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bile alcohol

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By Targets:	G protein-coupled Bile Acid Receptor 1 (2) Endogenous Metabolite (2) FXR (1) GLP Receptor (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1) Metabolic Disease (2)

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Targets Recommended: Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-106539

Colesevelam hydrochloride	FXR G protein-coupled Bile Acid Receptor 1 GLP Receptor	Metabolic Disease Cancer
Colesevelam hydrochloride is an orally active bile acid sequestrant, lipid-lowering agent, and glycemic control agent. Colesevelam hydrochloride binds bile acids in the gastrointestinal tract to form nonabsorbable complexes, interrupts enterohepatic recirculation and increases fecal bile acid elimination. Colesevelam hydrochloride modulates FXR, TGR5, and Cyp7a1 activity and triggers cAMP signaling and GLP-1 release. Colesevelam hydrochloride alters hepatic lipid and glucose metabolism, suppresses hepatic glycogenolysis, reduces hepatic triglyceride and cholesterol levels, and increases LDL-C (low-density lipoprotein cholesterol) clearance. Colesevelam hydrochloride can be used for the research of type 2 diabetes mellitus, hypercholesterolemia, and alcohol-related liver disease .

HY-171949

5β-Cholestane-3α,7α,12α,25-tetrol 3α,7α,12α,25-Tetrahydroxycoprostane	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite	Metabolic Disease
5β-Cholestane-3α,7α,12α,25-tetrol (3α,7α,12α,25-Tetrahydroxycoprostane) is a bile acid alcohol. 5β-Cholestane-3α,7α,12α,25-tetrol is a GPBAR1 (also known as TGR5) activator (EC₅₀: 1.36 μM). 5β-Cholestane-3α,7α,12α,25-tetrol is the predominant bile-alcohol disease marker present in patients with Cerebrotendinous xanthomatosis (CTX) .

HY-N13266

5β-Cholestane-3α,7α,12α,25,27-pentol	Endogenous Metabolite	Inflammation/Immunology
5β-Cholestane-3α,7α,12α,25,27-pentol is a bile alcohol found in amphibian bile. 5β-Cholestane-3α,7α,12α,25,27-pentol serves as a principal or sole constituent of sulfate-conjugated bile salts in gallbladder bile of the caecilian Dermophis mexicanus. 5β-Cholestane-3α,7α,12α,25,27-pentol appears as a minor constituent in bile of the toad Bufo b. formosus. 5β-Cholestane-3α,7α,12α,25,27-pentol may represent the end product of cholesterol metabolism in the caecilian, as bile acids remain undetected in this organism .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N13266

5β-Cholestane-3α,7α,12α,25,27-pentol	Structural Classification Natural Products Animals Steroids Source Classification	Endogenous Metabolite
5β-Cholestane-3α,7α,12α,25,27-pentol is a bile alcohol found in amphibian bile. 5β-Cholestane-3α,7α,12α,25,27-pentol serves as a principal or sole constituent of sulfate-conjugated bile salts in gallbladder bile of the caecilian Dermophis mexicanus. 5β-Cholestane-3α,7α,12α,25,27-pentol appears as a minor constituent in bile of the toad Bufo b. formosus. 5β-Cholestane-3α,7α,12α,25,27-pentol may represent the end product of cholesterol metabolism in the caecilian, as bile acids remain undetected in this organism .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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bile alcohol

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