13 Results for "

VEGF isoform

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "VEGF isoform" in MCE Product Catalog:

62
62 Publications Verification
Cat. No.: HY-P9906
CAS No.: 216974-75-3
Synonyms: Anti-Human VEGF, Humanized Antibody

Target:  

VEGFR

Research Areas:  

Cancer

Bevacizumab, a humanized IgG1 monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity.
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62
62 Publications Verification
Cat. No.: HY-P9906A
CAS No.: 216974-75-3

Target:  

VEGFR

Research Areas:  

Cancer

Bevacizumab, a humanized IgG1 monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity .
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13
13 Cited Publications
Cat. No.: HY-117661
CAS No.: 1818389-84-2
Target:  

SRPK VEGFR

Research Areas:  

Cardiovascular Disease Cancer

SPHINX31 is a potent and selective SRPK1 inhibitor, with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 also decreases the mRNA expression of pro-angiogenic VEGF-A165a isoform. SPHINX31 can be used to research neovascular eye disease .
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1
1 Cited Publications
Cat. No.: HY-P9951A
CAS No.: 347396-82-1
Synonyms: RG-6321 (anti-VEGF)

Target:  

VEGFR

Research Areas:  

Cardiovascular Disease

Ranibizumab (RG-6321) (anti-VEGF) is a humanized anti-VEGF monoclonal antibody fragment and can recognize all VEGF-A isoforms (VEGF110, VEGF121, and VEGF165) . Ranibizumab (anti-VEGF) slows vision loss in vivo and is used for wet age-related macular degeneration (AMD) research .
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1
1 Cited Publications
Cat. No.: HY-P99905
CAS No.: 2375661-82-6
Synonyms: IBI302

Target:  

VEGFR

Efdamrofusp alfa is a bispecific fusion protein. Efdamrofusp alfa is capable of neutralizing both VEGF isoforms and C3b/C4b. Efdamrofusp alfa can be used for the research of neovascular age-related macular degeneration (nAMD) and other complement-related ocular conditions .
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1
1 Cited Publications
Cat. No.: HY-N4322
CAS No.: 130848-06-5
Decursinol angelate acts as a PKC activator and GDH inhibitor, with an IC50 of 1.432 μM against human GDH. Decursinol angelate activates PKC, downregulates PKCα and PKCβII isoforms, and exerts cytotoxic activity against cancer cells. Decursinol angelate binds to GDH and inhibits its enzymatic activity. Decursinol angelate inhibits VEGF-induced autophosphorylation of VEGFR2, downstream p42/44 ERK and JNK-MAPK signaling pathways, as well as the angiogenesis process. Decursinol angelate is applicable to research related to cancer and leukemia .
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Cat. No.: HY-P99830
CAS No.: 1227158-72-6
Synonyms: KH902
Conbercept (KH902) is a recombinant fusion protein composed of VEGFR-1 (second domain) and VEGFR-2 (third and fourth domains) regions fused to human IgG1 Fc. Conbercept is a VEGF inhibitor (IC50 = 8.8 pM) and is a soluble receptor decoy that blocks all isoforms of VEGF-A (Kd = 0.5 pM), VEGF-B (Kd = 8 pM), VEGF-C, and PlGF (Kd = 5 pM). Conbercept has anti-inflammatory effects, can lower the levels of VEGF, TNF-α and IL-6, and reduce the infiltration of inflammatory cells. Conbercept decreases tumor growth in several oncology studies. Conbercept can be used for various eye diseases such as polypoidal choroidal vasculopathy (PCV), diabetic macular edema (DME) and pathologic myopia choroidal neovascularization (pmCNV) .
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Cat. No.: HY-112547
CAS No.: 1034297-58-9
Synonyms: CRT0066051
Target:  

PKD

Research Areas:  

Others

CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis .
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Cat. No.: HY-19471
CAS No.: 1010440-84-2
Research Areas:  

Cancer

(rac)-ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (CDKs), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. (rac)-ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1α. (rac)-ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may become a potential agent for inhibiting NET .
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Cat. No.: HY-P73313
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NRP2; Neuropilin-2a(22); Neuropilin 2; Neuropilin-2b(0); VEGF165R2; NRP2 Protein; Vascular Endothelial Cell Growth Factor 165 Receptor 2; Neuropilin; Neuropilin-2; PRO2714; Receptor For VEGF165 And Semaphorins Class3; NPN2; Neuropilin 2, isoform CRA_i; NP
Species:  
Source:  
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Cat. No.: HY-P73315
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP2; Neuropilin-2a(22); Neuropilin 2; Neuropilin-2b(0); VEGF165R2; NRP2 Protein; Vascular Endothelial Cell Growth Factor 165 Receptor 2; Neuropilin; Neuropilin-2; PRO2714; Receptor For VEGF165 And Semaphorins Class3; NPN2; Neuropilin 2, isoform CRA_i; NP
Species:  
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Cat. No.: HY-P73314
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP2; Neuropilin-2a(22); Neuropilin 2; Neuropilin-2b(0); VEGF165R2; NRP2 Protein; Vascular Endothelial Cell Growth Factor 165 Receptor 2; Neuropilin; Neuropilin-2; PRO2714; Receptor For VEGF165 And Semaphorins Class3; NPN2; Neuropilin 2, isoform CRA_i; NP
Species:  
Source:  
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Cat. No.: HY-P705420
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP2; Neuropilin-2a(22); Neuropilin 2; Neuropilin-2b(0); VEGF165R2; NRP2 Protein; Vascular Endothelial Cell Growth Factor 165 Receptor 2; Neuropilin; Neuropilin-2; PRO2714; Receptor For VEGF165 And Semaphorins Class3; NPN2; Neuropilin 2, isoform CRA_i; NP
Species:  
Source:  
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