1 Result for "

diABZI-V/C-DBCO

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "diABZI-V/C-DBCO" in MCE Product Catalog:

Cat. No.: HY-162874
CAS No.: 3035557-60-6
Target:  

STING IFNAR

Research Areas:  

Cancer

diABZI-V/C-DBCO is a STING agonist with an EC50 of 1.47 nM. diABZI-V/C-DBCO activates the STING pathway, induces the production of IFN-I, and stimulates the secretion of IFN-β. diABZI-V/C-DBCO serves as a substrate for cathepsin B, and releases active diABZI-amine via cathepsin B-mediated cleavage. In an orthotopic mouse model of breast cancer, diABZI-V/C-DBCO increases serum IFN-β levels and the frequency of granzyme B + CD8 + T cells. diABZI-V/C-DBCO is applicable to research related to triple-negative breast cancer .
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