1801787-56-3
Chemical Structure
OICR-9429
- CAS No.: 1801787-56-3
- Formula:C29H32F3N5O3
- Molecular Weight:555.59
IUPAC Name: N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
InChIKey: DJOVLOYCGXNVPI-UHFFFAOYSA-N
SMILES: O=C(C1=CNC(C=C1C(F)(F)F)=O)NC2=CC(C3=CC(CN4CCOCC4)=CC=C3)=CC=C2N5CCN(C)CC5
Biological Activity: OICR-9429, a chemical probe, is high affinity WD repeat domain 5 (WDR5) inhibitor, competitively blocks WDR5 interaction with MLL protein via binding the central peptide-binding pocket of WDR5. OICR-9429 can suppress histone H3K4 trimethylation and can be used for the research of various cancers including non-MLL-rearranged leukaemia, colon, pancreatic, prostate cancer and bladder cancer (BCa) [1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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OICR-9429 | 98.90% | OICR-9429, a chemical probe, is high affinity WD repeat domain 5 (WDR5) inhibitor, competitively blocks WDR5 interaction with MLL protein via binding the central peptide-binding pocket of WDR5. OICR-9429 can suppress histone H3K4 trimethylation and can be used for the research of various cancers including non-MLL-rearranged leukaemia, colon, pancreatic, prostate cancer and bladder cancer (BCa) . | ||||||||||||||||||||
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-
Similarity Score 0.89
HY-16994OICR-0547 -
Similarity Score 0.86
HY-141798OICR-9429-N-C2-NH2 -
Similarity Score 0.72
HY-168488WDR5 ligand 2 -
Similarity Score 0.63
HY-184594WDR5 ligand 4 -
Similarity Score 0.62
HY-141799Dimethyl-F-OICR-9429-COOH -
Similarity Score 0.55
HY-148829MS40 -
Similarity Score 0.52
HY-137498EBOV/MARV-IN-1 -
Similarity Score 0.51
HY-141797MS33 -
Similarity Score 0.51
HY-101034CHMFL-ABL/KIT-155 -
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