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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
californicum
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "californicum" in MCE Product Catalog:
3
Category:
Liliaceae Other Diseases Veratrum californicum Durand Plants Disease Research Fields Steroids
Target:
Cat. No.: HY-N12891
CAS No.: 75539-65-0
Category:
Target:
Cat. No.: HY-N0836A
CAS No.: 60326-37-6
Synonyms: 11-Ketocyclopamine hydriodide
Target:
Hedgehog Wnt Akt mTOR AMPK DNA/RNA Synthesis Apoptosis Autophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism
Research Areas:
Jervine hydriodide (11-Ketocyclopamine hydriodide) is an orally active steroidal alkaloid and Hedgehog signaling pathway inhibitor. Jervine hydriodide can be isolated from Veratrum californicum. Jervine hydriodide regulates Wnt, inhibits the AKT/mTOR signaling pathway, and activates the AMPK signaling pathway. Jervine hydriodide induces DNA damage, Apoptosis, Autophagy, ROS production and Mitochondrial damage. Jervine hydriodide exhibits anti-cancer and anti-inflammatory activities. Jervine hydriodide reduces tumor growth rate and weight in xenograft models. Jervine hydriodide can be used in studies related to triple-negative breast cancer, nasopharyngeal carcinoma and non-small cell lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
