1841136-73-9
Chemical Structure
Zilucoplan
Synonym(s): RA101495; RA3193
- CAS No.: 1841136-73-9
- Formula:C172H278N24O55
- Molecular Weight:3562.18
IUPAC Name: (4S,5S)-1-(3,5-di-tert-butylphenyl)-3-(2-methylnaphthalen-1-yl)-4,5-diphenyl-1,3,2-diazaphospholidine 2-oxide
InChIKey: JDXCOXKBIGBZSK-PSNKNOTQSA-N
SMILES: CCCCCCCCCCCCCCCC(N[C@H](C(O)=O)CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCCCC[C@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N(C([C@@H]2CC(NCCCC[C@H](NC(C)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=CC=C3)C(N2)=O)=O)=O)=O)=O)=O)=O)C)CC(O)=O)=O)C(C)(C)C)=O)CC4=CC=C(O)C=C4)=O)CC5=CNC6=C5C=CC=N6)=O)CCC(O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)C8CCCCC8)=O)C(O)=O)=O)=O)=O
Biological Activity: Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan can be used in research of immune-mediated necrotising myopathy (IMNM)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zilucoplan | 99.71% | Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan can be used in research of immune-mediated necrotising myopathy (IMNM). | ||||||||||||||||||||
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- [1]. Julien S, et, al. Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model. Biomedicines. 2022 Aug 20;10(8):2036. [Content Brief]
- [2]. Gorman DM, et, al. Chemical synthesis and characterisation of the complement C5 inhibitory peptide zilucoplan. Amino Acids. 2021 Jan;53(1):143-147. [Content Brief]
Keywords
