1 Degrader-2 can be used for the study of cervical cancer.

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810024

	Ubr3 Antibody (YA9368) KIAA2024, ZNF650, UBR3, E3 ubiquitin-protein ligase UBR3, N-recognin-3, RING-type E3 ubiquitin transferase UBR3, Ubiquitin-protein ligase E3-alpha-3, Ubiquitin-protein ligase E3-alpha-III, Zinc finger protein 650	WB, IP, ELISA	human, mouse, rat
	Ubr3 Antibody (YA9368) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ubr3.

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Cat. No.	Product Name		Classification

HY-180958

Chlorohexane-PEG-clozapine		Pegylated Lipids
Chlorohexane-PEG-clozapine is a HaloTag PROTAC degrader based on Clozapine (HY-14539). Chlorohexane-PEG-clozapine leads to a significant decrease in the luminescence intensity and protein level of Halo-Eluc .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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