Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
antibody-PROTAC conjugate
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "antibody-PROTAC conjugate" in MCE Product Catalog:
Cat. No.: HY-189231
Research Areas:
ARV-771-Azobenzene is an azide-containing PROTAC-Linker conjugate for the construction of PROTAC-antibody conjugates (PACs), consisting of the BRD4 PROTAC ARV-771 (HY-100972) and an azobenzene linker cleavable by azoreductase. ARV-771-Azobenzene acts as a payload for conjugation with DBCO-modified antibodies. Conjugation of ARV-771-Azobenzene with DBCO-modified Sacituzumab generates the azoreductase-cleavable SAC-ARV-771 conjugate (ASA). Conjugation of ARV-771-Azobenzene with DBCO-modified IgG generates IgG-ARV-771. ARV-771-Azobenzene is applicable to studies on hypoxia-responsive antibody-PROTAC conjugates and triple-negative breast cancer .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
