ARV-771-Azobenzene -PEG3-DBCO-PEG4-amide
ARV-771-Azobenzene is an azide-containing PROTAC-Linker conjugate for the construction of PROTAC-antibody conjugates (PACs), consisting of the BRD4 PROTAC ARV-771 (HY-100972) and an azobenzene linker cleavable by azoreductase. ARV-771-Azobenzene acts as a payload for conjugation with DBCO-modified antibodies. Conjugation of ARV-771-Azobenzene with DBCO-modified Sacituzumab generates the azoreductase-cleavable SAC-ARV-771 conjugate (ASA). Conjugation of ARV-771-Azobenzene with DBCO-modified IgG generates IgG-ARV-771. ARV-771-Azobenzene is applicable to studies on hypoxia-responsive antibody-PROTAC conjugates and triple-negative breast cancer.
For research use only. We do not sell to patients.
- Formula: C106H130ClN17O22S2
- Molecular Weight:2093.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
ARV-771-Azobenzene (n-7) reacts in anhydrous dichloromethane in the presence of DMAP and TEA, and is obtained in a 52% yield after purification by HPLC[1].
ARV-771-Azobenzene conjugates with DBCO-modified Sacituzumab of different DAR values to generate the ASA series, and the product obtained from DBCO-Sacituzumab with a DAR of approximately 5 is designated as ASA[1].
ARV-771-Azobenzene is conjugated with DBCO-modified IgG at a DAR of ≈ 5 to generate IgG-ARV-771[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 2093.85
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Formula C106H130ClN17O22S2
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SMILES
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@H](C4=NN=C(N42)C)CC(NCCOCCCOCC(N[C@H](C(N5C[C@@H](C[C@H]5C(N[C@@H](C)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)OC(OCC(C=C8)=CC=C8/N=N/C(C=C9)=CC=C9C(NCCNC(CCOCCOCCOCCN(N=NC%10C%11=C%12C=CC=C%11)C%10C(C=CC=C%13)=C%13CC%12C(CCC(NCCOCCOCCOCCOCCC(O)=O)=O)=O)=O)=O)=O)=O)C(C)(C)C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ARV-771-Azobenzene -PEG3-DBCO-PEG4-amide Related Classifications
HY-189231 Related Classifications
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