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Results for "

dopamine (DA)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine Receptor (38) Dopamine Transporter (9) 5-HT Receptor (8) Adrenergic Receptor (12) Biochemical Assay Reagents (5) Calcium Channel (1) Cannabinoid Receptor (1) Drug Derivative (2) Drug Metabolite (1) Endogenous Metabolite (2) Environmental Pollutants (2) G Protein-coupled Receptor Kinase (GRK) (1) Interleukin Related (1) Isotope-Labeled Compounds (7) Lipoxygenase (1) mAChR (1) mGluR (1) Monoamine Oxidase (2) Monoamine Transporter (1) nAChR (8) Opioid Receptor (2) Potassium Channel (2) Reference Standards (13) Serotonin Transporter (17) Sodium Channel (6) Somatostatin Receptor (1) TRP Channel (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (6) Endocrinology (2) Inflammation/Immunology (3) Metabolic Disease (8) Neurological Disease (70)
Click Chemistry:	Alkynes (2)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Dopamine Receptor Dopamine β-hydroxylase Dopamine Transporter RPE65

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17385

Atomoxetine hydrochloride 4 Publications Verification Tomoxetine hydrochloride; (R)-Tomoxetine hydrochloride; LY 139603	Adrenergic Receptor Serotonin Transporter Sodium Channel	Neurological Disease Cancer
Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with K_i values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .

HY-B0979

Lobeline hydrochloride 1 Publications Verification α-Lobeline hydrochloride; L-Lobeline hydrochloride	nAChR Dopamine Transporter	Neurological Disease
Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation .

HY-B0602

Desvenlafaxine O-Desmethylvenlafaxine	Environmental Pollutants Serotonin Transporter	Neurological Disease
Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC₅₀ values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

HY-14472

Tesofensine NS-2330	Dopamine Transporter Serotonin Transporter	Metabolic Disease
Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC₅₀=6.5 nM), norepinephrine (NE;IC₅₀=1.7 nM), and serotonin (5-HT;IC₅₀=11 nM), and with potentials as an anti-obesity agent . Tesofensine is a CNS acting anti-obesity agent .

HY-14197A

Clorgyline hydrochloride 5+ Cited Publications	Monoamine Oxidase	Metabolic Disease
Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research, structurally related to Pargyline (HY-A0091A). Clorgyline hydrochloride has little effect on the amounts of conjugated dopamine (DA) present in superfusate of slices from rat striatum. Clorgyline hydrochloride contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-10684

Pridopidine ACR16; ASP2314; FR310826	Dopamine Receptor	Neurological Disease
Pridopidine, a *dopamine* (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with K_i between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.

HY-B1110

Nomifensine 5+ Cited Publications (±)-Nomifensine; Nomifensin	Dopamine Receptor Adrenergic Receptor	Neurological Disease
Nomifensine ((±)-Nomifensine) is a potent norepinephrine (NE) and **dopamine (DA) reuptake inhibitor. Nomifensine inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i** values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine has antidepressant and analgesic effects. Nomifensine is used in neurodegenerative diseases, compound addiction, and pain research .

HY-B1110A

Nomifensine maleate 5+ Cited Publications (±)-Nomifensine maleate; Nomifensin maleate	Dopamine Receptor Adrenergic Receptor	Neurological Disease
Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and **dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i** values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

HY-109112

Brilaroxazine RP5063	Dopamine Receptor 5-HT Receptor	Neurological Disease Inflammation/Immunology
Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (K_i=1.5 nM) and 5-HT2A (K_i=2.5 nM), and has antagonist activity at 5-HT2B (K_i=0.19 nM), and 5-HT7 (K_i=2.7 nM) receptors . Brilaroxazine is an atypical antipsychotic agent, and has the potential to improve cognitive impairments in neuropsychiatric and neurological diseases in vivo .

HY-B1382

Pempidine 1,2,2,6,6-Pentamethylpiperidine	nAChR	Cardiovascular Disease Neurological Disease
Pempidine (1,2,2,6,6-Pentamethylpiperidine) is an orally active ganglionic blocking agent used in hypertension-related conditions. Pempidine is a nicotinic receptor blocker. Pempidine can antagonize the nicotine-induced increase of the striatal dopamine (DA) in vitro .

HY-B0602A

Desvenlafaxine succinate hydrate O-Desmethylvenlafaxine succinate hydrate	Serotonin Transporter	Neurological Disease
Desvenlafaxine succinate hydrate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC₅₀ values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate hydrate shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

HY-113257

Dopamine 4-sulfate DA-4S; dopamine 4-Sulfate	Drug Metabolite	Neurological Disease
Dopamine 4-sulfate (DA-4S) is an inactive metabolite of the catecholamine dopamine. It is formed from dopamine by the sulfotransferase (SULT) isoform SULT1A3. Dopamine 4-O-sulfate is found at lower levels in the brain and circulation than dopamine 3-O-sulfate.

HY-W014728

N-Methyldopamine hydrochloride 1 Publications Verification	Dopamine Receptor	Cardiovascular Disease Neurological Disease
N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor. N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research .

HY-128121

MLS1547	Dopamine Receptor	Neurological Disease
MLS1547 is a highly efficacious *G protein-biased dopamine* D2 receptor (D2R) agonist (K_i=1.2 μM). MLS1547 stimulates D2R G protein-mediated signaling (EC₅₀*=0.37 μM in a calcium mobilization assay). MLS1547 acts as an antagonist for dopamine* (DA)-stimulated β-arrestin recruitment to the D2R (IC₅₀=9.9 μM) .

HY-16736A

Centanafadine hydrochloride EB-1020 hydrochloride	Adrenergic Receptor Dopamine Transporter Serotonin Transporter	Neurological Disease Endocrinology
Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC₅₀s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.

HY-121685A

Tipepidine hydrochloride 1 Publications Verification	Potassium Channel	Neurological Disease
Tipepidine hydrochloride reversibly inhibits dopamine (DA) D₂ receptor-mediated GIRK currents (I_DA(GIRK)) with an IC₅₀ of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron . Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect .

HY-123538

GRK2 Inhibitor 1	Dopamine Receptor G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
GRK2 Inhibitor 1 (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a dual GRK2/β-ARK1 inhibitor that induces **dopamine (DA) inhibition reversal (DIR). GRK2 Inhibitor 1 can also block serotonin-induced or neurotensin-induced DIR reversal. Note: DIR** refers to the phenomenon in which neurons in addiction-related brain pathways become less sensitive to DA inhibition when exposed to moderate concentrations of DA for a long time .

HY-W206168

Tetrahydropapaveroline hydrobromide Norlaudanosoline hydrobromide	Dopamine Receptor	Neurological Disease
Tetrahydropapaveroline (Norlaudanosoline) hydrobromide, an isoquinoline alkaloid, is a condensation product of dopamine and dopaldehyde. Tetrahydropapaveroline hydrobromide inhibits [ ³H]DA uptake with a K_i of 41 μM. Tetrahydropapaveroline hydrobromide can be used for the study of Parkinson's disease and/or alcohol addiction .

HY-N2003

D-Tetrahydropalmatine 1 Publications Verification	Dopamine Receptor	Metabolic Disease
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis . D-Tetrahydropalmatine is a **dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1)** inhibitor .

HY-W010265

Butyrophenone 1-Phenylbutan-1-one; 1-Phenyl-1-butanone	Environmental Pollutants Dopamine Receptor	Neurological Disease
Butyrophenone (1-Phenylbutan-1-one) is a dopamine receptor (DA Receptor) antagonist and can be used in research on mental disorders .

HY-148867

UCM-1306	Dopamine Receptor	Neurological Disease
UCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD) .

HY-121650A

ADTN hydrobromide	Dopamine Receptor	Neurological Disease
ADTN hydrobromide is a long-acting *dopamine* agonist. ADTN hydrobromide significantly decreases the behavioral visual threshold of DA-IPC-depleted zebrafish .

HY-123837

MLS1082	Dopamine Receptor	Neurological Disease
MLS1082 is a pyrimidone-based *D1-like dopamine* receptor positive allosteric modulator, with an EC₅₀** of 123 nM for DA-stimulated G protein signaling .

HY-113316A

(±)-Salsolinol hydrochloride	Endogenous Metabolite Opioid Receptor	Neurological Disease
(±)-Salsolinol hydrochloride is the hydrochloride form of (±)-Salsolinol (HY-113316). (±)-Salsolinol hydrochloride is a Dopamine (HY-B0451)-derived endogenous metabolite. (±)-Salsolinol hydrochloride activates μ-opioid receptors (MORs), reduces GABAergic transmission, increases the excitability of *dopamine* (DA) neurons, and thus accelerates the sustained firing of neurons in the posterior ventral tegmental area (pVTA) .

HY-W152604

Cyclo(glycyl-L-leucyl) Cyclo(leu-gly)	Dopamine Receptor	Neurological Disease
Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias .

HY-156331

VU6004909	mGluR	Neurological Disease
VU6004909 is a blood-brain barrier penetrated mGlu1 positive allosteric modulator (PAM), with the EC₅₀s of 25.7 nM and 31 nM for human mGlu1 and rat mGlu1, respectively. VU6004909 reduces dorsolateral striatal dopamine (DA) release in vivo and displays antipsychotic efficacy .

HY-107370

Atomoxetine 4 Publications Verification Tomoxetine; (R)-Tomoxetine	Serotonin Transporter Sodium Channel	Neurological Disease Cancer
Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .

HY-106865

Mivazerol	Dopamine Receptor Adrenergic Receptor	Cardiovascular Disease
Mivazerol is a selective α2-adrenoceptor agonist. Mivazerol decreases the spontaneous release of serotonin (5-HT) and significantly inhibits the immobilization stress-induced enhancement of norepinephrine (NE), dopamine (DA) and dihydroxyphenylacetic acid (DOPAC). Mivazerol inhibits intrathecal release of glutamate evoked by halothane withdrawal in rats, and exerts neuroprotective effects in forebrain ischemia rats. Mivazerol can be used for myocardial ischemia research _.

HY-B1423

Lobeline α-Lobeline; L-Lobeline	nAChR Dopamine Transporter	Neurological Disease
Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation .

HY-16736

Centanafadine EB-1020	Adrenergic Receptor Dopamine Transporter Serotonin Transporter	Neurological Disease Endocrinology
Centanafadine is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC₅₀s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.

HY-D2871

DAyne	Biochemical Assay Reagents	Neurological Disease
DAyne is a Dopamine (DA)-mimetic probe. DAyne covalently binds to proteins modified by dopamine oxidation products (e.g., dopaquinone, DQ) to form adducts. DAyne is promising for research of Parkinson’s disease (PD), particularly neurotoxicity, protein modification, and related pathways (e.g., endoplasmic reticulum stress, cytoskeletal instability) caused by dopamine dysregulation .

HY-152170

bPiDI 1 Publications Verification	nAChR	Neurological Disease
bPiDI is a novel selective α6β2 nicotinic receptor antagonist. bPiDI inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs .

HY-W614656

Pterostilbene glucoside	Drug Derivative	Neurological Disease
Pterostilbene glucoside, a stilbene derivative of Resveratrol (HY-16561), is a bioactive compound with potent protective effects against oxidative stress. Pterostilbene glucoside effectively protects M1 muscarinic receptor-transfected COS-7 cells from dopamine (DA)-induced deficits in calcium clearance. Pterostilbene glucoside can be used for the study of the reduction of age-related neuronal and behavioral deleterious effects .

HY-W417914

4-Methylamphetamine hydrochloride 4-MA hydrochloride	5-HT Receptor Monoamine Transporter Dopamine Receptor	Neurological Disease
4-Methylamphetamine hydrochloride is a 5-HT1A receptor agonist that induces hypothermia in rats by binding to the 5-HT1A receptor. Additionally, 4-Methylamphetamine hydrochloride acts on norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters to increase the extracellular levels of these neurotransmitters. 4-Methylamphetamine hydrochloride can be used in the study of neurological disorders .

HY-145454

(R)-Preclamol (+)-3-PPP	Dopamine Receptor	Neurological Disease
(R)-Preclamol is a dopamine (DA) agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. (R)-Preclamol inhibits the locomotor activity of mice and rats in low doses .

HY-P3294

Onzigolide BIM-23A760; TBR-760	Dopamine Receptor Somatostatin Receptor	Neurological Disease Cancer
Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors .

HY-101377A

R(+)-8-OH-DPAT hydrobromide (R)-8-Hydroxy-2-dipropylaminotetralin hydrobromide	5-HT Receptor	Neurological Disease
R(+)-8-OH-DPAT ((R)-8-Hydroxy-2-dipropylaminotetralin) hydrobromide is a potent 5-HT_1A agonist. R(+)-8-OH-DPAT potentiates SUL (HY-B1059)-induced dopamine (DA) release in the medial prefrontal cortex (mPFC) .

HY-14472R

Tesofensine (Standard) NS-2330 (Standard)	Dopamine Transporter Serotonin Transporter Reference Standards	Metabolic Disease
Tesofensine (Standard) is the analytical standard of Tesofensine. This product is intended for research and analytical applications. Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC50=6.5 nM), norepinephrine (NE;IC50=1.7 nM), and serotonin (5-HT;IC50=11 nM), and with potentials as an anti-obesity agent . Tesofensine is a CNS acting anti-obesity agent .

HY-128420

Lobeline sulfate α-Lobeline sulfate; L-Lobeline sulfate	nAChR Dopamine Transporter	Neurological Disease
Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation .

HY-B0979R

Lobeline hydrochloride (Standard) α-Lobeline hydrochloride (Standard); L-Lobeline hydrochloride (Standard)	Reference Standards nAChR Dopamine Transporter	Neurological Disease
Lobeline (hydrochloride) (Standard) is the analytical standard of Lobeline (hydrochloride). This product is intended for research and analytical applications. Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation .

HY-121685

Tipepidine	Potassium Channel	Neurological Disease
Tipepidine reversibly inhibits dopamine (DA) D₂ receptor-mediated GIRK currents (I_DA(GIRK)) with an IC₅₀ of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron . Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect .

HY-103147

Mesulergine hydrochloride CU32-085 hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Mesulergine (CU32-085) hydrochloride is a potent 5-HT2C antagonist and **dopamine (DA)** agonist. Mesulergine hydrochloride presentes hyperphagia. Mesulergine hydrochloride has the potential for the research of cognitive processes .

HY-107674

bPiDDB	nAChR	Neurological Disease
bPiDDB is a potent nAChR antagonist. bPiDDB potently (IC₅₀=2 nM) inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs .

HY-W284026

PIM-35	Drug Derivative 5-HT Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
PIM-35 is a derivative of Indole (HY-W001132). PIM-35 significantly inhibits serotonin (5HT) and **dopamine (DA) uptake with a weak inhibitory effect on noradrenaline (NA)** uptake.PIM-35 has antidepressant activity and can be used for depression research .

HY-B0602S2

Desvenlafaxine-d6	Isotope-Labeled Compounds Serotonin Transporter	Neurological Disease
Desvenlafaxine-d₆ is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC₅₀ values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

HY-107370A

(Rac)-Atomoxetine hydrochloride (Rac)-Tomoxetine hydrochloride; (Rac)-LY 139603	Serotonin Transporter Sodium Channel	Metabolic Disease Cancer
(Rac)-Atomoxetine hydrochloride ((Rac)-Tomoxetine (hydrochloride); (Rac)-LY 139603) is the racemic mixture of Atomoxetine hydrochloride (HY-17385). Atomoxetine hydrochloride is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine hydrochloride is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .

HY-160440A

VU6021625	mAChR	Neurological Disease
VU6021625 is a selective antagonist muscarinic acetylcholine receptors (mAChRs), with the IC₅₀ value of 0.44 nM, 57 nM for human M4 and rat M4, respectively .

HY-118461

PD 120697	Dopamine Receptor	Neurological Disease
PD 120697 is an orally active **dopamine (DA)** agonist. PD 120697 inhibits striatal DA synthesis, DA neuronal firing, spontaneous locomotor activity, and reverses Reserpine (HY-N0480)-induced depression .

HY-118706

PD 118440	Dopamine Receptor	Neurological Disease
PD 118440 is an orally active dopamine (DA) agonist. PD 118440 has significant central nervous system effects, including inhibition of striatal DA synthesis, suppression of DA neuron firing, and reversal of Reserpine (HY-N0480)-induced depression in rats .

HY-167092

SD-1077	Isotope-Labeled Compounds	Neurological Disease
SD-1077 is a selectively deuterated precursor of dopamine (DA). SD-1077 can be used for the study of Parkinson's disease .

Cat. No.	Product Name

HY-L165

Dopamine Receptor Compound Library

267 compounds

Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life.

MCE designs a unique collection of 267 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

Cat. No.	Product Name	Type

HY-121650A

ADTN hydrobromide	Biochemical Assay Reagents
ADTN hydrobromide is a long-acting *dopamine* agonist. ADTN hydrobromide significantly decreases the behavioral visual threshold of DA-IPC-depleted zebrafish .

HY-182834

4-Arm-PEG2000-Dopamine	Biochemical Assay Reagents
4-Arm-PEG2000-Dopamine is a four-armed PEG derivative. Its core structure consists of four PEG chains, each terminal of which is modified with dopamine (DA) molecules. 4-Arm-PEG2000-Dopamine is used for surface modification, functional hydrogel preparation, and composite material construction.

HY-182834A

4-Arm-PEG5000-Dopamine	Biochemical Assay Reagents
4-Arm-PEG5000-Dopamine is a four-armed PEG derivative. Its core structure consists of four PEG chains, each terminal of which is modified with dopamine (DA) molecules. 4-Arm-PEG5000-Dopamine is used for surface modification, functional hydrogel preparation, and composite material construction.

HY-182834B

4-Arm-PEG10000-Dopamine	Biochemical Assay Reagents
4-Arm-PEG10000-Dopamine is a four-armed PEG derivative. Its core structure consists of four PEG chains, each terminal of which is modified with dopamine (DA) molecules. 4-Arm-PEG10000-Dopamine is used for surface modification, functional hydrogel preparation, and composite material construction.

HY-182834C

4-Arm-PEG20000-Dopamine	Biochemical Assay Reagents
4-Arm-PEG20000-Dopamine is a four-armed PEG derivative. Its core structure consists of four PEG chains, each terminal of which is modified with dopamine (DA) molecules. 4-Arm-PEG20000-Dopamine is used for surface modification, functional hydrogel preparation, and composite material construction.

Cat. No.	Product Name	Target	Research Area

HY-W152604

Cyclo(glycyl-L-leucyl) Cyclo(leu-gly)	Dopamine Receptor	Neurological Disease
Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias .

HY-P3294

Onzigolide BIM-23A760; TBR-760	Dopamine Receptor Somatostatin Receptor	Neurological Disease Cancer
Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors .

HY-P10435

KEMPFPKYPVEP	Dopamine Receptor	Neurological Disease
KEMPFPKYPVEP is a 12-amino acids neuropeptide, which upregulates levels of dopamine (DA) and norepinephrine (NE) in the prefrontal cortex, exhibits spatial and object recognition memory promoting ability in Scopolamine (HY-N0296)-induced amnesia mouse model .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0979

Lobeline hydrochloride 1 Publications Verification α-Lobeline hydrochloride; L-Lobeline hydrochloride	Alkaloids Campanulaceae Pyridine Alkaloids Plants Lobelia chinensis Lour. Source Classification	nAChR Dopamine Transporter
Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation .

HY-N2003

D-Tetrahydropalmatine 1 Publications Verification	Alkaloids Corydalis yanhusuo W. T. Wang Classification of Application Fields Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Dopamine Receptor
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis . D-Tetrahydropalmatine is a **dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1)** inhibitor .

HY-W010265

Butyrophenone 1-Phenylbutan-1-one; 1-Phenyl-1-butanone	Structural Classification Natural Products Piperaceae Plants Piper nigrum Linn. Source Classification	Environmental Pollutants Dopamine Receptor
Butyrophenone (1-Phenylbutan-1-one) is a dopamine receptor (DA Receptor) antagonist and can be used in research on mental disorders .

HY-B1423

Lobeline α-Lobeline; L-Lobeline	Alkaloids Other Alkaloids Campanulaceae Plants Lobelia chinensis Lour. Source Classification	nAChR Dopamine Transporter
Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation .

HY-128420

Lobeline sulfate α-Lobeline sulfate; L-Lobeline sulfate	Alkaloids other families Pyridine Alkaloids Plants Endogenous metabolite Source Classification	nAChR Dopamine Transporter
Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation .

HY-B0979R

Lobeline hydrochloride (Standard) α-Lobeline hydrochloride (Standard); L-Lobeline hydrochloride (Standard)	Alkaloids Structural Classification Campanulaceae Pyridine Alkaloids Plants Lobelia chinensis Lour. Source Classification	Reference Standards nAChR Dopamine Transporter
Lobeline (hydrochloride) (Standard) is the analytical standard of Lobeline (hydrochloride). This product is intended for research and analytical applications. Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation .

HY-N2426R

Clerodendrin (Standard)	Clerodendrum trichotomum Thunb. Flavonoids Verbenaceae Plants Isoflavones	Reference Standards Interleukin Related
Desvenlafaxine (Standard) is the analytical standard of Desvenlafaxine. This product is intended for research and analytical applications. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

Cat. No.	Product Name	Chemical Structure

HY-B0602S2

Desvenlafaxine-d6

Desvenlafaxine-d₆ is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC₅₀ values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

HY-167092

SD-1077
SD-1077 is a selectively deuterated precursor of dopamine (DA). SD-1077 can be used for the study of Parkinson's disease .

HY-B1110S

Nomifensine-d3 maleate

Nomifensine-d₃ ((±)-Nomifensine-d₃) maleate is the deuterium labeled Nomifensine maleate (HY-B1110A). Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

HY-B0602S3

Desvenlafaxine-d10

Desvenlafaxine-d₁₀ is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC₅₀ values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

HY-107370S

Atomoxetine-d7

Atomoxetine-d₇ (Tomoxetine-d₇) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .

HY-107370S1

Atomoxetine-d5

Atomoxetine-d₅ (Tomoxetine-d₅) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .

HY-17385S1

Atomoxetine-d7 hydrochloride

Atomoxetine-d₇ hydrochloride (Tomoxetine-d₇ hydrochloride) is the deuterium labeled Atomoxetine hydrochloride (HY-17385). Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with K_i values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .

Host:	Rat (1) Rabbit (2)
Reactivity:	Human (1) Rat (3) Mouse (3)
Application:	IHC-P (3) ICC/IF (1) WB (3) IHC-F (3) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (3)
Clonality:	Polyclonal (1) Monoclonal (2) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86855

	Dopamine Transporter Antibody (YA6548) DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; dopamine transporter 1 antibody; dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent dopamine transporter antibody; DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; dopamine transporter 1 antibody; dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent dopamine transporter antibody; Sodium-dependent dopamine transporter antibody; Solute carrier family 6 (neurotransmitter transporter dopamine), member 3 antibody; Solute carrier family 6 (neurotransmitter transporter), member 3 antibody; Solute carrier family 6 member 3 antibody; Variable number tandem repeat (VNTR) antibody;	IHC-F, IHC-P, WB	Mouse, Rat
	Dopamine Transporter Antibody (YA6548) is a Rat -derived and non-conjugated monoclonal antibody, targeting to Dopamine Transporter.

HY-P86856

	Dopamine Transporter Antibody (YA6549) DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; dopamine transporter 1 antibody; dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent dopamine transporter antibody; DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; dopamine transporter 1 antibody; dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent dopamine transporter antibody; Sodium-dependent dopamine transporter antibody; Solute carrier family 6 (neurotransmitter transporter dopamine), member 3 antibody; Solute carrier family 6 (neurotransmitter transporter), member 3 antibody; Solute carrier family 6 member 3 antibody; Variable number tandem repeat (VNTR) antibody;	WB, IHC-F, IHC-P	Mouse, Rat
	Dopamine Transporter Antibody (YA6549) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dopamine Transporter.

HY-P81165

	Dopamine Transporter Antibody DA transporter; DAT 1; DAT; DAT1; SC6A3_HUMAN; SLC6A3; Sodium dependent dopamine transporter; Sodium-dependent dopamine transporter; Solute carrier family 6 (neurotransmitter transporter dopamine), member 3; Solute carrier family 6 member 3; Variable number tandem repeat (VNTR); dopamine transporter; ADAT 1; Adenosine deaminase tRNA specific 1; HADAT1; tRNA specific adenosine deaminase 1.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	Dopamine Transporter Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Dopamine Transporter.

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