2. Immunology/Inflammation
  3. MHC
  4. KDEL

KDEL is a tetrapeptide serving as an endoplasmic reticulum (ER) retrieval/retention signal. KDEL can target and deliver exogenous antigen peptides to the ER, significantly enhance and prolong MHC class I molecule presentation, and effectively boost anti-tumor immune responses.

For research use only. We do not sell to patients.

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KDEL

KDEL Chemical Structure

CAS No. : 113516-56-6

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KDEL Related Antibodies

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Description

KDEL is a tetrapeptide serving as an endoplasmic reticulum (ER) retrieval/retention signal. KDEL can target and deliver exogenous antigen peptides to the ER, significantly enhance and prolong MHC class I molecule presentation, and effectively boost anti-tumor immune responses[1].

In Vitro

KDEL (10 μM; 30 min-10 h) fused to the C-terminus of OVA257-264 enhances MHC class I-associated peptide presentation on EL-4 and RMA cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KDEL Related Antibodies
In Vivo

KDEL (10 μM; subcutaneous injection after DC loading; twice) significantly enhances and prolongs MHC class I presentation of exogenous peptides in C57BL/6 mice, induces a stronger specific CTL response, and significantly inhibits E.G7‑OVA tumor growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (6-8 weeks old) with E.G7‑OVA tumor challenge[1]
Dosage: 10 μM OVA257‑264‑KDEL peptide
Administration: subcutaneous injection ( days 0 and 7)
Result: Induced greatly enhanced specific CD8+ cytotoxic T lymphocyte (CTL) responses, remarkably prolonged surface MHC class I/peptide complex display, and resulted in significant inhibition of E.G7‑OVA tumor growth in vivo compared with OVA257‑264 or OVA257‑264‑TEWT peptide groups.
Molecular Weight

503.55

Formula

C21H37N5O9
CAS No.
Sequence

Lys-Asp-Glu-Leu
Sequence Shortening

KDEL
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KDEL Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KDEL113516-56-6MHCMajor Histocompatibility Complexdendritic cellsERMHC class IproteasomeGolgiEL-4 cellsKDEL receptorTAPantigen-presenting cellsbrefeldin AInhibitorinhibitorinhibit

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