![[Glp5,(Me)Phe8,Sar9] Substance P (5-11)](https://file.medchemexpress.com/product_pic/hy-p3801.gif "Click to View [Glp5,(Me)Phe8,Sar9] Substance P (5-11) Product Detail")
![[DAla4] Substance P (4-11)](https://file.medchemexpress.com/product_pic/hy-p3883.gif "Click to View [DAla4] Substance P (4-11) Product Detail")
Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
51 Results for "
brain cortex
" in MedChemExpress (MCE) Product Catalog:
Products (51)
51 Results for "brain cortex" in MCE Product Catalog:
3
3 Cited Publications
Art. -Nr.: HY-17416
CAS. Nr.: 29110-48-3
Target:
Forschungsgebiete:
Cardiovascular Disease Infection Neurological Disease Metabolic Disease
Guanfacine hydrochloride is an orally active and blood-brain barrier permeability noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD) .
2
2 Cited Publications
Art. -Nr.: HY-13225B
Reinheit: ≥95.0%
Synonyms: RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate
Target:
Forschungsgebiete:
Rivanicline (RJR-2403) hemioxalate is a neuronal nicotinic receptor agonist. Rivanicline hemioxalate is highly selective for the rat brain cortex nAChRs (Ki = 26 nM, EC50 of 732 nM) and α4β2 subtype (Ki = 26 nM, EC50 = 16 μM). Rivanicline hemioxalate can significantly restore the learning impairment and cognitive dysfunction. Rivanicline hemioxalate can be used for the study of neurodegenerative diseases (such as schizophrenia or Alzheimer's disease) .
1
1 Cited Publications
Art. -Nr.: HY-W013215
CAS. Nr.: 28874-58-0
Synonyms: cis-7,10,13,16-Docosatetraenoic acid
Category:
Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
1
Forschungsgebiete:
Rapastinel (GLYX-13) is a potent NMDAR modulator capable of crossing the blood-brain barrier, and it exhibits extremely high affinity for human NMDAR (EC50=0.0017-9.9 nM). Rapastinel enhances ERK signaling and activates the mTOR pathway, thereby upregulating the expression of BDNF and VGF, and inducing significant neuroplastic changes such as enhanced LTP and increased mature dendritic spine density in the hippocampus. Rapastinel moderately elevates the efflux of dopamine, norepinephrine and 5-HT in the prefrontal cortex, and uniquely avoids side effects of traditional antidepressants such as dissociation, addiction or sedation. Rapastinel is applicable to the research of major depressive disorder and hepatocellular carcinoma .
1
1 Cited Publications
Art. -Nr.: HY-N2411
CAS. Nr.: 60314-89-8
Category:
Uncaria rhynchophylla (Miq.) Miq. ex Havil. Extract Alkaloids Plant Indole Alkaloids Rubiaceae Extract
Target:
1
Forschungsgebiete:
Rapastinel (GLYX-13) Trifluoroacetate is a potent NMDAR modulator capable of crossing the blood-brain barrier, and it exhibits extremely high affinity for human NMDAR (EC50=0.0017-9.9 nM). Rapastinel Trifluoroacetate enhances ERK signaling and activates the mTOR pathway, thereby upregulating the expression of BDNF and VGF, and inducing significant neuroplastic changes such as enhanced LTP and increased mature dendritic spine density in the hippocampus. Rapastinel Trifluoroacetate moderately elevates the efflux of dopamine, norepinephrine and 5-HT in the prefrontal cortex, and uniquely avoids side effects of traditional antidepressants such as dissociation, addiction or sedation. Rapastinel Trifluoroacetate is applicable to the research of major depressive disorder and hepatocellular carcinoma .
Synonyms: DHA (Standard); Cervonic acid (Standard); Doconexent (Standard)
Art. -Nr.: HY-N0506
CAS. Nr.: 84954-93-8
Category:
Rhodiola rosea Linn. Extract Plant Simple Phenylpropanols Crassulaceae Extract Phenylpropanoids
Target:
Target:
Forschungsgebiete:
Gallamine Triethiodide is a blood-brain barrier-permeable skeletal muscle relaxant. Gallamine Triethiodide induces skeletal muscle paralysis by blocking acetylcholine. Gallamine Triethiodide directly stimulates intracardiac β receptors. Gallamine Triethiodide prolongs the duration of afterdischarge in the cat cerebral cortex. Gallamine Triethiodide can be used in studies related to convulsive disorders .
Art. -Nr.: HY-P6292
CAS. Nr.: 2724212-01-3
Forschungsgebiete:
Target:
Synonyms: BAY x 3702
Target:
Forschungsgebiete:
Repinotan hydrochloride (BAY x 3702) is a potent, selective, brain-penetrant and orally active 5-HT1A receptor agonist, with Ki values of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex), and 0.59 nM (rat hippocampus Repinotan hydrochloride has a weak affinity for other related receptors. Repinotan hydrochloride has pronounced neuroprotective effects .
Art. -Nr.: HY-W795507
CAS. Nr.: 69906-85-0
Target:
Forschungsgebiete:
Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and 5-HT1B receptor (Ki: 2.1 and 3 nM respectively) .
Art. -Nr.: HY-P3801
CAS. Nr.: 77128-69-9
Synonyms: DiMe-C7
Target:
Forschungsgebiete:
Art. -Nr.: HY-123858
CAS. Nr.: 2002495-17-0
Target:
Forschungsgebiete:
VU6001221 is a blood-brain barrier permeable Choline Transporter (CHT) inhibitor (IC50 = 270 nM). VU6001221 increases the likelihood of extracellular choline elevation activating synaptic α7 nicotine ACh receptors. VU6001221 attenuates potassium-induced ACh levels in the prefrontal cortex .
Art. -Nr.: HY-P3883
CAS. Nr.: 81381-50-2
Target:
Forschungsgebiete:
Art. -Nr.: HY-13225A
CAS. Nr.: 15585-43-0
Synonyms: RJR-2403; (E)-Metanicotine
Target:
Forschungsgebiete:
Rivanicline (RJR-2403) is a neuronal nicotinic receptor agonist. Rivanicline is highly selective for the rat brain cortex nAChRs (Ki = 26 nM, EC50 of 732 nM) and α4β2 subtype (Ki = 26 nM, EC50 = 16 μM). Rivanicline can significantly restore the learning impairment and cognitive dysfunction. Rivanicline can be used for the study of neurodegenerative diseases (such as schizophrenia or Alzheimer's disease) .
Art. -Nr.: HY-102043
CAS. Nr.: 2095312-08-4
Target:
Forschungsgebiete:
PDM-631 is a selective and orally active PDE2A inhibitor with blood-brain barrier penetration. PDM-631 exhibits potent inhibitory activity against human and rat recombinant PDE2A with IC50 values of 1.5 nM and 4.2 nM, respectively. PDM-631 increases cGMP levels in the rat cerebral cortex. PDM-631 can be used for the study of schizophrenia and neurodegenerative disorders .
Art. -Nr.: HY-120004
CAS. Nr.: 2115022-67-6
Target:
Forschungsgebiete:
PF-06827443 is an orally active M1 receptor positive allosteric modulator with an EC50 of 47 nM and a Ki of 16 nM, and a PDE11A4 inhibitor with an IC50 of 5.06 μM. PF-06827443 enhances the effects of acetylcholine. PF-06827443 crosses the blood-brain barrier, induces LTD in the prefrontal cortex, increases sEPSC frequency in layer V pyramidal cells, and increases striatal inositol monophosphate accumulation. PF-06827443 induces convulsions, impairs cognition, reduces stimulant-evoked locomotion, reverses Scopolamine (HY-N0296)-induced learning/memory deficits, and causes cholinergic adverse events and convulsions in rats and dogs. PF-06827443 can be used for research on schizophrenia and Alzheimer's disease .
Art. -Nr.: HY-N0506R
CAS. Nr.: 84954-93-8
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
