5β-Cholestane-3α,7α,12α,25-tetrol
5β-Cholestane-3α,7α,12α,25-tetrol (3α,7α,12α,25-Tetrahydroxycoprostane) is a bile acid alcohol. 5β-Cholestane-3α,7α,12α,25-tetrol is a GPBAR1 (also known as TGR5) activator (EC50: 1.36 μM). 5β-Cholestane-3α,7α,12α,25-tetrol is the predominant bile-alcohol disease marker present in patients with Cerebrotendinous xanthomatosis (CTX).
For research use only. We do not sell to patients.
- CAS No.: 18866-87-0
- Formula: C27H48O4
- Molecular Weight:436.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
Description
Chemical Information
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CAS No. 18866-87-0
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Molecular Weight 436.67
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Formula C27H48O4
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SMILES
O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCCC(C)(O)C)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C
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Synonyms
3α,7α,12α,25-Tetrahydroxycoprostane
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Iguchi Y, et al. Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor. J Lipid Res. 2010 Jun;51(6):1432-41. [Content Brief]
[2]. DeBarber AE, et al. Newborn screening for cerebrotendinous xanthomatosis is the solution for early identification and treatment. J Lipid Res. 2018 Nov;59(11):2214-2222. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5β-Cholestane-3α,7α,12α,25-tetrol Related Classifications
HY-171949 Related Classifications
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