Ubr3 Antibody (YA9368)
(Synonyms: KIAA2024, ZNF650, UBR3, E3 ubiquitin-protein ligase UBR3, N-recognin-3, RING-type E3 ubiquitin transferase UBR3, Ubiquitin-protein ligase E3-alpha-3, Ubiquitin-protein ligase E3-alpha-III, Zinc finger protein 650)
Based on 1 Customer Validation
Ubr3 Antibody (YA9368) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ubr3.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IP, ELISA
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Reactivity :
human, mouse, rat
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1-2μg per 100-500μg Total protein | 1:50-3000 |
Product Details
Ubr3 Antibody (YA9368) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ubr3.
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Host Mouse
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Species Reactivityhuman, mouse, rat
A synthesized peptide derived from human Ubr3.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
Ubr3 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A[1].
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Subcellular Localization
Membrane
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Isoforms & Post-Translational Modification
Ubr3 has 4 isoforms, Q6ZT12-1: amino acid length is 1888, molecular weight is 212433 Da (predicted); Q6ZT12-2: amino acid length is 709, molecular weight is 80668 Da (predicted); Q6ZT12-3: amino acid length is 394, molecular weight is 45533 Da (predicted); Q6ZT12-4: amino acid length is 1917, molecular weight is 215971 Da (predicted).
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Subunit
Interacts with UBE2A and UBE2B
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SwissProt ID
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Synonyms
KIAA2024, ZNF650, UBR3, E3 ubiquitin-protein ligase UBR3, N-recognin-3, RING-type E3 ubiquitin transferase UBR3, Ubiquitin-protein ligase E3-alpha-3, Ubiquitin-protein ligase E3-alpha-III, Zinc finger protein 650
Documentation
References
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