2 Results for "

Z-Phe-Phe-FMK

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Z-Phe-Phe-FMK" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-115733
CAS No.: 108005-94-3
Purity:  98.27%
Synonyms: (Rac)-Z-Phe-Phe-FMK
Target:  

Cathepsin

Research Areas:  

Cancer

Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
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Cat. No.: HY-141867
CAS No.: 105608-85-3
Purity:  98.71%
Synonyms: Z-Phe-Phe-FMK
Z-FF-FMK (Z-Phe-Phe-FMK) is a cell-permeable, irreversible, and cysteine protease inhibitor targeting cathepsin-L. Z-FF-FMK inhibits angiotensin II-induced MEK activation in vascular walls, aortic medial remodeling, blood pressure elevation, and upregulation of cystatin C in aortic walls. Z-FF-FMK prevents β-amyloid-mediated caspase-3 activation, poly (ADP-ribose) polymerase cleavage, DNA fragmentation, and apoptosis of cortical neurons (apoptosis). Z-FF-FMK can be used in research related to hypertension and Alzheimer's disease .
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