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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
WD repeat domain 5 (WDR5)
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "WD repeat domain 5 (WDR5)" in MCE Product Catalog:
15
15 Cited Publications
Cat. No.: HY-16993
CAS No.: 1801787-56-3
OICR-9429, a chemical probe, is high affinity WD repeat domain 5 (WDR5) inhibitor, competitively blocks WDR5 interaction with MLL protein via binding the central peptide-binding pocket of WDR5. OICR-9429 can suppress histone H3K4 trimethylation and can be used for the research of various cancers including non-MLL-rearranged leukaemia, colon, pancreatic, prostate cancer and bladder cancer (BCa) .
5
5 Cited Publications
WDR5-IN-4 (Compound C6) is a WIN site inhibitor of chromatin-associated WD repeat domain 5 protein (WDR5), Kd The value is 0.1 nM. WDR5-IN-4 is able to displace WDR5 from chromatin and reduce the expression of related genes, causing translation inhibition and nucleolar stress. Has anti-cancer effects .
WDR5-IN-5 is an orally active and selective inhibitor of WIN site of WD repeat domain 5 (WDR5). WDR5-IN-5 exhibits anti-proliferative activity towards cancer cells and good pharmacokinetics profile in mice. WDR5-IN-5 shows high affinity to WDR5 and the binding affinity Ki value <0.02 nM .
WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a Kd of <0.02 nM. WDR5-IN-1 inhibits MLL1 histone methyltransferase (HMT) activity with an IC50 of 2.2 nM. WDR5-IN-1 diminishes MYC recruitment at WDR5-displaced genes and exhibits potent anti-proliferative effects in CHP-134 (neuroblastoma) and Ramos (Burkitt’s lymphoma) lines .
Cat. No.: HY-100869
CAS No.: 2097887-20-0
MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM .
MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM .
Cat. No.: HY-100869B
Purity: 99.83%
MM-589 (racemic mixture) TFA, is a racemic mixture of MM-589 TFA (HY-100869A). MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM .
Cat. No.: HY-P703615
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: WDR5; WD repeat domain 5; CFAP89; BIG‑3; SWD3; Cilia And Flagella Associated Protein 89; WD repeat‑Containing Protein 5; BMP2‑Induced 3‑Kb Gene Protein; BMP‑2‑Induced Gene 3 Kb; BIG3; SWD3, Set1c WD40 repeat Protein, Homolog (S. Cerevisiae); SWD3, Set1c W
Species:
Human
Source:
E. coli
Cat. No.: HY-P702880
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: WDR5; WD repeat domain 5; CFAP89; BIG‑3; SWD3; Cilia And Flagella Associated Protein 89; WD repeat‑Containing Protein 5; BMP2‑Induced 3‑Kb Gene Protein; BMP‑2‑Induced Gene 3 Kb; BIG3; SWD3, Set1c WD40 repeat Protein, Homolog (S. Cerevisiae); SWD3, Set1c W
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702881
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: WDR5; WD repeat domain 5; CFAP89; BIG‑3; SWD3; Cilia And Flagella Associated Protein 89; WD repeat‑Containing Protein 5; BMP2‑Induced 3‑Kb Gene Protein; BMP‑2‑Induced Gene 3 Kb; BIG3; SWD3, Set1c WD40 repeat Protein, Homolog (S. Cerevisiae); SWD3, Set1c W
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
