2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA 

Cat. No.: HY-P5372A Pureza: 99.78%
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Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.

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Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA Estructura química

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Other Forms of Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA:

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA Related Antibodies

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Ver todos los productos específicos de isoformas Protease Activated Receptor (PAR):

Ver todas las isoformas
PAR1 PAR2 PAR4

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Descripciòn

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'[1].

IC50 & Target[1]

PAR1

 

Peso molecular

883.02 (free base)

Fòrmula

C42H63FN12O8.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Ala-{Phe(p-Fluoro)}-Arg-{Cha}-{Cit}-Tyr-NH2
Sequence Shortening

A-{Phe(p-Fluoro)}-R-{Cha}-{Cit}-Y-NH2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2Protease Activated Receptor (PAR)Thrombin receptorsBioactive peptideProtease activating receptor 1PAR-1AgonistThrombinHepatocellular carcinomaInhibitorinhibitorinhibit

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Nombre del producto:
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA
Cat. No.:
HY-P5372A
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MCE Japan Authorized Agent:

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