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Results for "

Zinc phthalocyanine

" in MedChemExpress (MCE) Product Catalog:

2

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Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-19204
    Zinc phthalocyanine

    ZnPc

    		 Ligands for Target Protein for PROTAC Reactive Oxygen Species (ROS) Apoptosis Caspase Cancer
    Zinc phthalocyanine (ZnPc) is commonly applied in industry (catalysts, photoconductors) and biomedical (photodynamic therapy, PDT). Zinc phthalocyanine can be used to photooxidise cyclohexane and is promising for research of solar-cell applications .
    Zinc phthalocyanine
  • HY-181906
    ZnPc-PEG2-VH032

    		PROTACs Reactive Oxygen Species (ROS) CDK Cancer
    ZnPc-PEG2-VH032 is a VHL-pathway-dependent photodegradation targeting chimera (PDTAC) and cytotoxic agent. ZnPc-PEG2-VH032 (HY-120217) binds to the VHL ligand domain, and then specifically degrades VHL under light irradiation, a process independent of non-specific ROS-mediated protein damage. ZnPc-PEG2-VH032 uses Zinc phthalocyanine (HY-19204) as a photosensitizer, and generates ROS via type I and type II photodynamic pathways under 680 nm LED irradiation. On one hand, it targets and degrades the bound VHL protein through ROS; on the other hand, it exerts direct photodynamic cytotoxicity. Meanwhile, the degradation of VHL downregulates the phosphorylation level of CDK2/4, induces cell cycle arrest in tumor cells, further enhances the sensitivity of tumor cells to oxidative damage caused by ROS, and achieves a synergistic anti-tumor effect. ZnPc-PEG2-VH032 exerts significant in vivo efficacy in an orthotopic mouse model of non-muscle invasive bladder cancer (NMIBC) .
    ZnPc-PEG2-VH032

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