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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
cellular environment
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "cellular environment" in MCE Product Catalog:
26
Category:
Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Microorganism Endogenous metabolite
Target:
1
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .
Research Areas:
Collagen (bovine skin) is a three-dimensional cell culture matrix and morphoregulator extracted from bovine skin, which binds to integrins (such as α1β1, α2β1, α11β1) and discoidin domain receptors (DDR1 and DDR2). Collagen (bovine skin) can be reconstituted into a three-dimensional fibrous network to mimic the in vivo tissue environment. It can not only be modified through cross-linking or concentration adjustment, but also interact with fibronectin to enhance matrix-associated cellular activities. Collagen (bovine skin) mediates the proliferation, aggregation, durotactic migration and differentiation of fibroblasts, regulates the synthesis, remodeling and contraction of extracellular matrix, and modulates the expression, activation of MMP as well as cell apoptosis, etc. Collagen (bovine skin) can be used in studies related to the mechanisms of cancer occurrence and development .
Cat. No.: HY-D1190
CAS No.: 198696-03-6
Cat. No.: HY-P5372A
Research Areas:
Cat. No.: HY-P5372
CAS No.: 211190-38-4
Research Areas:
Cat. No.: HY-D3251
Cat. No.: HY-K3038
MCE Sodium Bicarbonate Solution (7.5%) is designed to adjust the bicarbonate buffering system of cell culture media. Under appropriate CO2 culture conditions, sodium bicarbonate helps maintain physiological pH, neutralizes acidic metabolites produced by cellular metabolism, and provides a stable environment for cell growth. It also supplies bicarbonate ions required for certain cellular metabolic processes.
Cat. No.: HY-D3283
CAS No.: 2158197-66-9
Cat. No.: HY-D3007
Cat. No.: HY-111289
CAS No.: 852838-07-4
Target:
Research Areas:
Tec-IN-14 blocks the interaction between Tec kinase and FGF2 with an IC50 of 7.0 μM. Tec-IN-14 inhibits the non-classical secretion of FGF2 in cells. Tec-IN-14 suppresses the tyrosine phosphorylation of FGF2 in a cellular environment. Tec-IN-14 is applicable to research related to cancer .
Cat. No.: HY-D3074
Target:
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TCM-4COOH is an AIE-active fluorescent probe for calcium ions. TCM-4COOH relies on aggregation-induced emission activity, and its carboxyl chelating group can bind to Ca 2+ and Mg 2+ to form insoluble aggregates, triggering fluorescence enhancement via restricting intramolecular motion (Ex/Em = 477/603 nm). TCM-4COOH shows pH independence in physiological environments (pH 4-9), can be strongly activated at Ca 2+ concentrations ranging from low nM to mM, and has a stronger binding ability to Ca 2+ than to Mg 2+. TCM-4COOH, as its acetoxymethyl ester derivative TCM-AM, can penetrate cell membranes for intracellular detection. TCM-4COOH can be used for imaging of cellular calcium overload, detection of bone microcracks, and studies related to calcium-rich biological environments .
Cat. No.: HY-D3088
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CQPP is a Fluorescent probe designed for monitoring polarity changes in the cellular microenvironment, including polarity tracking of lipid droplets/nuclei during ferroptosis. CQPP exhibits ratiometric fluorescence emission and fluorescence lifetime variations in response to polarity changes; a nonpolar environment stimulates fluorescence from the locally excited (LE) state, while a polar environment drives solvation relaxation to the intramolecular charge transfer (ICT) state, which attenuates the LE emission at ~470 nm and simultaneously enhances the ICT emission at ~670 nm. CQPP binds to intranuclear DNA through electrostatic interactions and hydrogen bonds in the DNA minor groove, which enhances its emission at ~670 nm and prolongs its fluorescence lifetime. CQPP can simultaneously target lipid droplets (green LE fluorescence) and the nucleus (red ICT fluorescence). The detection wavelengths of CQPP are Ex/Em = 405/470 nm and Ex/Em = 405/670 nm, and it also supports fluorescence lifetime imaging via 810 nm two-photon excitation .
Cat. No.: HY-W583868R
CAS No.: 26662-94-2
Synonyms: 1,2-POPE (Standard); 16:0-18:1 PE (Standard)
Target:
Research Areas:
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (Standard) (1,2-POPE (Standard)) is the analytical standard of 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (HY-W583868). This product is intended for research and analytical applications. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .
Cat. No.: HY-W583868S
Synonyms: 1,2-POPE-d62; 16:0-18:1 PE-d62
Cat. No.: HY-L251
91 compounds
Ionizable lipids are a class of specialized, functional lipid molecules with pH-sensitive charge characteristics. They are primarily divided into two major categories: ionizable cationic lipids and ionizable anionic lipids, though the term typically specifies ionizable cationic lipids within the biomedical field. Structurally, these lipids consist of an ionizable hydrophilic headgroup, a biodegradable linker, and hydrophobic tails. Their primary application is serving as the key delivery vehicle in lipid nanoparticles (LNPs) to encapsulate negatively charged nucleic acid macromolecules, such as mRNA vaccines, siRNA therapeutics, and CRISPR gene-editing components. In a physiological, neutral environment, they remain electrically neutral to minimize systemic toxicity and prolong circulation time. Upon entering the acidic microenvironment of cellular endosomes, however, they undergo protonation to become positively charged, thereby inducing membrane fusion and enabling the highly efficient intracellular release of the nucleic acid cargo. Consequently, they serve as the technological cornerstone for bringing nucleic acid therapies into clinical application.
To accelerate the translational process of cutting-edge nucleic acid drugs, MCE has meticulously constructed an ionizable lipid compound library containing 91 high-performance molecules, aiming to provide researchers and pharmaceutical professionals with a high-throughput, multi-dimensional lipid screening platform.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
