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Cat. No.: HY-180958

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Chlorohexane-PEG-clozapine

Chlorohexane-PEG-clozapine is a HaloTag PROTAC degrader based on Clozapine (HY-14539). Chlorohexane-PEG-clozapine leads to a significant decrease in the luminescence intensity and protein level of Halo-Eluc.
(Pink: Ligands for Target Protein for PROTAC Target protein ligand; Blue: Ligands for E3 Ligase ligand (HY-14539); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3104316-26-6
Formula: C₂₇H₃₆Cl₂N₄O₂
Molecular Weight:519.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Chlorohexane-PEG-clozapine Chemical Structure

CAS No.: 3104316-26-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chlorohexane-PEG-clozapine is a HaloTag PROTAC degrader based on Clozapine (HY-14539). Chlorohexane-PEG-clozapine leads to a significant decrease in the luminescence intensity and protein level of Halo-Eluc^[1]. (Pink: Ligands for Target Protein for PROTAC Target protein ligand; Blue: Ligands for E3 Ligase ligand (HY-14539); Black: linker).

All PROTACs Isoforms :

Chemical Information

CAS No. 3104316-26-6
Molecular Weight 519.51
Formula C₂₇H₃₆Cl₂N₄O₂
SMILES

ClCCCCCCOCCOCCN1CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Takano R, et al. Clozapine as an E3 Ligand for PROTAC Technology. ACS Med Chem Lett. 2025 Jan 8;16(2):258-262. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
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References

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Chlorohexane-PEG-clozapine

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Chlorohexane-PEG-clozapine Related Classifications

HY-180958 Related Classifications