complement component

By Targets:	Complement System (18) Amino Acid Derivatives (1) Amylin Receptor (1) Amyloid-β (1) Apoptosis (3) Caspase (1) CGRP Receptor (1) Fatty Acid Synthase (FASN) (1) Interleukin Related (1) Liposome (1) NOD-like Receptor (NLR) (1) SARS-CoV (3) Small Interfering RNA (siRNA) (1) Toll-like Receptor (TLR) (1) α-synuclein (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (16) Metabolic Disease (1) Neurological Disease (4)
Oligonucleotides:	Aptamers (1) Phospholipids (1) siRNA drugs (3) siRNAs (3)

Targets Recommended: Complement System

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3502

Zilucoplan RA101495; RA3193	Complement System	Inflammation/Immunology
Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan can be used in research of immune-mediated necrotising myopathy (IMNM) .

HY-P1717

AMY-101 Maximum Cited Publications 7 Publications Verification Cp40	Complement System SARS-CoV	Inflammation/Immunology
AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (K_D = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .

HY-NP004

Cobra Venom Factor CVF	Complement System	Inflammation/Immunology
Cobra Venom Factor (CVF) is a selective activator targeting complement components C3, C5, and factor B in the complement system. After binding to factor B, Cobra Venom Factor is cleaved by factor D, forming a stable C3/C5 convertase resistant to regulatory proteins H and I. This continuously hydrolyzes C3 and C5, depleting serum complement while inducing neutrophil migration, vascular leakage, and increased TNF-α levels. Cobra Venom Factor can be used to deplete complement and mimic complement activation-related pathological states, and is applied in animal models of complement-mediated diseases such as acute respiratory distress syndrome (ARDS), sepsis, and shock. Cobra Venom Factor can be isolated from the venom of cobras (e.g., Naja atra, Naja melanoleuca, Naja kaouthia, etc.) .

HY-P991127

Claseprubart DNTH103	Complement System	Inflammation/Immunology
Claseprubart (DNTH103) is an inhibitor targeting C1s of the complement system and an inhibitor of the C1 component of the complement cascade. Claseprubart is in phase 2 clinical evaluation. Claseprubart has application potential in research related to multifocal motor neuropathy and generalized myasthenia gravis .

HY-P99050

Sutimlimab BIVV009; IPN-009; TNT009	Complement System	Cardiovascular Disease Inflammation/Immunology
Sutimlimab is a humanized monoclonal IgG4 antibody. Sutimlimab inhibits complement protein component 1, s subcomponent (C1s). Sutimlimab blocks C3 and C4 activation. Sutimlimab can be used for the research of cold agglutinin disease and complement-mediated hemolytic uremic syndrome .

HY-P1717B

AMY-101 acetate Maximum Cited Publications 7 Publications Verification Cp40 acetate	Complement System SARS-CoV	Inflammation/Immunology
AMY-101 acetate (Cp40 acetate), a peptidic inhibitor of the central complement component C3 (K_D = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 acetate (Cp40 acetate) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .

HY-P1717A

AMY-101 TFA Maximum Cited Publications 7 Publications Verification Cp40 TFA	Complement System SARS-CoV	Inflammation/Immunology
AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (K_D = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .

HY-P99358

Dezamizumab GSK 2398852; Anti-Serum Amyloid P/SAP Reference Antibody (dezamizumab)	Complement System	Inflammation/Immunology
Dezamizumab (GSK 2398852) is a fully humanized clonal IgG1 antibody against serum amyloid P component (SAP) with complement activation and amyloid clearance-inducing activities. Dezamizumab binds to SAP associated with amyloid deposits to form complexes that activate complement and mediate phagocytic clearance, triggering activation of the classical complement pathway. Dezamizumab can be used for the research of systemic amyloidosis .

HY-145720

Cemdisiran ALN-CC5	Complement System Small Interfering RNA (siRNA)	Metabolic Disease
Cemdisiran (ALN-CC5) is an N-acetylgalactosamine-conjugated RNAi agent and also a complement component C5 inhibitor. Cemdisiran targets C5 mRNA, cleaves C5 mRNA via the endogenous RNA interference pathway, and inhibits the production of C5 protein in the liver. Cemdisiran exerts a dose-dependent inhibitory effect on total C5 concentrations in cynomolgus monkeys. When used in combination with Pozelimab (HY-P99786) in cynomolgus monkeys, Cemdisiran achieves a more sustained and complete inhibitory effect on complement activity. Cemdisiran can be used in the research of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases .

HY-P10633

SmBiT Tag	Amino Acid Derivatives	Others
SmBiT Tag is an 11-amino-acid short peptide with extremely low natural affinity for LgBiT, with a K_d value of approximately 190 μM. It serves as a core component of the NanoLuc Binary Technology (NanoBiT) system. NanoBiT is a bioluminescent reporter system based on protein fragment complementation technology, which is used to monitor dynamic protein-protein interactions in live cells and in vitro .

HY-148457

Avacincaptad pegol Izervay	Complement System	Infection Neurological Disease Inflammation/Immunology
Avacincaptad pegol (Izervay) is a selective inhibitor targeting complement component C5, and is a pegylated ribonucleic acid aptamer. Avacincaptad pegol inhibits the cleavage of C5 into pro-inflammatory C5a and C5b, which forms the membrane attack complex (C5b-9), thereby reducing inflammatory cell recruitment and retinal cell damage. Avacincaptad pegol can slow the growth of geographic atrophy (GA) lesions and reduce the risk of persistent vision loss. Avacincaptad pegol can be used in research of geographic atrophy associated with age-related macular degeneration (AMD) and has been approved by the FDA .

HY-128342

Complement C5-IN-1 1 Publications Verification	Complement System	Inflammation/Immunology
Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC₅₀ of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .

HY-112307A

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium	Liposome	Cardiovascular Disease Inflammation/Immunology
(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q) .

HY-P10227

Xelafaslatide ONL-1204	Fatty Acid Synthase (FASN) Apoptosis Interleukin Related Toll-like Receptor (TLR) NOD-like Receptor (NLR) Caspase	Neurological Disease
Xelafaslatide (ONL-1204) is a Fas receptor antagonist. Xelafaslatide blocks the Fas receptor signaling pathway and inhibits downstream apoptosis and inflammatory pathways. Xelafaslatide suppresses neuroinflammation and microglial activation in glaucoma models, protects retinal ganglion cells and prevents axonal degeneration. Xelafaslatide is applicable to relevant research on glaucoma .

HY-N1464A

Aristolone	Complement System Apoptosis	Cancer
Aristolone is a sesquiterpene that can be isolated from Aristolochia debilis, Rosmarinus officinalis and Ficus Auriculata. Aristolone in Ara Fruit can be used as a prediction of apoptosis in HeLa cells. Aristolone inhibits the C1 complement component. Aristolone produces cytotoxicity effects on cells. Aristolone has anticancer properties and can be studied in research for cervical cancer .

HY-P3502B

Zilucoplan (PEG2)	Complement System	Inflammation/Immunology
Zilucoplan (PEG2) is a Zilucoplan (HY-P3502) derivative, where the linker section replaces PEG24 by PEG2. Zilucoplan is a potent complement component 5 (C5) inhibitor .

HY-177621A

Cevolisiran sodium	Complement System	Inflammation/Immunology
Cevolisiran sodium, a siRNA, is a complement component 3 (C3) synthesis reducer.

HY-177621

Cevolisiran	Complement System	Inflammation/Immunology
Cevolisiran, a siRNA, is a complement component 3 (C3) synthesis reducer.

HY-N7401

Entadamide-A-β-D-glucopyranoside	Complement System	Others
Entadamide-A-β-D-glucopyranoside is one of the major components in the seeds of Entada phaseoloides. Entadamide-A-β-D-glucopyranoside has anti-complement activitie .

HY-P3502A

Zilucoplan TFA RA101495 TFA; RA3193 TFA	Complement System	Inflammation/Immunology
Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan TFA can be used in research of immune-mediated necrotising myopathy (IMNM) .

HY-P99886

Pexelizumab h5G1. 1-SC	Complement System Apoptosis	Cardiovascular Disease Neurological Disease
Pexelizumab (h5G1. 1-SC) is a humanized scFv monoclonal antibody directed against the C5 complement component. Pexelizumab inhibits apoptosis and leukocyte infiltration. Pexelizumab can be used for the research of cerebral IR injury and myocardial infarction .

HY-114613

D-Trp-Aib	Amyloid-β α-synuclein CGRP Receptor Amylin Receptor	Neurological Disease Inflammation/Immunology
D-Trp-Aib is a dipeptide and amyloid-β inhibitor with a K_d of 29.6 nM. D-Trp-Aib triggers formation of non-toxic, non-β-sheet, amorphous amyloid β clusters from misfolded amyloid β monomers and toxic amyloid β oligomers, and reduces toxic amyloid β_1-42 deposits. D-Trp-Aib inhibits amyloid fibril formation of α‑synuclein, IAPP and calcitonin. D-Trp-Aib can be used for the research of Alzheimer's disease .

Cat. No.	Product Name

HY-L021P

Natural Product Library Plus	6,181 compounds
Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery. Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored. MCE provides a unique collection of 6,181 natural compounds that contains Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library Plus, with more powerful screening capability, further complements Natural Product Library (HY-L021) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

Natural Product Library Plus

6,181 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery.

Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored.

MCE provides a unique collection of 6,181 natural compounds that contains Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library Plus, with more powerful screening capability, further complements Natural Product Library (HY-L021) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

Cat. No.	Product Name	Type

HY-NP004

Cobra Venom Factor CVF	Biochemical Assay Reagents
Cobra Venom Factor (CVF) is a selective activator targeting complement components C3, C5, and factor B in the complement system. After binding to factor B, Cobra Venom Factor is cleaved by factor D, forming a stable C3/C5 convertase resistant to regulatory proteins H and I. This continuously hydrolyzes C3 and C5, depleting serum complement while inducing neutrophil migration, vascular leakage, and increased TNF-α levels. Cobra Venom Factor can be used to deplete complement and mimic complement activation-related pathological states, and is applied in animal models of complement-mediated diseases such as acute respiratory distress syndrome (ARDS), sepsis, and shock. Cobra Venom Factor can be isolated from the venom of cobras (e.g., Naja atra, Naja melanoleuca, Naja kaouthia, etc.) .

Cobra Venom Factor

CVF

Biochemical Assay Reagents

Cobra Venom Factor (CVF) is a selective activator targeting complement components C3, C5, and factor B in the complement system. After binding to factor B, Cobra Venom Factor is cleaved by factor D, forming a stable C3/C5 convertase resistant to regulatory proteins H and I. This continuously hydrolyzes C3 and C5, depleting serum complement while inducing neutrophil migration, vascular leakage, and increased TNF-α levels. Cobra Venom Factor can be used to deplete complement and mimic complement activation-related pathological states, and is applied in animal models of complement-mediated diseases such as acute respiratory distress syndrome (ARDS), sepsis, and shock. Cobra Venom Factor can be isolated from the venom of cobras (e.g., Naja atra, Naja melanoleuca, Naja kaouthia, etc.) .

HY-112307A

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium	Biochemical Assay Reagents
(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q) .

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium

Biochemical Assay Reagents

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q) .

Cat. No.	Product Name	Target	Research Area

HY-P3502

Zilucoplan RA101495; RA3193	Complement System	Inflammation/Immunology
Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan can be used in research of immune-mediated necrotising myopathy (IMNM) .

HY-P1717

AMY-101 Maximum Cited Publications 7 Publications Verification Cp40	Complement System SARS-CoV	Inflammation/Immunology
AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (K_D = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .

HY-P1717B

AMY-101 acetate Maximum Cited Publications 7 Publications Verification Cp40 acetate	Complement System SARS-CoV	Inflammation/Immunology
AMY-101 acetate (Cp40 acetate), a peptidic inhibitor of the central complement component C3 (K_D = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 acetate (Cp40 acetate) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .

HY-P1717A

AMY-101 TFA Maximum Cited Publications 7 Publications Verification Cp40 TFA	Complement System SARS-CoV	Inflammation/Immunology
AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (K_D = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .

HY-P10633

SmBiT Tag	Amino Acid Derivatives	Others
SmBiT Tag is an 11-amino-acid short peptide with extremely low natural affinity for LgBiT, with a K_d value of approximately 190 μM. It serves as a core component of the NanoLuc Binary Technology (NanoBiT) system. NanoBiT is a bioluminescent reporter system based on protein fragment complementation technology, which is used to monitor dynamic protein-protein interactions in live cells and in vitro .

HY-P10227

Xelafaslatide ONL-1204	Fatty Acid Synthase (FASN) Apoptosis Interleukin Related Toll-like Receptor (TLR) NOD-like Receptor (NLR) Caspase	Neurological Disease
Xelafaslatide (ONL-1204) is a Fas receptor antagonist. Xelafaslatide blocks the Fas receptor signaling pathway and inhibits downstream apoptosis and inflammatory pathways. Xelafaslatide suppresses neuroinflammation and microglial activation in glaucoma models, protects retinal ganglion cells and prevents axonal degeneration. Xelafaslatide is applicable to relevant research on glaucoma .

HY-P3502A

Zilucoplan TFA RA101495 TFA; RA3193 TFA	Complement System	Inflammation/Immunology
Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan TFA can be used in research of immune-mediated necrotising myopathy (IMNM) .

HY-P5528

2Abz-SLGRKIQIK(Dnp)-NH2	Peptides	Others
2Abz-SLGRKIQIK(Dnp)-NH2 is a biological active peptide. (This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The complement system is a central component of host defense but can also contribute to the inflammation seen in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. This peptide employs 2Abz/Dnp FRET pair for quantitation of complement enzyme activity.)

Cat. No.	Product Name	Target	Research Area	Image

HY-P991127

Claseprubart DNTH103	Complement System	Inflammation/Immunology
Claseprubart (DNTH103) is an inhibitor targeting C1s of the complement system and an inhibitor of the C1 component of the complement cascade. Claseprubart is in phase 2 clinical evaluation. Claseprubart has application potential in research related to multifocal motor neuropathy and generalized myasthenia gravis .

HY-P99050

Sutimlimab BIVV009; IPN-009; TNT009	Complement System	Cardiovascular Disease Inflammation/Immunology
Sutimlimab is a humanized monoclonal IgG4 antibody. Sutimlimab inhibits complement protein component 1, s subcomponent (C1s). Sutimlimab blocks C3 and C4 activation. Sutimlimab can be used for the research of cold agglutinin disease and complement-mediated hemolytic uremic syndrome .

HY-P99358

Dezamizumab GSK 2398852; Anti-Serum Amyloid P/SAP Reference Antibody (dezamizumab)	Complement System	Inflammation/Immunology
Dezamizumab (GSK 2398852) is a fully humanized clonal IgG1 antibody against serum amyloid P component (SAP) with complement activation and amyloid clearance-inducing activities. Dezamizumab binds to SAP associated with amyloid deposits to form complexes that activate complement and mediate phagocytic clearance, triggering activation of the classical complement pathway. Dezamizumab can be used for the research of systemic amyloidosis .

HY-P99886

Pexelizumab h5G1. 1-SC	Complement System Apoptosis	Cardiovascular Disease Neurological Disease
Pexelizumab (h5G1. 1-SC) is a humanized scFv monoclonal antibody directed against the C5 complement component. Pexelizumab inhibits apoptosis and leukocyte infiltration. Pexelizumab can be used for the research of cerebral IR injury and myocardial infarction .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1464A

Aristolone	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Plants Disease Research Fields Source Classification Cancer	Complement System Apoptosis
Aristolone is a sesquiterpene that can be isolated from Aristolochia debilis, Rosmarinus officinalis and Ficus Auriculata. Aristolone in Ara Fruit can be used as a prediction of apoptosis in HeLa cells. Aristolone inhibits the C1 complement component. Aristolone produces cytotoxicity effects on cells. Aristolone has anticancer properties and can be studied in research for cervical cancer .

HY-N7401

Entadamide-A-β-D-glucopyranoside	Alkaloids other families Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Complement System
Entadamide-A-β-D-glucopyranoside is one of the major components in the seeds of Entada phaseoloides. Entadamide-A-β-D-glucopyranoside has anti-complement activitie .

Species:	Human (14) Rat (1) Mouse (5) Cynomolgus (4)
Tag:	His (19) Tag Free (3) Myc (1) Fc (2)
Source:	HEK293 (14) E. coli (10)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74372

	*C7/Complement* component C7 Protein, Human (HEK293, Fc)** complement component C7; C7	Human	HEK293
	C7, also known as complement component C7 protein, is a key component of the membrane attack complex (MAC) and plays a key role in innate and adaptive immune responses. As a component of MAC, C7 actively participates in the formation of target cell plasma membrane pores. C7/Complement component C7 Protein, Human (HEK293, Fc) is the recombinant human-derived C7/Complement component C7 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74373

	*C6/Complement* component C6 Protein, Human (HEK293, His)** complement component C6; C6	Human	HEK293
	C6/Complement component C6 Protein is a part of the lytic membrane attack complex formed during complement activation, which has an indispensable role in innate and acquired immune responses by forming pores in the plasma membrane of target cells, as well as cancer immune surveillance. It is a component of the complement cascade which can be incorporated into the cell membrane and cause cell lysis. People with C6 deficiency are prone to bacterial infection. C6/Complement component C6 Protein, Human (HEK293, His) is the recombinant human-derived C6/Complement component C6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74371

	*C7/Complement* component C7 Protein, Human (HEK293, His, solution)** complement component C7; C7	Human	HEK293
	C7, also known as complement component C7 protein, is a key component of the membrane attack complex (MAC) and plays a key role in innate and adaptive immune responses. As a component of MAC, C7 actively participates in the formation of target cell plasma membrane pores. C7/Complement component C7 Protein, Human (HEK293, His, solution) is the recombinant human-derived C7/Complement component C7 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78595

	Complement C5a Protein, Cynomolgus C5a; complement component 5a	Cynomolgus	E. coli
	Complement C5 is activated by C5 convertase, inducing C5-C9 assembly to form the membrane attack complex. The transient C6 binding site on C5b is critical for the formation of the cleavage complex. Complement C5a Protein, Cynomolgus is the recombinant cynomolgus-derived Complement C5/C5a protein, expressed by E. coli , with tag free.

HY-P705312

	Complement C9 Protein, Human (His, Myc) complement component C9; C9	Human	E. coli

HY-P75332

	Complement C3 Protein, Cynomolgus (HEK293, His) Anaphylatoxin; C3; complement component C3a	Cynomolgus	HEK293
	Complement C3 proteins play a key role in initiating the complement system through processing by C3 convertase in the classical and alternative pathways. Upon activation, C3b covalently binds to the surface, while C3a (anaphylatoxin produced by proteolysis of C3) mediates local inflammation. Complement C3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Complement C3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P705491

	Complement C5/C5a Protein, Cynomolgus (His) C5a; complement component 5a	Cynomolgus	E. coli

HY-P7824

	Complement C8G Protein, Human (His, solution) rHucomplement component C8 gamma chain/C8G, His; complement component C8 gamma chain; C8G	Human	E. coli
	C8G/C8 γ is the γ subunit of the C8 protein of the complement system and is mainly localized in brain astrocytes. C8G/C8 γ is a neuroinflammation inhibitor that interacts with S1PR2 and jointly antagonizes the pro-inflammatory activity of S1P in microglia. Complement C8G Protein, Human (His, solution) is the recombinant human-derived Complement C8G protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7824A

	*Complement C8G Protein, Human (N-6His)** rHucomplement component C8 gamma chain/C8G, His; complement component C8 gamma chain; C8G	Human	E. coli
	Complement C8G Protein, Human (N-6His) is the recombinant human-derived Complement C8G protein, expressed by E. coli, with N-6His tag.

HY-P76185

	HABP1/C1QBP Protein, Mouse (His) 1 Publications Verification complement component 1 Q subcomponent-binding protein, mitochondrial; HABP1	Mouse	E. coli
	The HABP1/C1QBP proteins are part of the MAM33 family, related to a unique family of proteins known for unique characteristics and functions. Among the MAM33 family, HABP1 may play an important role in related cellular processes, but its specific function still needs to be explored. HABP1/C1QBP Protein, Mouse (His) is the recombinant mouse-derived HABP1/C1QBP protein, expressed by E. coli , with N-His labeled tag.

HY-P7863

	Complement C3a Protein, Mouse Maximum Cited Publications 7 Publications Verification rMucomplement C3/C3a; complement component C3a; Anaphylatoxin; C3a	Mouse	E. coli
	Complement C3/C3a protein activates the complement system, playing a central role in both classical and alternative pathways. C3b binds covalently to cell surface carbohydrates or immune aggregates, while C3a acts as an inflammatory mediator, inducing neutrophil chemoattraction and promoting smooth muscle contraction, increased vascular permeability, and histamine release. The shorter isoform of C3a stimulates B-cells. Complement C3a Protein, Mouse is the recombinant mouse-derived Complement C3/C3a protein, expressed by E. coli , with tag free.

HY-P7862

	Complement C3a Protein, Human 5 Publications Verification rHucomplement C3/C3a; complement component C3a; C3a; Anaphylatoxin	Human	E. coli
	Complement C3/C3a protein plays a key role in initiating the complement system through processing by C3 convertase in both the classical and alternative pathways. Complement C3/C3a protein is involved in various immune and inflammatory responses and also has a role in regulating blood pressure. Complement C3a Protein, Human is a recombinant Complement C3/C3a protein expressed in E. coli, no tag..

HY-P700696

	*C1s/Complement* component C1s Protein, Human (HEK293, His)** complement C1s subcomponent; C1 esterase;	Human	HEK293
	C1s/Complement component C1s, a serine protease and B chain, forms C1 with C1q and C1r, initiating the classical complement pathway. Activated by C1r, C1s then activates downstream components C2 and C4, crucially driving the complement system cascade. C1s/Complement component C1s Protein, Human (HEK293, His) is the recombinant human-derived C1s/Complement component C1s protein, expressed by HEK293 , with C-His labeled tag.

HY-P705583

	C8g Protein, Mouse (His) C8g; complement component C8 gamma chain	Mouse	E. coli

HY-P700398

	C5AR1 Protein-VLP, Human (HEK293, His) complement component 5a receptor 1; C5R1, complement component 5 receptor 1 (C5a ligand); C5a anaphylatoxin chemotactic receptor; C5A; C5AR; CD88; C5a-R; C5a ligand; C5a anaphylatoxin receptor; complement component 5 receptor 1; C5R1;	Human	HEK293
	C5AR1 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P7692

	HABP1/C1QBP Protein, Human (His) rHuHABP1/C1QBP, His; complement component 1 Q subcomponent-binding protein, mitochondrial; HABP1	Human	E. coli
	HABP1/C1QBP Protein, Human (His) is a recombinant human HABP1 (hyaluronan-binding protein 1)/C1QBP (complement component 1, q subcomponent binding protein) produced in HEK293 cells, with His tag. HABP1/C1QBP is a ubiquitously present glycoprotein having specific affinity towards hyaluronan (HA).

HY-P75373

	CD93/C1qR1 Protein, Mouse (HEK293, His) complement component C1q Receptor; CD93; C1qRp; Ly-68; C1qr1	Mouse	HEK293
	The CD93/C1qR1 protein, as a receptor or part of a larger complex, is a multifunctional mediator in immune recognition and cellular interactions.It has been shown to play a role in coordinating immune responses as a binding site for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA).CD93/C1qR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD93/C1qR1 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P75661

	CD93/C1qR1 Protein, Rat (HEK293, His) complement component C1q Receptor; CD93; C1qRp; Ly-68; C1qr1	Rat	HEK293
	The CD93/C1qR1 protein is a receptor or component of a larger complex that is critical in immune recognition and response. It acts as a receptor for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA), suggesting a role in interactions with multiple immune components. CD93/C1qR1 Protein, Rat (HEK293, His) is the recombinant rat-derived CD93/C1qR1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P7691

	CD93/C1qR1 Protein, Human (HEK293, His) 1 Publications Verification rHuCD93, His; complement component C1q Receptor; Matrix-Remodeling-Associated Protein 4CD93; CD93	Human	HEK293
	CD93/C1qR1 Protein, Human (HEK293, His) is a recombinant human CD93 produced in HEK293 cells, with His tag. CD93 is a type 1 transmembrane glycoprotein.

HY-P703881

	CD93/C1qR1 Protein, Human (HEK293, hFc) rHuCD93, His; complement component C1q Receptor; Matrix-Remodeling-Associated Protein 4CD93; CD93	Human	HEK293
	The CD93/C1qR1 protein is thought to be a receptor or part of a larger complex and plays a crucial role in immune recognition by binding to C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA) . Its interaction with these immune factors suggests a role in coordinating the innate immune response. CD93/C1qR1 Protein, Human (HEK293, hFc) is the recombinant human-derived C1qR1/CD93 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P703882

	CD93/C1qR1 Protein, Human (HEK293, His, solution) rHuCD93, His; complement component C1q Receptor; Matrix-Remodeling-Associated Protein 4CD93; CD93	Human	HEK293
	The CD93/C1qR1 protein is thought to be a receptor or part of a larger complex and plays a crucial role in immune recognition by binding to C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA) . Its interaction with these immune factors suggests a role in coordinating the innate immune response. CD93/C1qR1 Protein, Human (HEK293, His, solution) is the recombinant human-derived C1qR1/CD93 protein, expressed by HEK293, with C-His labeled tag.

HY-P700464

	CD93/C1qR1 Protein, Macaca fascicularis (HEK293, His) rHuCD93, His; complement component C1q Receptor; Matrix-Remodeling-Associated Protein 4CD93; CD93	Cynomolgus	HEK293
	CD93/C1qR1 Protein lacks conserved residue(s) crucial for feature annotation propagation. CD93/C1qR1 Protein, Macaca fascicularis (HEK293, His) is the recombinant cynomolgus-derived CD93/C1qR1 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P74371A

	*C7/Complement* component C7 Protein, Human (HEK293, C-10His)* Sperm Equatorial Segment Protein 1; ESP; Equatorial Segment Protein; SP-ESP; Glycosylated 38 kDa Sperm Protein C-7/8; SPESP1	Human	HEK293
	C7, also known as complement component C7 protein, is a key component of the membrane attack complex (MAC) and plays a key role in innate and adaptive immune responses. As a component of MAC, C7 actively participates in the formation of target cell plasma membrane pores. C7/Complement component C7 Protein, Human (HEK293, C-10His) is the recombinant human-derived C7/Complement component C7 protein, expressed by HEK293, with C-10His labeled tag.

HY-P704127

	MASP1 Protein, Mouse (HEK293, His) MASP3; MASP1; CRARF1; RaRF; Mannan-binding lectin serine protease 1; complement factor MASP-3; complement-activating component of Ra-reactive factor; Mannose-binding lectin-associated serine protease 1 (MASP-1); Mannose-binding protein-associated serine protease; Ra-reactive factor serine protease p100 (RaRF); Serine protease 5	Mouse	HEK293
	MASP1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MASP1 protein, expressed by HEK293, with C-His tag.

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Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (4) Rabbit (8)
Reactivity:	Human (11) Mouse (4) Rat (4)
Application:	IHC-P (7) ICC/IF (5) IF-Tissue (2) IP (3) IHC-F (2) WB (8) FC (4) ELISA (1)
Isotype:	IgG (8) IgG1 (4)
Conjugation:	Non-conjugated (12)
Clonality:	Polyclonal (1) Monoclonal (8) Recombinant (5)
Modification:	Unmodified (9)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85894

	CD35 Antibody (YA5586) C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD 35; CD35; CD35 antigen; complement component; 3b/4b; receptor 1; Knops blood group; complement component; 3b/4b; receptor 1 including Knops blood group system; complement component receptor 1; complement receptor 1; complement receptor type 1; CR 1; CR1; CR1_HUMAN; KN; Knops blood group antigen	IHC-P, WB, ICC/IF, ELISA	Human
	CD35 Antibody (YA5586) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD35.

HY-P81185

	C5b-9 Antibody 1 Publications Verification C5; C6; C7; C8; C9; complement component 5; complement component 6; complement component 7; complement component 8; complement component 9; MAC; Membrane attack complex; TCC; Terminal complement complex.	WB, IHC-P, IHC-F, ICC/IF	Human, Rat
	C5b-9 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to C5b-9.

HY-P81468

	C1QA Antibody (YA1213) C1qa; complement C1q subcomponent subunit A; complement component 1 q subcomponent A chain; complement component 1 q subcomponent alpha polypeptide;	IHC-P	Human
	C1QA Antibody (YA1213) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to C1QA.

HY-P87384

	C7 Antibody (YA7067) C7 antibody; CO7_HUMAN antibody; complement component 7 antibody; complement component C7 antibody	WB, ICC/IF, FC	Human
	C7 Antibody (YA7067) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C7.

HY-P81468A

	C1QA Antibody (YA1213)(PBS only) C1qa; complement C1q subcomponent subunit A; complement component 1 q subcomponent A chain; complement component 1 q subcomponent alpha polypeptide;	IHC-P	Human
	C1QA Antibody (YA1213) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to C1QA.

HY-P88245

	C1R Antibody (YA7929) complement component 1; r subcomponent	FC	Human
	C1R Antibody (YA7929) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1R.

HY-P88245A

	C1R Antibody (YA7929)(PBS only) complement component 1; r subcomponent	FC	Human
	C1R Antibody (YA7929) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1R.

HY-P81889

	C1QB Antibody (YA1634) C1qb; complement component 1 q subcomponent B chain	WB, IHC-P, ICC/IF	Human
	C1QB Antibody (YA1634) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to C1QB.

HY-P83768

	CD11c Antibody(YA3565) 95 alpha chain antibody; 95 antibody; CD 11c antibody; CD11 antigen like family member C antibody; CD11 antigen-like family member C antibody; CD11c antibody; CD11c antigen antibody; complement component 3 receptor 4 subunit antibody; CR4 antibody; Integrin alpha X antibody; Integrin alpha X chain antibody; Integrin alpha-X antibody; Integrin aX antibody; Integrin subunit alpha X antibody; integrin, alpha X (antigen CD11C (p150), alpha polypeptide) antibody; integrin, alpha X (complement component 3 receptor 4 subunit antibody; ITAX_HUMAN antibody; ITGAX antibody; LEU M5 alpha subunit antibody; Leu M5 antibody	WB, IHC-P, IHC-F, IF-Tissue	Mouse
	CD11c Antibody(YA3565) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD11c.

HY-P82566

	GC1q R Antibody (YA2311) C1QBP; GC1QBP; HABP1; SF2P32; complement component 1 Q subcomponent-binding protein; mitochondrial; GC1q-R protein; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p33	WB, IP	Human, Mouse, Rat
	GC1q R Antibody (YA2311) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GC1q R.

HY-P81562

	CD21 Antibody (YA1307) C3DR antibody; CD 21 antibody; CD21 antibody; complement C3d receptor antibody; complement component (3d/Epstein Barr virus) receptor 2 antibody; complement receptor type 2 antibody; CR antibody; Cr2 antibody; CR2_HUMAN antibody; CVID7 antibody; EBV receptor antibody; EBV-R antibody; Epstein Barr virus receptor antibody; Epstein-Barr virus receptor antibody; EVBR antibody; SLEB9 antibody;	WB, IHC-P, ICC/IF, IP, FC, IF-Tissue	Human, Mouse, Rat
	CD21 Antibody (YA1307) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD21.

HY-P82566A

	GC1q R Antibody (YA2311)(PBS only) C1QBP; GC1QBP; HABP1; SF2P32; complement component 1 Q subcomponent-binding protein; mitochondrial; GC1q-R protein; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p33	WB, IP	Human, Mouse, Rat
	GC1q R Antibody (YA2311) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GC1q R.

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Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
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Conjugation
Clonality
Immunogen
Appearance
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SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-145720

Cemdisiran ALN-CC5		siRNAs siRNA drugs
Cemdisiran (ALN-CC5) is an N-acetylgalactosamine-conjugated RNAi agent and also a complement component C5 inhibitor. Cemdisiran targets C5 mRNA, cleaves C5 mRNA via the endogenous RNA interference pathway, and inhibits the production of C5 protein in the liver. Cemdisiran exerts a dose-dependent inhibitory effect on total C5 concentrations in cynomolgus monkeys. When used in combination with Pozelimab (HY-P99786) in cynomolgus monkeys, Cemdisiran achieves a more sustained and complete inhibitory effect on complement activity. Cemdisiran can be used in the research of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases .

HY-148457

Avacincaptad pegol Izervay		Aptamers
Avacincaptad pegol (Izervay) is a selective inhibitor targeting complement component C5, and is a pegylated ribonucleic acid aptamer. Avacincaptad pegol inhibits the cleavage of C5 into pro-inflammatory C5a and C5b, which forms the membrane attack complex (C5b-9), thereby reducing inflammatory cell recruitment and retinal cell damage. Avacincaptad pegol can slow the growth of geographic atrophy (GA) lesions and reduce the risk of persistent vision loss. Avacincaptad pegol can be used in research of geographic atrophy associated with age-related macular degeneration (AMD) and has been approved by the FDA .

HY-112307A

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium		Phospholipids
(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q) .

HY-177621A

Cevolisiran sodium		siRNAs siRNA drugs
Cevolisiran sodium, a siRNA, is a complement component 3 (C3) synthesis reducer.

HY-177621

Cevolisiran		siRNAs siRNA drugs
Cevolisiran, a siRNA, is a complement component 3 (C3) synthesis reducer.

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