1010440-84-2
Chemical Structure
(rac)-ZK-304709
- CAS No.: 1010440-84-2
- Formula:C22H29ClN6O2
- Molecular Weight:444.96
IUPAC Name: 4-(3-chloro-5-(4-methylpiperazin-1-yl)benzamido)-N-cyclohexyl-1H-pyrazole-3-carboxamide
InChIKey: OALDDSAHYZPJQM-UHFFFAOYSA-N
SMILES: O=C(C1=NNC=C1NC(C2=CC(N3CCN(C)CC3)=CC(Cl)=C2)=O)NC4CCCCC4
Biological Activity: (rac)-ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (CDKs), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. (rac)-ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1α. (rac)-ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may become a potential agent for inhibiting NET[1].
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(rac)-ZK-304709 | (rac)-ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (CDKs), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. (rac)-ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1α. (rac)-ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may become a potential agent for inhibiting NET. | |||||||||||||||||||||
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