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Cat. No.: HY-P991127

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Biologically Validated

Claseprubart

(Synonyms: DNTH103)

Customer Review

Based on 1 Customer Validation

Claseprubart (DNTH103) is an inhibitor targeting C1s of the complement system and an inhibitor of the C1 component of the complement cascade. Claseprubart is in phase 2 clinical evaluation. Claseprubart has application potential in research related to multifocal motor neuropathy and generalized myasthenia gravis.

For research use only. We do not sell to patients.

Purity: 99%
CAS No.: 2922766-89-8
Molecular Weight:144.638 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Claseprubart Chemical Structure

CAS No.: 2922766-89-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

Complement C1s

In Vitro

Co-incubation of DNTH103 (0.1 μM, 1 μM) with complement-containing serum from AChR-positive myasthenia gravis patients significantly reduces the muscle contraction fatigue index and improves neuromuscular transmission function in a human iPSC-derived motor neuron-muscle cell co-culture myasthenia gravis model. Its efficacy is superior to that of anti-C5 antibody at the same concentration, and it exerts no significant effect on serum samples from healthy individuals^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

716 [NCBI]

Accession

P09871

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG4-kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Loaded Claseprubart on ProA biosensor, can bind HY-P700696 C1s/Complement C1s Protein, Human (HEK293, His) with an affinity constant of 3.648E-09 M as determined in BLI assay.

Chemical Information

CAS No. 2922766-89-8
Appearance Liquid
Molecular Weight 144.638 kDa
Color Colorless to light yellow
SMILES

[Claseprubart]
Synonyms

DNTH103
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Gokhale S, et al. Classical Pathway Inhibition with Anti-active C1s Antibody DNTH103 Prevents Neurotransmission Impairment in a Preclinical Model of Myasthenia Gravis (S15. 001)[C]//Neurology. Hagerstown, MD: Lippincott Williams & Wilkins, 2024, 102(7_supplement_1): 5614.

[2]. Katzberg H, et al. Prospects for multi-focal motor neuropathy treatment by complement inhibition[J]. Expert Opinion on Investigational Drugs, 2025, 34(6): 453-457.

[3]. Ho AWS, et al. Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function. EBioMedicine. 2025;122:106009. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Purity & Documentation
References

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Cat. No.:
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MCE Japan Authorized Agent:

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CAS No.:
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Claseprubart

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

Antibody Inhibitor Library