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By Targets:	Aminotransferases (Transaminases) (1) Amylases (3) Antifolate (2) Apoptosis (1) Biochemical Assay Reagents (69) Deubiquitinase (1) DNA/RNA Synthesis (9) Drug Derivative (1) Drug Isomer (1) Drug Metabolite (1) Endogenous Metabolite (7) Endonuclease (7) Environmental Pollutants (2) Fluorescent Dye (1) Fructose-1,6-bisphosphate aldolase (1) Glycosidase (2) Guanylate Cyclase (1) Herbicide (1) IKK (1) Integrin (1) Isotope-Labeled Compounds (1) Lipase (6) NF-κB (1) PI3K (1) PKC (1) Reference Standards (1) Thrombin (1)
By Research Areas:	Cancer (14) Endocrinology (6) Inflammation/Immunology (7) Metabolic Disease (26)
Oligonucleotides:	Aptamers (1)

113

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Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1923

L-Asparaginase 10+ Cited Publications L-ASNase	Apoptosis DNA/RNA Synthesis	Cancer
L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis .

HY-B1335

Pentetic acid 3 Publications Verification Diethylenetriaminepentaacetic acid; DTPA	Environmental Pollutants Biochemical Assay Reagents	Others
Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide .

HY-B2193

α-Amylase 2 Publications Verification	Environmental Pollutants Amylases	Others
α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.

HY-P2996

NAD(P)H-Nitrate reductase 1 Publications Verification	Others	Others
NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants, the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .

HY-112134

CSN5i-3 Maximum Cited Publications 23 Publications Verification	Deubiquitinase	Cancer
CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC₅₀ value of 5.8 nM .

HY-14518

Aminopterin 4-Aminofolic acid; APGA	Antifolate	Inflammation/Immunology Cancer
Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a K_i of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia .

HY-B2192

Amylase	Amylases	Metabolic Disease Cancer
Amylase is an enzyme produced by pancreas and salivary glands, catalyzing the hydrolysis of starch into sugars. Amylase are broadly classified into α, β, and γ subtypes .

HY-W040256

Acid phosphatase, wheat ACP	Endogenous Metabolite	Metabolic Disease Cancer
Acid phosphatase, wheat (ACP) is a hydrolase enzyme found in wheat. Acid phosphatase, wheat catalyses the hydrolysis of orthophosphate monoesters under acidic conditions .

HY-P2968

Bacterial α-Amylase	Amylases	Others
Bacterial α-Amylase catalyses the hydrolysis of internal α-1,4-glycosidic linkages in starch in low molecular weight products, such glucose, maltose and maltotriose units. Bacterial α-Amylase is often used in biochemical studies .

HY-B2193A

α-Amylase, Human Saliva 1,4-alpha-D-Glucan-glucanohydrolase, ptyalin	Biochemical Assay Reagents	Metabolic Disease Inflammation/Immunology
α-Amylase, Human Saliva (1,4-alpha-D-Glucan-glucanohydrolase) is a hydrolase enzyme that can be isolated from human saliva. α-Amylase, Human Saliva catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose. α-Amylase, Human Saliva can be used in life science research .

HY-B2193C

α-Amylase, Porcine Pancreatic 1,4-alpha-D-Glucan-glucanohydrolase, amy2, PPA, PA	Biochemical Assay Reagents	Others
α-Amylase, Porcine Pancreatic (1,4-alpha-D-Glucan-glucanohydrolase) is a hydrolase enzyme that can be isolated from porcine pancreatic. α-Amylase, Porcine Pancreatic catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose. α-Amylase, Porcine Pancreatic can be used in life science research .

HY-E70015

Phosphoenolpyruvate carboxylase, Microorganism PEPC	Others	Others
Phosphoenolpyruvate carboxylase, Microorganism (PEPC) is a carbon dioxide fixing enzyme that in an irreversible manner and in the presence of Mg ²⁺, converts phosphoenolpyruvate and bicarbonate into oxaloacetate and inorganic phosphorus. Phosphoenolpyruvate carboxylase catalyses the primary assimilation of CO(2) in Crassulacean acid metabolism plants. Phosphoenolpyruvate carboxylase plays a major role in setting the day-night pattern of metabolism in plants .

HY-B2193B

α-Amylase, Human Pancreas Amylase, a-Amylase, 1,4-a-D-glucan glucanohydrolase, glycogenase	Biochemical Assay Reagents	Others
α-Amylase, Human Pancreas (Amylase) is a hydrolase enzyme that can be isolated from human pancreas. α-Amylase, Human Pancreas catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose. α-Amylase, Human Pancreas can be used in life science research .

HY-P2796

Pyruvate decarboxylase PDC	Biochemical Assay Reagents	Metabolic Disease
Pyruvate decarboxylase (PDC) is an enzyme that catalyses the decarboxylation of pyruvic acid to acetaldehyde. Pyruvate decarboxylase catalyses the non-oxidative conversion of pyruvate (or other 2-oxo acids) to acetaldehyde and CO₂ .

HY-E70398

Sorbitol dehydrogenase L-Iditol dehydrogenase; Polyol dehydrogenase; SDH	Biochemical Assay Reagents	Metabolic Disease
Sorbitol dehydrogenase (L-Iditol dehydrogenase) is an oxidoreductasea and catalyses the conversion of sorbitol to fructose with NAD ⁺ as the coenzyme. Sorbitol dehydrogenase catalyses pH-dependent redox reactions between NAD ⁺/NADH and sorbitol/fructose. Sorbitol dehydrogenase is implicated in diabetic complications and is a biomarker of drug-induced liver injury. Sorbitol dehydrogenase can be used for the research of diabetes and liver injury .

HY-P2958

Choloylglycine hydrolase	Biochemical Assay Reagents	Metabolic Disease
Choloylglycine hydrolase is a conjugated bile salt hydrolase that catalyses the hydrolysis of amide bond in conjugated bile acids. Choloylglycine hydrolase is expressed by intestinal microbiota. Choloylglycine hydrolase can be studied in research on type 2 diabetes .

HY-P2892

Fumarase	Endogenous Metabolite	Metabolic Disease
Fumarase catalyses the conversion of l-malic acid to fumaric acid. Fumarase participates in the tricarboxylic acid cycle in mitochondria. Fumarase participates in the cellular response to DNA double strand breaks .

HY-E70016

Terminal deoxyribonucleotidyltransferase TdT	DNA/RNA Synthesis	Others Cancer
Terminal deoxyribonucleotidyltransferase (TdT) catalyses the condensation of deoxyribonucleotide triphosphates onto the 3' hydroxyl ends of DNA strands and adds N-regions to gene segment junctions during V(D)J recombination. Terminal deoxyribonucleotidyltransferase is expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells .

HY-W013557

3-Hydroxyxanthone 3-Hydroxy-xanthen-9-one	Integrin	Inflammation/Immunology
3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one) is a xanthone compound, with . 3-Hydroxyxanthone inhibits NADPH-catalysed lipid peroxidation in human umbilical vein endothelial cells (HUVECs). 3-Hydroxyxanthone also inhibits TNF-alpha induced ICAM-1 expression .

HY-E70039

alpha-2-3,6,8-Sialidosidase (SpNanA)	Others	Others
alpha-2-3,6,8-Sialidosidase (SpNanA) catalyses hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates .

HY-P2723

Dextran sucrase	Endogenous Metabolite	Metabolic Disease
Dextran sucrase is an extracellular glucosyltransferase (GTF) that catalyses the transfer of D-glucopyranosyl residues from sucrose to dextran .

HY-E70010

Aldose 1-epimerase mutarotases	Endogenous Metabolite	Others
Aldose 1-epimerase (mutarotases) is a key enzyme of carbohydrate metabolism catalysing the interconversion of the α- and β-anomers of hexose sugars such as glucose and galactose. Aldose 1-epimerase is essential for normal carbohydrate metabolism and the production of complex oligosaccharides .

HY-P2996A

Nitrate Reductase, Arabidopsis thaliana	Drug Isomer	Others
Nitrate Reductase, Arabidopsis thaliana is the isomer of NAD(P)H-Nitrate reductase (HY-P2996). NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants，the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .

HY-N11409A

Shikimate-3-phosphate lithium	Herbicide	Others
Shikimate-3-phosphate lithium is the salt form of Shikimate-3-phosphate. Shikimate-3-phosphate lithium is a central microbial, parasite and plant metabolite, as a product of the shikimate kinase-catalysed reaction. Shikimate-3-phosphate lithium serves as an enzyme substrate for 5-enolpyruvoyl-shikimate 3-phosphate synthase, which is a target of anti-infectives and of herbicides .

HY-P2865

Guanylate kinase	Guanylate Cyclase	Metabolic Disease
Guanylate kinase is a central enzyme in the guanine salvage pathway. Guanylate kinase catalyses the reversible Mg ²⁺-dependent transfer of the terminal phosphoryl group from ATP to GMP, or dGMP .

HY-P3175

Phosphogluconate dehydrogenase (NADP, decarboxylating) 6-Phosphogluconate dehydrogenase	Biochemical Assay Reagents	Metabolic Disease
Phosphogluconate dehydrogenase (NADP, decarboxylating) (6-Phosphogluconate dehydrogenase) is an oxidative carboxylase that catalyses the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate in the context of the oxidative part of the pentose phosphate pathway .

HY-P2742A

L-Ascorbate oxidase, Cucumber	Endogenous Metabolite	Metabolic Disease
L-Ascorbate oxidase, Cucumber belongs to the family of oxidoreductases acting on diphenols and related substances as donor with oxygen as acceptor. L-Ascorbate oxidase, Cucumber catalyses the oxidation of L‐Ascorbate (HY-B0166) with oxygen to dehydroascorbate with the generation of water. L-Ascorbate oxidase, Cucumber can be used in baking processes and cereal‐based processes .

HY-177804

Thrombin aptamer sodium	Thrombin	Inflammation/Immunology
Thrombin aptamer is a 11mer-DNA aptamer that targets thrombin. Thrombin aptamer inhibites thrombin-catalysed fibrin-clot formation in vitro

HY-148051

Ilaprazole sulfone	Drug Metabolite	Inflammation/Immunology Cancer
Ilaprazole sulfone is the major metabolite of Ilaprazole (HY-101664), is predominantly catalysed by CYP3A4/5. Ilaprazole (IY-81149) is an orally active proton pump inhibitor .

HY-P3764

Protein kinase C substrate	PKC	Others
Protein kinase C substrate is a substrate of Protein kinase C, can be used to detect protein. Protein kinase C is a key regulatory element in signal transduction and exerts its effects by catalysing specific substrate phosphorylation .

HY-14518R

Aminopterin (Standard) 4-Aminofolic acid (Standard); APGA (Standard)	Reference Standards Antifolate	Inflammation/Immunology Cancer
Aminopterin (Standard) is the analytical standard of Aminopterin. This product is intended for research and analytical applications. Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia .

HY-P2744

Ribulose bisphosphate carboxylase Ribulose 1,5-bisphosphate carboxylase	Biochemical Assay Reagents	Others
Ribulose bisphosphate carboxylase (Ribulose 1,5-bisphosphate carboxylase) catalyses the carboxylation (CO₂ addition) or oxygenation (O₂ addition) of d-ribulose-1,5-bisphosphate (RuBP) and the subsequent carbon–carbon cleavage to form two molecules of 3-phospho-d-glycerate (PGA) (with CO₂) or one molecule of PGA and one molecule of 2-phospho-glycolate (PG; with O₂) .

HY-E70033

D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP)	Endogenous Metabolite	Metabolic Disease
D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) is a member of CAZy glycoside hydrolase GH112 family, is often used in biochemical studies. D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) catalyses the phosphorolysis of lacto-n-biose and galacto-n-biose, to produce Gal-1-P and the corresponding N-acetyl-D-hexosamine .

HY-W749825

Pentetic acid-13C5 Diethylenetriaminepentaacetic acid-¹³C₅; DTPA-¹³C₅	Isotope-Labeled Compounds Fluorescent Dye	Others
Pentetic acid- ¹³C₅ (Diethylenetriaminepentaacetic acid- ¹³C₅) is the ¹³C-labeled Pentetic acid (HY-B1335). Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide .

HY-E71005

Mucopolysaccharidase, Bovine	Endogenous Metabolite	Metabolic Disease
Mucopolysaccharidase, Bovine catalyses the hydrolysis of a mucopolysaccharide.

HY-E71138

(S,S)-Butanediol dehydrogenase	Biochemical Assay Reagents	Others
(S,S)-Butanediol dehydrogenase (EC 1.1.1.76) catalyses the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol. It can also catalyse the irreversible reduction of diacetyl to (S)-acetoin.

HY-E71256

β-(isoxazolin-5-on-4-yl)-L-Alanine synthase	Biochemical Assay Reagents	Others
β-(isoxazolin-5-on-4-yl)-L-Alanine synthase (EC 2.5.1.119) catalyse EC 2.5.1.118 (β-(isoxazolin-5-on-2-yl)-L-alanine synthase) also catalyse this reaction in vitro, but not in vivo.

HY-E70916

Pectin acetylesterase, Clostridium thermocellum	Biochemical Assay Reagents	Metabolic Disease
Pectin acetylesterase, Clostridium thermocellum (EC 3.1.1.-) catalyses the hydrolysis of acetate from acetylated pectins.

HY-E71254

α-Xylosidase 31A, Bacteroides ovatus	Biochemical Assay Reagents	Others
α-Xylosidase 31A, Bacteroides ovatus (EC 3.2.1.177) is an enzyme. This enzyme catalyses the following chemical reaction: Hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose. The enzyme catalyses hydrolysis of a terminal, unsubstituted xyloside at the extreme reducing end of a xylogluco-oligosaccharide.

HY-E71120

(S)-Hydroxynitrile lyase	Biochemical Assay Reagents	Others
(S)-Hydroxynitrile lyase (EC 4.1.2.47) catalyses the the cleavage of hydroxynitriles into cyanide and the corresponding aldehyde or ketone.

HY-E71117

(S)-Cheilanthifoline synthase	Biochemical Assay Reagents	Others
(S)-Cheilanthifoline synthase (EC 1.14.21.2) catalysing an oxidative reaction that does not incorporate oxygen into the product.

HY-E71118

(S)-Citramalyl-CoA lyase	Biochemical Assay Reagents	Others
(S)-cheilanthifoline synthase (EC 1.14.21.2) catalysing an oxidative reaction that does not incorporate oxygen into the product.

HY-E71200B

16S rRNA (cytidine1402-2'-O)-Methyltransferase	Biochemical Assay Reagents	Others
16S rRNA (cytidine1402-2'-O)-Methyltransferase (EC 2.1.1.198) catalyses the 2'-O-methylation of cytidine1402 and RsmH (EC 2.1.1.199) catalyses the N4-methylation of cytidine1402 in 16S rRNA. Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.

HY-E71217

α-Amino-acid esterase	Biochemical Assay Reagents	Others
α-Amino-acid esterase (EC 3.1.1.43) catalyses α-Aminoacyl transfer to a number of amine nucleophiles.

HY-E71200D

16S rRNA (cytosine1402-N4)-Methyltransferase	Biochemical Assay Reagents	Others
16S rRNA (cytosine1402-N4)-Methyltransferase (EC 2.1.1.199) catalyses the N4-methylation of cytosine1402 andRsmI (EC 2.1.1.198) catalyses the 2'-O-methylation of cytosine1402 in 16S rRNA. Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.

HY-Y1422T

Lipase, Porcine	Lipase	Metabolic Disease
Lipase, Porcine (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

HY-Y1422P

Lipase, Rhizopus oryzae	Lipase	Metabolic Disease
Lipase, Rhizopus oryzae (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

HY-Y1422Q

Lipase, Rhizopus niveus	Lipase	Metabolic Disease
Lipase, Rhizopus niveus (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

HY-Y1422O

Lipase, Thermus flavus	Lipase	Metabolic Disease
Lipase, Thermus flavus (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

HY-Y1422N

Lipase, Thermus thermophilus	Lipase	Metabolic Disease
Lipase, Thermus thermophilus (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

Cat. No.	Product Name	Target	Research Area

HY-P3764

Protein kinase C substrate	PKC	Others
Protein kinase C substrate is a substrate of Protein kinase C, can be used to detect protein. Protein kinase C is a key regulatory element in signal transduction and exerts its effects by catalysing specific substrate phosphorylation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2193

α-Amylase 2 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Environmental Pollutants Amylases
α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.

HY-B2192

Amylase	Natural Products Microorganisms other families Animals Classification of Application Fields Metabolic Disease Plants Disease Research Fields Source Classification	Amylases
Amylase is an enzyme produced by pancreas and salivary glands, catalyzing the hydrolysis of starch into sugars. Amylase are broadly classified into α, β, and γ subtypes .

HY-W040256

Acid phosphatase, wheat ACP	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Acid phosphatase, wheat (ACP) is a hydrolase enzyme found in wheat. Acid phosphatase, wheat catalyses the hydrolysis of orthophosphate monoesters under acidic conditions .

HY-E70010

Aldose 1-epimerase mutarotases	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Aldose 1-epimerase (mutarotases) is a key enzyme of carbohydrate metabolism catalysing the interconversion of the α- and β-anomers of hexose sugars such as glucose and galactose. Aldose 1-epimerase is essential for normal carbohydrate metabolism and the production of complex oligosaccharides .

HY-N10768

1-Dehydro-[10]-gingerdione	Monophenols Phenols Plants Source Classification Zingiberaceae	IKK NF-κB
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

Cat. No.	Product Name	Chemical Structure

HY-W749825

Pentetic acid-13C5

Pentetic acid- ¹³C₅ (Diethylenetriaminepentaacetic acid- ¹³C₅) is the ¹³C-labeled Pentetic acid (HY-B1335). Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide .

Cat. No.	Product Name		Classification

HY-177804

Thrombin aptamer sodium		Aptamers
Thrombin aptamer is a 11mer-DNA aptamer that targets thrombin. Thrombin aptamer inhibites thrombin-catalysed fibrin-clot formation in vitro

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