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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
brefeldin A
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "brefeldin A" in MCE Product Catalog:
170
Category:
Infection Microorganisms Macrolide Antibiotics Antibiotics Antiviral Disease Research Anticancer Disease Research Fields
Target:
Cat. No.: HY-16592R
CAS No.: 20350-15-6
Synonyms: BFA (Standard); Cyanein (Standard); Decumbin (Standard)
Cat. No.: HY-151461
CAS No.: 2756173-91-6
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CHNQD-01255 is an orally active Arf-GEFs inhibitor with potent anti-hepatocellular carcinoma (HCC) efficacy .
Cat. No.: HY-177269
CAS No.: 2648988-92-3
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CHNQD-01269, a brefeldin A-cinnamate derivative, is an Arf1 inhibitor. CHNQD-01269 exhibits potent cytotoxic activity against HepG2 and BEL-7402 cells, with IC50 values of 0.29 and 0.84 μM, respectively. CHNQD-01269 is indicated for hepatocellular carcinoma (HCC) research .
Cat. No.: HY-177270
CAS No.: 2762488-97-9
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CHNQD-01281, a derivative of Brefeldin A (HY-16592), is a EGFR modulator. CHNQD-01281 has strong antiproliferative activities against cancer cells (IC50: 0.079 and 0.081 μM for T24 and J82 cells, respectively). CHNQD-01281 regulates both EGFR/PI3K/AKT and EGFR/ERK pathways and mediates the chemotactic effect of chemokines on immune effector cells. CHNQD-01281 remarkably inhibits tumor growth in T24 xenograft mice model and prolongs the survival time in MB49 allogeneic mice model via inducing infiltration of cytotoxic T cells .
Cat. No.: HY-173280
CAS No.: 3035018-34-6
Synonyms: CHNQD-01228
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Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins. The IC50 value for the proliferation of T24 cells is 0.22 μM. It can also dose-dependently inhibit the migration and colony formation of T24 cells, induce G1 phase arrest and trigger Apoptosis. Brefeldin A 4-O-nicotinate exerts its anti-cancer activity by targeting the BMX protein to inhibit the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, as well as by inhibiting the Arf1 protein to eliminate bladder cancer stem cells and activate anti-tumor immunity. Brefeldin A 4-O-nicotinate can be used in the research related to bladder cancer .
Cat. No.: HY-P2674
CAS No.: 113516-56-6
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Cat. No.: HY-D3107
CAS No.: 1826900-73-5
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ER-Fluidity is a fluorescent probe used to detect the membrane fluidity of the endoplasmic reticulum (ER). ER-Fluidity consists of BODIPY, Coumarin (HY-N0709) moieties and a long-chain n-octadecyl group (n-C18). The excitation/emission wavelengths of the Coumarin moiety of ER-Fluidity are Ex/Em = 350/439 nm, while those of the BODIPY moiety are Ex/Em = 500/518 nm. In cell experiments, 488 nm is additionally used as an excitation wavelength for the BODIPY moiety .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
