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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
alkoxyl
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "alkoxyl" in MCE Product Catalog:
Cat. No.: HY-164008
CAS No.: 2934622-03-2
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DTUN is a lipophilic hyponitrite radical initiator. DTUN decomposes to form lipophilic alkoxyl radicals that initiate phospholipid peroxidation in liposomal egg phosphatidylcholine. DTUN can be used as a tool for research of ferroptosis .
Cat. No.: HY-D3401
CAS No.: 3121511-17-6
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LHA585 is a fluorescent probe targeting the lipid hydrogen abstraction process for the early detection of ferroptosis (Ferroptosis). Its detection mechanism relies on the reactivity of its own 4-phenyl-3-methylbut-2-enyl moiety with biologically relevant oxidative radicals, including peroxyl radicals (ROO·), alkoxyl radicals (RO·), hydroxyl radicals (HO·), and peroxynitrite anions (ONOO−); upon hydrogen abstraction from this structure, radical rearrangement and radical cleavage occur, releasing a xanthene radical which converts into a highly fluorescent rhodamine dye in biological environments, thereby achieving a fluorescence turn-on ratio of up to 360-fold. LHA585 is non-fluorescent in its native state, possesses excellent membrane permeability due to its non-polar property, and the rhodamine dye generated after oxidation diffuses into mitochondria. The excitation wavelength of LHA585 is 561 nm, and its emission wavelength ranges from 570 to 620 nm .
Cat. No.: HY-D3403
CAS No.: 3121511-19-8
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LHA930 is a fluorescent probe for in vivo detection of early-stage ferroptosis. By introducing a 4-phenyl-3-methylbut-2-enyl reactive group responsive to lipid hydrogen abstraction, LHA930 exhibits fluorescence turn-on upon the action of oxidative radicals associated with lipid peroxidation, enabling detection of lipid peroxidation during the early stage of ferroptosis. The detection wavelength of LHA930 is Ex/Em = 860/930 nm. LHA930 can be used for near-infrared fluorescence imaging studies of ferroptosis in APAP-induced mouse liver injury models .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
