3035018-34-6
Chemical Structure
Brefeldin A 4-O-nicotinate
Synonym(s): CHNQD-01228
- CAS No.: 3035018-34-6
- Formula:C22H27NO5
- Molecular Weight:385.45
InChIKey: PZBDYXBKLPZPJH-ZWADFAHBSA-N
SMILES: O=C1O[C@@H](C)CCC/C=C/[C@@]2([H])[C@](C[C@@H](O)C2)([H])[C@H](OC(C3=CN=CC=C3)=O)/C=C/1
Biological Activity: Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins. The IC50 value for the proliferation of T24 cells is 0.22 μM. It can also dose-dependently inhibit the migration and colony formation of T24 cells, induce G1 phase arrest and trigger Apoptosis. Brefeldin A 4-O-nicotinate exerts its anti-cancer activity by targeting the BMX protein to inhibit the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, as well as by inhibiting the Arf1 protein to eliminate bladder cancer stem cells and activate anti-tumor immunity. Brefeldin A 4-O-nicotinate can be used in the research related to bladder cancer[1].
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Brefeldin A 4-O-nicotinate | Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins. The IC50 value for the proliferation of T24 cells is 0.22 μM. It can also dose-dependently inhibit the migration and colony formation of T24 cells, induce G1 phase arrest and trigger Apoptosis. Brefeldin A 4-O-nicotinate exerts its anti-cancer activity by targeting the BMX protein to inhibit the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, as well as by inhibiting the Arf1 protein to eliminate bladder cancer stem cells and activate anti-tumor immunity. Brefeldin A 4-O-nicotinate can be used in the research related to bladder cancer. | |||||||||||||||||||||
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