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Cat. No.: HY-P2674

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KDEL

KDEL is a tetrapeptide serving as an endoplasmic reticulum (ER) retrieval/retention signal. KDEL can target and deliver exogenous antigen peptides to the ER, significantly enhance and prolong MHC class I molecule presentation, and effectively boost anti-tumor immune responses.

For research use only. We do not sell to patients.

CAS No.: 113516-56-6
Formula: C₂₁H₃₇N₅O₉
Molecular Weight:503.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

KDEL Chemical Structure

CAS No.: 113516-56-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All MHC Isoforms :

MHC I
MHC II

In Vitro

KDEL (10 μM; 30 min-10 h) fused to the C-terminus of OVA_257-264 enhances MHC class I-associated peptide presentation on EL-4 and RMA cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KDEL (10 μM; subcutaneous injection after DC loading; twice) significantly enhances and prolongs MHC class I presentation of exogenous peptides in C57BL/6 mice, induces a stronger specific CTL response, and significantly inhibits E.G7‑OVA tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice (6-8 weeks old) with E.G7‑OVA tumor challenge^[1]
Dosage:

10 μM OVA_257‑264‑KDEL peptide
Administration:

subcutaneous injection ( days 0 and 7)
Result:

Induced greatly enhanced specific CD8⁺ cytotoxic T lymphocyte (CTL) responses, remarkably prolonged surface MHC class I/peptide complex display, and resulted in significant inhibition of E.G7‑OVA tumor growth in vivo compared with OVA_257‑264 or OVA_257‑264‑TEWT peptide groups.

Chemical Information

CAS No. 113516-56-6
Molecular Weight 503.55
Formula C₂₁H₃₇N₅O₉
Sequence

Lys-Asp-Glu-Leu
Sequence Shortening

KDEL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang L, et al. MHC class I-associated presentation of exogenous peptides is not only enhanced but also prolonged by linking with a C-terminal Lys-Asp-Glu-Leu endoplasmic reticulum retrieval signal. Eur J Immunol. 2004;34(12):3582-3594. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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