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Results for "

airway obstruction

" in MedChemExpress (MCE) Product Catalog:
Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-108858
    Dornase alfa
    1 Publications Verification

    rhDNase

    		 DNA/RNA Synthesis Endonuclease Inflammation/Immunology
    Dornase alfa (rhDNase) is a recombinant human deoxyribonuclease I (rhDNase) that can specifically degrade extracellular DNA. Dornase alfa catalyzes the cleavage of DNA released by neutrophils in respiratory mucus, reduces sputum viscosity, thereby improving mucus clearance efficiency, reducing airway obstruction and alleviating inflammatory responses. Dornase alfa can be used to improve lung function (such as FEV_1) in cystic fibrosis (CF), reduce the risk of acute pulmonary exacerbations, and has good in vivo tolerability. Dornase alfa acts locally on the respiratory tract through aerosol inhalation, specifically improving the high viscosity of mucus caused by DNA accumulation and related respiratory symptoms .
    Dornase alfa
  • HY-105999
    APC 366

    		Ser/Thr Protease Inflammation/Immunology
    APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma .
    APC 366
  • HY-175873
    AD109

    		mAChR Adrenergic Receptor Inflammation/Immunology
    AD109 is a combination of the selective norepinephrine reuptake inhibitor Atomoxetine (HY-107370) and the antimuscarinic agent Aroxybutynin (HY-B0267C). AD109 shows orally active significantly and reduces the apnea-hypopnea index .
    AD109
  • HY-W747594
    SDZ PCO 400

    		Potassium Channel Neurological Disease
    SDZ PCO 400 is a potassium channel modulator that relaxes airway smooth muscle and reverses airway obstruction caused by intravenous bronchospasmodics .
    SDZ PCO 400
  • HY-105999A
    APC 366 hydrochloride

    		Ser/Thr Protease Inflammation/Immunology
    APC 366 hydrochloride is a selective inhibitor of mast cell trypsin activity. APC 366 hydrochloride is able to inhibit trypsin-induced histamine release in human tonsil and lung cells. APC 366 hydrochloride may have important applications in regulating allergic reactions and inflammation .
    APC 366 hydrochloride
  • HY-158333
    Tasuldine

    		Mucin Others
    Tasuldine is a mucolytic agent, which decreases the sialomucin content of mucus, improves mucociliary and cough clearance .
    Tasuldine
  • HY-129785
    CP-220629

    		Phosphodiesterase (PDE) Neurological Disease Inflammation/Immunology
    CP-220629 is a potent inhibitor of PDE4, with the IC50 of 0.44 μM. CP-220629 is efficacious in the guinea pig aerosolized antigen induced airway obstruction assay (ED50 2.0 mg/kg) .
    CP-220629
  • HY-165508
    Nesosteine free acid

    CO-1177 free acid

    		 Others Infection
    Nesosteine (CO-1177) free acid is a regulator of airway secretions that can improve the transport of respiratory mucus. Nesosteine free acid has the function of promoting mucociliary clearance and enhancing the efficiency of mucociliary clearance. Nesosteine free acid also increases the speed of mucus transport, which helps to accelerate the discharge of mucus in the respiratory tract, relieve airway obstruction, and improve respiratory function. Nesosteine free acid can be used to study respiratory diseases such as chronic bronchitis accompanied by abnormal mucus secretion .
    Nesosteine free acid

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